放免法測定43例行大腸癌根治術(shù)患者空腹血清、癌組織及癌旁粘膜中胃泌素水平。結(jié)果：大腸癌患者空腹血清胃泌素水平明顯高于正常血對照組(Ｐ＜0.05)；根治術(shù)后卻明顯降低(Ｐ＜0.05)，且與血對照組比無顯著性差異(Ｐ＞0.05)。高分化腺癌組血清胃泌素水平變化明顯；癌組織及癌旁粘膜中胃泌素水平均高于正常大腸粘膜(Ｐ＜0.05)。本結(jié)果提示：胃泌素對大腸癌的生長可能有調(diào)控作用，測定血清及癌組織中胃泌素水平有助于了解大腸癌的生物學(xué)特性及指導(dǎo)對大腸癌的激素治療。
引用本文： 李家琪,何雙梧,李益仁,張連陽. 大腸癌患者血清及癌組織中胃泌素水平測定的臨床意義. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(1): 16-18. doi: 復(fù)制
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- 1. Singh P, Walker JP, Townsend CM, et al.Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC26) in BALB/C mice. Cancer Res, 1986; 46∶1612.
- 2. Watson SA, Durrant LG, Croshic JD,et al. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer, 1989； 43∶692.
- 3. Smith JP, Wood JG, Soloman TE. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Digestive Dis Science, 1989; 34(2)∶171.
- 4. Wang K, Beardshall K, Waters CM,et al. Postprandial hypergastrinameic in patients with colorectal cancer. Gut, 1991; 32∶1352.
- 5. 蔡文琴，王伯云.實用免疫細(xì)胞化學(xué)室. 成都：四川科學(xué)技術(shù)出版社，1988∶214.
- 6. Nemeth J,Taylor B, Pauwels S, et al.Indentification of progastrin derived peptide in colorectal carcinoma extracts. Gut, 1993; 34(1)∶90.
- 7. Waston SA, Durrant LG, Wencyk PM, et al.Intracellular gastrin in human gastrointestinal tumor cells. National Cancer Institute, 1991; 83(12)∶866.
- 8. Hoosein NM, Diener PA, Curry RC, et al. Evidence for autocrin growth stimulation of cultured colon tumor cells by a gastrin cholecystokininlike peptide. Experimental Cell Research, 1990; 186∶15.
- 9. 張群星，曾民德，施堯等. 胃癌組織及癌旁粘膜的胰高血糖素、胰島素和胃泌素含量的測定. 中華消化雜志， 1991； 11(3)∶144.
- 10. Imdall A， Eggstein ST, Crance C,et al. Growth of colorectal carcinoma cell:regulation in vitro by gastrin, pentagastrin and the gastrinreceptor antagonist proglumid. J Cancer Res Clinocol, 1989; 115∶388.
- 11. Beauchamp RD, Townsand CM, Singh P,et al.Proglumid,a gastrin receptor antagonist, inhibit growth of colon cancer and enhances survival in mice. Ann Surg, 1985; 302(3)∶303.