為探討p21ras和nm23H1表達(dá)與胃癌淋巴結(jié)轉(zhuǎn)移的關(guān)系,采用LSAB法觀察了80例胃癌患者的p21ras和nm23H1的表達(dá),并分析其與淋巴結(jié)轉(zhuǎn)移的關(guān)系。結(jié)果:有淋巴結(jié)轉(zhuǎn)移(LNM)組p21ras表達(dá)陽(yáng)性率(62.5%)明顯高于無(wú)LNM組(42.5%),但nm23H1表達(dá)陽(yáng)性率(27.5%)則明顯低于無(wú)LNM組(47.5%);LNM數(shù)為1～3枚的p21ras表達(dá)陽(yáng)性率(33.3%)明顯低于4～7枚和 gt;8枚的LNM組(45.8%和71.4%);N1組的表達(dá)陽(yáng)性率(36.4%)明顯低于N2和N3組(52.2%和83.3%)。LNM為1～3枚的nm23H1表達(dá)陽(yáng)性率(44.4%)明顯高于4～7枚和 gt;8枚的LNM組(25.0%和0%),LNM為4～7枚組的nm23H1表達(dá)陽(yáng)性率明顯高于 gt;8枚組;N1組nm23H1表達(dá)陽(yáng)性率(45.5%)明顯高于N2和N3組(21.7%和0%)。上述結(jié)果提示,胃癌p21ras和nm23H1的表達(dá)與淋巴結(jié)轉(zhuǎn)移密切相關(guān),可作為胃癌患者預(yù)測(cè)轉(zhuǎn)移和預(yù)后的指標(biāo)。
引用本文： 秦環(huán)龍,毛明華,張惠箴. p21ras和nm23H1表達(dá)與胃癌淋巴結(jié)轉(zhuǎn)移的關(guān)系. 中國(guó)普外基礎(chǔ)與臨床雜志, 1999, 6(4): 221-223. doi: 復(fù)制
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