為探討門脈高壓性胃病的發(fā)病機(jī)理，將Wistar大鼠42只隨機(jī)分為肝硬變組(LC組，n＝15)、門靜脈狹窄組(PVS組，n＝15)和假手術(shù)組(SO組，n＝12)，以觀察其血流動力學(xué)指標(biāo)、胃壁結(jié)合粘液(GP)、胃粘膜內(nèi)源性前列腺素E2(PGE2)水平、胃基礎(chǔ)泌酸量(BAS)以及H＋返滲量(H＋BD)。結(jié)果：LC組及PVS組大鼠內(nèi)臟血流量較SO組明顯增加(Ｐ＜0.001)，但胃粘膜卻處于缺血狀態(tài)；其GP和PGE2含量也較SO組顯著下降(Ｐ＜0.01)，其中LC組又較PVS組更低(Ｐ＜0.05)；BAS 3組間無差異，但LC組及PVS組大鼠之H＋BD明顯高于SO組(Ｐ＜0.001)，且以LC組最為顯著。本實(shí)驗(yàn)結(jié)果提示：門靜脈高壓大鼠胃粘膜屏障功能遭到嚴(yán)重破壞，尤以肝硬變大鼠為甚；門脈高壓性胃病的發(fā)生與胃粘膜屏障功能削弱有關(guān)；肝功能受損參與胃粘膜病變的發(fā)生。
引用本文： 周東風(fēng),孫作祥,梁桂華,李紅梅,王占民. 門脈高壓大鼠胃粘膜屏障功能的實(shí)驗(yàn)研究. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(3): 135-137. doi: 復(fù)制
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- 2. Quinter E, Pique JM, Bombi JA, et al.Gastric mucosal ectasias causing bleeding in cirrhosis. Gastroenterology, 1987; 93(5)∶1054.
- 3. 吳孟超，楊廣順.大鼠肝硬變模型復(fù)制的研究. 中華實(shí)驗(yàn)外科雜志， 1984； 1(4)∶145.
- 4. Pique JM, Leung FM, Kitahora T, et al.Gastric mucosal blood flow and acid secretion in portal hypertensive rats. Gastroenterology, 1988; 95(3)∶727.
- 5. Sarfeh IJ, Tarnawski A, Malki, A, et al.Portal hypertension and gastric mucosal injury in rats. Gastroenterology, 1983; 84(5)∶987.
- 6. Agustin A, Luis A, Colombato, et al. Sequence of morphological and hemodynamic changes of gastric microvessels in portal hypertension. Gastroenterology, 1992; 102(6)∶2066.
- 7. Lundergren O. Gastric mucosal hemodynamics. Gastroenterol Cli Biol, 1985; 9(1)∶26.
- 8. Malagelada JR, Ahiguist DA, Moore Sc. Effect in prostaglandin synthesis and metablism in ulcer disease. Dig Dis Sci, 1986; 31(10)∶20S.
- 9. Viggiano TR, Gostout CJ. Portal hypertensive intestinal vasculopathy. Am J Gastroenterol, 1992; 87(8)∶944.