• 1. 浙江醫(yī)科大學(xué)附屬一院普外科(杭州310003)2. 浙江醫(yī)科大學(xué)微生物教研室;

為探討腸源性感染的發(fā)生機理，將60只SD大鼠隨機均分成腸梗阻組、環(huán)磷酰胺+腸梗阻組、環(huán)磷酰胺組和假手術(shù)組4組。回腸機械性腸梗阻24小時后取各組鼠腹腔液、門靜脈血、心臟血、腸系膜淋巴結(jié)(MLN)和回腸末段內(nèi)容物作細菌定量分析，同時測定門靜脈血內(nèi)毒素含量。結(jié)果顯示：腸梗阻24小時即導(dǎo)致門靜脈內(nèi)毒素血癥，腸內(nèi)G－桿菌大量繁殖，腸菌移位于MLN中。免疫抑制劑環(huán)磷酰胺不僅增加腸梗阻時腸菌移位的發(fā)生率(100%∶80%)，且使更多的腸菌存活于MLN中并向體循環(huán)內(nèi)播散。由此表明，在免疫抑制狀態(tài)下腸菌經(jīng)淋巴途徑侵入腸外組織，在腸源性感染的發(fā)生中起著重要作用。

引用本文： 沈巖,鄭樹森,顧克洲,孫義國,李正之. 免疫抑制對大鼠腸梗阻早期腸菌移位的影響. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(1): 9-11. doi: 復(fù)制

1. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg, 1990; 125(3)∶403.
2. Fry DE. Multiple system organ failure. Surg Clin North Am,1988; 68(1)∶107.
3. Carrico CJ,Meakings JL, Marshall JC, et al.Multiple organ failuer syndrome, the gastrointestinal tract： the “Motor” of MOF. Arch Surg, 1986; 121(2)∶196.
4. Marshall JC, Christou NV, Horn R,et al. The microbiology of multiple failure： the proximal gastrointestinal tract as an occult reservoir of pathogens. Arch Surg, 1988; 123(3)∶309.
5. Deitch EA, Winterton J, Li M,et al. The gut as a portal of entry for bacteria. Ann Surg, 1987; 205(6)∶681.
6. Berg RD, Garlington AW. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun,1979; 23(2)∶403.
7. Deitch EA, Winterton J, Berg R. Thermal injury promotes bacterial translocation from the gastrointestinal tract in mice with impared Tcellmediated immunity. Arch Surg, 1986; 121(1)∶97.
8. Backer JW, Deitch EA, Li M,et al.Hemorrhagic shock induces bacterial translocation from the gut. J Trauma, 1988; 28(7)∶896.
9. Navaratnam RL, Morris SE, Traber DL,et al.Endotoxin (LPS) increase mesenteric vascular resistance (MVR) and bacterial translocation (BT). J Trauma, 1990; 30(9)∶1104.
10. Kobayashi T, Ohmori T, Yanai M,et al.The analysis of the defense mechanism against indigenous bacterial translocation in xirradiated mice. Microbiol Immunol,1991; 35(4)∶315.
11. Ailverdy JC, Aoys E, Moss GS. Total parenteral nutrition promotes bacterial translocation from the gut. Surgery, 1988; 104(2)∶185.
12. Deitch EA, Berg RD. Bacterial translocation from the gut： a mechanism of infection. J Burn Care Rehabil, 1987; 8(6)∶475.
13. Well CL, Maddaus MA, Simmons RL. Role of the macrophage in the translocation of intestinal bacteria. J Trauma, 1987; 122(1)∶48.
14. Deitch EA, Bridge WM, Ma JW,et al.Obstructed intestine as a reservoir for systemic infection. Am J Surg, 1990; 159(4)∶394.
15. Mainous MR, Tso T, Berg RD, et al.Studies of the route, magnitude and time course of bacterial translocation in a model of systemic inflammation. Arch Surg, 1991; 126(1)∶33.
  1. 1. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg, 1990; 125(3)∶403.
  2. 2. Fry DE. Multiple system organ failure. Surg Clin North Am,1988; 68(1)∶107.
  3. 3. Carrico CJ,Meakings JL, Marshall JC, et al.Multiple organ failuer syndrome, the gastrointestinal tract： the “Motor” of MOF. Arch Surg, 1986; 121(2)∶196.
  4. 4. Marshall JC, Christou NV, Horn R,et al. The microbiology of multiple failure： the proximal gastrointestinal tract as an occult reservoir of pathogens. Arch Surg, 1988; 123(3)∶309.
  5. 5. Deitch EA, Winterton J, Li M,et al. The gut as a portal of entry for bacteria. Ann Surg, 1987; 205(6)∶681.
  6. 6. Berg RD, Garlington AW. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun,1979; 23(2)∶403.
  7. 7. Deitch EA, Winterton J, Berg R. Thermal injury promotes bacterial translocation from the gastrointestinal tract in mice with impared Tcellmediated immunity. Arch Surg, 1986; 121(1)∶97.
  8. 8. Backer JW, Deitch EA, Li M,et al.Hemorrhagic shock induces bacterial translocation from the gut. J Trauma, 1988; 28(7)∶896.
  9. 9. Navaratnam RL, Morris SE, Traber DL,et al.Endotoxin (LPS) increase mesenteric vascular resistance (MVR) and bacterial translocation (BT). J Trauma, 1990; 30(9)∶1104.
  10. 10. Kobayashi T, Ohmori T, Yanai M,et al.The analysis of the defense mechanism against indigenous bacterial translocation in xirradiated mice. Microbiol Immunol,1991; 35(4)∶315.
  11. 11. Ailverdy JC, Aoys E, Moss GS. Total parenteral nutrition promotes bacterial translocation from the gut. Surgery, 1988; 104(2)∶185.
  12. 12. Deitch EA, Berg RD. Bacterial translocation from the gut： a mechanism of infection. J Burn Care Rehabil, 1987; 8(6)∶475.
  13. 13. Well CL, Maddaus MA, Simmons RL. Role of the macrophage in the translocation of intestinal bacteria. J Trauma, 1987; 122(1)∶48.
  14. 14. Deitch EA, Bridge WM, Ma JW,et al.Obstructed intestine as a reservoir for systemic infection. Am J Surg, 1990; 159(4)∶394.
  15. 15. Mainous MR, Tso T, Berg RD, et al.Studies of the route, magnitude and time course of bacterial translocation in a model of systemic inflammation. Arch Surg, 1991; 126(1)∶33.