用裸小鼠胃癌細(xì)胞移植瘤作為體內(nèi)誘導(dǎo)分化研究模型，采用移植瘤生長(zhǎng)狀態(tài)、移植瘤組織學(xué)、超微結(jié)構(gòu)、細(xì)胞周期動(dòng)力學(xué)變化及移植瘤p53、p21蛋白表達(dá)作為指標(biāo)，研究了不同劑量的全反式維甲酸(ATRA)對(duì)裸小鼠胃癌細(xì)胞移植瘤的抗增殖及誘導(dǎo)分化作用。結(jié)果發(fā)現(xiàn)：在ATRA 300～1 000μg/只·d的劑量下，對(duì)移植瘤具有明顯生長(zhǎng)抑制作用，并對(duì)移植瘤細(xì)胞有較強(qiáng)的誘導(dǎo)分化作用；同時(shí)可抑制移植瘤癌細(xì)胞p53、p21的表達(dá)。本實(shí)驗(yàn)結(jié)果提示：ATRA在體內(nèi)對(duì)人胃癌細(xì)胞有較強(qiáng)的抗增殖和誘導(dǎo)分化作用，這種抗癌作用可能與ATRA抑制癌細(xì)胞p53及p21表達(dá)，促進(jìn)癌細(xì)胞凋亡有密切關(guān)系。
引用本文： 黃承良,王代科,劉寶華. 全反式維甲酸對(duì)人胃癌裸小鼠移植瘤的抗增殖及誘導(dǎo)分化作用. 中國(guó)普外基礎(chǔ)與臨床雜志, 1998, 5(3): 129-131. doi: 復(fù)制
| 1. | Shibata MA, Krust A, Nisslon N, et al. Modification of BHA forestomach carcinogenesis in rats: inhibition by diethymaleste or indomethacin and enhance by retinoid. Carcinogenesis, 1993; 14(7)∶1265. |
| 2. | D.施梅爾著.惡性腫瘤的發(fā)生、生長(zhǎng)和化療.第1版.北京：科學(xué)技術(shù)出版社，1984∶445. |
| 3. | 張勝本，張連陽(yáng)主編.腫瘤化學(xué)治療敏感性與抗藥性.第1版.成都：四川科學(xué)技術(shù)出版社， 1995∶91. |
| 4. | Brooc JSJ. Analytic false positivity with immunohistochemistry. Am J Clin Pathol, 1984; 82(1)∶134. |
| 5. | 沈敏，許建明，童菊芳等.全反式維甲酸對(duì)胃癌細(xì)胞株SGC7901的抗增殖及誘導(dǎo)分化作用的研究.中國(guó)藥學(xué)雜志， 1991； 26(12)∶722. |
| 6. | Skashita A, Ress J, Kadin M, et al. 9cis retinoic acid: effects on normal and leukemia hepatopoiesis in vitro. Blood, 1996; 81(5)∶1009. |
| 7. | Gwyn T, Saurit G, Moria C, et al. Molecular regulation of apoptosis: genetic controls on cell death. Cell, 1993; 74(6)∶777. |
| 8. | Kerin JK, Green MH, Berg J, et al. Evidence for the involvement of RAR dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. J Bio Chem, 1995; 11(2)∶6022. |
- 1. Shibata MA, Krust A, Nisslon N, et al. Modification of BHA forestomach carcinogenesis in rats: inhibition by diethymaleste or indomethacin and enhance by retinoid. Carcinogenesis, 1993; 14(7)∶1265.
- 2. D.施梅爾著.惡性腫瘤的發(fā)生、生長(zhǎng)和化療.第1版.北京：科學(xué)技術(shù)出版社，1984∶445.
- 3. 張勝本，張連陽(yáng)主編.腫瘤化學(xué)治療敏感性與抗藥性.第1版.成都：四川科學(xué)技術(shù)出版社， 1995∶91.
- 4. Brooc JSJ. Analytic false positivity with immunohistochemistry. Am J Clin Pathol, 1984; 82(1)∶134.
- 5. 沈敏，許建明，童菊芳等.全反式維甲酸對(duì)胃癌細(xì)胞株SGC7901的抗增殖及誘導(dǎo)分化作用的研究.中國(guó)藥學(xué)雜志， 1991； 26(12)∶722.
- 6. Skashita A, Ress J, Kadin M, et al. 9cis retinoic acid: effects on normal and leukemia hepatopoiesis in vitro. Blood, 1996; 81(5)∶1009.
- 7. Gwyn T, Saurit G, Moria C, et al. Molecular regulation of apoptosis: genetic controls on cell death. Cell, 1993; 74(6)∶777.
- 8. Kerin JK, Green MH, Berg J, et al. Evidence for the involvement of RAR dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. J Bio Chem, 1995; 11(2)∶6022.