• 第三軍醫(yī)大學(xué)西南醫(yī)院普通外科(重慶400038);

為觀察Tenascin(TN)在乳腺不典型增生癌變過程中的表達(dá)變化，采用SP免疫組化染色法檢測(cè)了50例不同乳腺組織中TN的表達(dá)情況。結(jié)果顯示： 正常及Ⅰ級(jí)增生的乳腺組織中無TN表達(dá)，2例Ⅱ級(jí)不典型增生的乳腺組織中有TN表達(dá)，Ⅲ級(jí)不典型增生及浸潤(rùn)性導(dǎo)管癌中TN表達(dá)陽(yáng)性率分別為80%和90%，與Ⅱ級(jí)不典型增生相比明顯增高(Ｐ＜0.01)。部分癌細(xì)胞胞漿中也有TN表達(dá)。本實(shí)驗(yàn)結(jié)果提示，重度不典型增生的乳腺組織間質(zhì)中TN的表達(dá)可能起限制不典型增生細(xì)胞向外生長(zhǎng)的作用。

引用本文： 韓曉蓉,姜軍,馬宏敏. 乳腺不典型增生及乳腺癌中Tenascin的表達(dá). 中國(guó)普外基礎(chǔ)與臨床雜志, 1999, 6(5): 261-262. doi: 復(fù)制

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7. Jahkola T, Toivonen T, Von Smitten K, et al. Expression of tenascin in invasion border of early breast cancer correlates with higher risk of destant metastasis. Int J Cancer, 1996; 69(6)∶445.
8. Yoshida T, Ishihara A, Hirokawa Y, et al. Tenascin in breast cancer development is epithelial tenascin a marker for poor prognosis? Cancer Lett, 1995; 90(1)∶65.
9. Kalembey I, Yoshida T, Iriyama KT, et al. Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. Int J Dev Biol, 1997; 41(4)∶569.
10. Meiners S, Marone M, Rittenhouse JL, et al. Regulation of astrocytic tenascin by basic fibroblast growth factor. Devl Biol, 1993; 160(2)∶480.
11. Chiquet ER, Hagios S. The complexity in regulating the expression of tenascin. Bioessays, 1995; 17(10)∶873.
12. GonzalezSancho JM, Alvarez DM, Caelles C, et al. Inhibition of tenascinC expression in mammary epithelial cells by thyroid hormone. Mol Carcinog, 1999; 24(2)∶99.
  1. 1. ChiquetEhrismann R. Tenascins, a growing family of extracellular matrix proteins. Experientia, 1995; 51(910)∶853.
  2. 2. Page DL. Cancer risk assessment in benign breast biopsies. Human Pathol, 1986; 17(9)∶871.
  3. 3. Erickson HP. TenascinC， tenascinR, tenascinX—a family of talented proteins in search of function. Curr Opin Cell Biol, 1993; 5(5)∶869.
  4. 4. Chiquet ER, Makie EJ, Pearson CA, et al. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell, 1986; 47(1)∶131.
  5. 5. Iskaros BF, X Hu, Sparano JA, et al. Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma. J Surg Oncol, 1998; 68(2)∶107.
  6. 6. Sakakura T, Kusakabe M. Can tenascin be rebundant in cancer development? Perspect Dev Neurobiol, 1994; 2(1)∶111.
  7. 7. Jahkola T, Toivonen T, Von Smitten K, et al. Expression of tenascin in invasion border of early breast cancer correlates with higher risk of destant metastasis. Int J Cancer, 1996; 69(6)∶445.
  8. 8. Yoshida T, Ishihara A, Hirokawa Y, et al. Tenascin in breast cancer development is epithelial tenascin a marker for poor prognosis? Cancer Lett, 1995; 90(1)∶65.
  9. 9. Kalembey I, Yoshida T, Iriyama KT, et al. Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. Int J Dev Biol, 1997; 41(4)∶569.
  10. 10. Meiners S, Marone M, Rittenhouse JL, et al. Regulation of astrocytic tenascin by basic fibroblast growth factor. Devl Biol, 1993; 160(2)∶480.
  11. 11. Chiquet ER, Hagios S. The complexity in regulating the expression of tenascin. Bioessays, 1995; 17(10)∶873.
  12. 12. GonzalezSancho JM, Alvarez DM, Caelles C, et al. Inhibition of tenascinC expression in mammary epithelial cells by thyroid hormone. Mol Carcinog, 1999; 24(2)∶99.