通過在蛙皮縮膽囊素(caerulein,Cn)誘導的輕癥胰腺炎時用阿片類止瀉劑(lopemin)抑制腸運動和在脫氧膽酸胰管注射的重癥胰腺炎時用大黃促進腸運動的兩個系列鼠實驗為基礎，探討了腸道運動力學改變對急性胰腺炎的病程和預后的影響。結(jié)果顯示： 抑制運動將增加胰腺炎的繼發(fā)感染和內(nèi)毒素血癥，反之促進腸運動則減少細菌移位和內(nèi)毒素血癥，從而降低實驗大鼠的死亡率。提示： 腸動力學改變與急性胰腺炎的病程及預后有密切關系，通過促進腸道運動可減少急性胰腺炎的繼發(fā)感染和多器官衰竭，從而改善胰腺炎的預后。
引用本文： 陳曉理,馮凱祥. 腸道動力學改變在急性胰腺炎的病程及治療中的意義. 中國普外基礎與臨床雜志, 1999, 6(6): 325-327. doi: 復制
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