• 成都軍區(qū)總醫(yī)院全軍普外中心實(shí)驗(yàn)室(成都610083);

為了探討增加細(xì)胞內(nèi)糖原含量能否改善肝臟缺血再灌注損傷程度，本實(shí)驗(yàn)對(duì)3組糖原含量顯著不同的兔肝臟缺血再灌注過程中的組織形態(tài)學(xué)、肝臟酶學(xué)、組織ATP含量、細(xì)胞膜Ca2+-ATP酶活性及胞漿內(nèi)游離Ca2+濃度進(jìn)行了觀察。結(jié)果： 糖原含量高的肝臟，其細(xì)胞能量代謝旺盛，細(xì)胞膜Ca2+-ATP酶活性強(qiáng)，胞漿內(nèi)游離Ca2+濃度相對(duì)穩(wěn)定，組織結(jié)構(gòu)及功能損傷輕。本實(shí)驗(yàn)結(jié)果提示： 缺血前增加肝臟糖原含量可顯著地拮抗肝臟缺血再灌注損傷。

引用本文： 湯禮軍,田伏洲,王雨,李曉軍,尹致良. 肝細(xì)胞糖原拮抗肝臟缺血再灌注損傷及其相關(guān)機(jī)理的研究. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(4): 196-198. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1. Cywes R, Greig PD, Morgan GR, et al. Rapid donor liver nutritional enhancement in a large animal model. Hepatology, 1992; 16(5)∶1271.
2. Astarcioglu I, Adam R, Gigou M, et al. High levels of glycogen in the donor liver improve survival after liver transplantation in rats. Transplant Proc, 1991; 23(5)∶2465.
3. Wolf RFE, Hoeven JAB, Kamman RL, et al. Tissue pH in cold stored human donor livers preserved in university of wisconsin solution. Transplantation, 1996; 61(1)∶66.
4. Cywes R, Paul CB, Juan R, et al. Effect of intrapartal glucose on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg, 1992; 216(3)∶235.
5. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 1985; 260(9)∶3440.
6. 湯禮軍， 田伏洲. 肝臟缺血再灌注損傷介質(zhì)的研究現(xiàn)況. 肝膽外科雜志， 1998； 6(5)∶318.
  1. 1. Cywes R, Greig PD, Morgan GR, et al. Rapid donor liver nutritional enhancement in a large animal model. Hepatology, 1992; 16(5)∶1271.
  2. 2. Astarcioglu I, Adam R, Gigou M, et al. High levels of glycogen in the donor liver improve survival after liver transplantation in rats. Transplant Proc, 1991; 23(5)∶2465.
  3. 3. Wolf RFE, Hoeven JAB, Kamman RL, et al. Tissue pH in cold stored human donor livers preserved in university of wisconsin solution. Transplantation, 1996; 61(1)∶66.
  4. 4. Cywes R, Paul CB, Juan R, et al. Effect of intrapartal glucose on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg, 1992; 216(3)∶235.
  5. 5. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 1985; 260(9)∶3440.
  6. 6. 湯禮軍， 田伏洲. 肝臟缺血再灌注損傷介質(zhì)的研究現(xiàn)況. 肝膽外科雜志， 1998； 6(5)∶318.