為觀察乳腺良惡性疾病中微血管密度(microvessel density,MVD)的分布以及MVD與乳腺癌腫瘤大小(T)、組織學(xué)分級、雌激素受體水平(ER)及腋淋巴結(jié)轉(zhuǎn)移的關(guān)系，用Ⅷ因子抗體作病理切片的免疫組織化學(xué)染色，在顯微鏡下進行微血管計數(shù)。結(jié)果： 乳腺癌的MVD均值為30.8±19.4個/200倍視野，明顯大于乳腺良性腫瘤的MVD均值(16.09±7.9個/200倍視野)，Ｐ＜0.01； 乳腺癌中，MVD與腫瘤大小、組織學(xué)分級及腋淋巴轉(zhuǎn)移有關(guān)(Ｐ＜0.05)，而與雌激素受體水平無關(guān)。本實驗結(jié)果提示： 乳腺癌的MVD大于良性乳腺疾病者，可作為判斷乳腺癌患者預(yù)后的指標(biāo)之一。
引用本文： 李宏江,敬靜,朱精強,趙揚冰,張世羽,史宗道. 乳腺疾病中微血管的觀察分析. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(5): 285-287. doi: 復(fù)制
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| 3. | Folkman J. Introduction: angiogenesis and cancer. Semin Cancer Biol, 1992; 84(3)∶47. |
| 4. | Gimbrone MA Jr, Gullino PM. Neovascularization induced by introcular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues. J Natl Cancer Inst, 1976; 56(2)∶305. |
| 5. | Guinerbretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst, 1994; 86(8)∶635. |
| 6. | Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science, 1977; 195(38)∶880. |
| 7. | Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet, 1992; 340(8828)∶1120. |
| 8. | Da Silva ID, De Lima GR, Gebrim LH, et al. Invasive ductal carcinoma, fibroadenoma and adjacent breast stroma angiogenesis: an immunohistochemical and morphometrical study. Bull Assoc Anat Nancy, 1996; 80(250)∶17. |
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- 1. 李宏江， 朱精強. 乳癌中微血管活性檢測的意義. 國外醫(yī)學(xué)·外科學(xué)分冊， 1998； (6)∶344.
- 2. Algire GH, Chalkley HW, Legallais FY, et al. Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions in mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst, 1945; 25(6)∶73.
- 3. Folkman J. Introduction: angiogenesis and cancer. Semin Cancer Biol, 1992; 84(3)∶47.
- 4. Gimbrone MA Jr, Gullino PM. Neovascularization induced by introcular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues. J Natl Cancer Inst, 1976; 56(2)∶305.
- 5. Guinerbretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst, 1994; 86(8)∶635.
- 6. Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science, 1977; 195(38)∶880.
- 7. Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet, 1992; 340(8828)∶1120.
- 8. Da Silva ID, De Lima GR, Gebrim LH, et al. Invasive ductal carcinoma, fibroadenoma and adjacent breast stroma angiogenesis: an immunohistochemical and morphometrical study. Bull Assoc Anat Nancy, 1996; 80(250)∶17.
- 9. 賈蘭玲， 李振， 胡萍等. 血型抗原單克隆抗體對乳腺癌新生血管的檢測及意義. 中國醫(yī)科大學(xué)學(xué)報， 1995； 24(1)∶99.
- 10. Weidner N, Semple SP, Welch WR, et al. Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma. N Engl J Med, 1991; 324(1)∶1.
- 11. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg, 1966; 164(3)∶491.