為了降低移植物免疫原性,誘導(dǎo)免疫耐受,本實驗采用單抗加補體方法消除大鼠甲狀旁腺移植物中的主要組織相容性Ⅰ類抗原(Ⅰa)陽性細胞,將其移植到同種受體腎包膜下,觀察移植物平均存活時間。結(jié)果顯示:處理組移植物平均存活時間為60天,對照組為14天,兩者相比有極顯著性差異(P<0.01)。說明消除Ⅰa抗原陽性細胞可顯著延長大鼠甲狀旁腺同種異體移植物存活時間。
引用本文: 張?zhí)?朱預(yù),王樹慧,張云,肖毅. 消除主要組織相容性Ⅰ類抗原陽性細胞延長大鼠甲狀旁腺同種異體移植物存活期. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(5): 263-264下轉(zhuǎn)269. doi: 復(fù)制
1. | Lafferty KJ, Prowse SJ, Simeonovic CJ. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol, 1983; 1(1)∶143. |
2. | 羅江明.甲狀旁腺同種異體移植.中華器官移植雜志,1987; 8(1)∶45. |
3. | Faustman D, Hauptfeld V, Lacy PE, et al. Prolongation of murine islet allograft by pretreatment of islets with antibody directed to Ⅰa determinants. Proc Natl Acad Sci USA, 1981; 78(6)∶5156. |
4. | 羅江明,朱預(yù).高氧培養(yǎng)甲狀旁腺對大鼠同種移植腺體存活時間的影響.中華器官移植雜志,1988; 9(2)∶73. |
- 1. Lafferty KJ, Prowse SJ, Simeonovic CJ. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol, 1983; 1(1)∶143.
- 2. 羅江明.甲狀旁腺同種異體移植.中華器官移植雜志,1987; 8(1)∶45.
- 3. Faustman D, Hauptfeld V, Lacy PE, et al. Prolongation of murine islet allograft by pretreatment of islets with antibody directed to Ⅰa determinants. Proc Natl Acad Sci USA, 1981; 78(6)∶5156.
- 4. 羅江明,朱預(yù).高氧培養(yǎng)甲狀旁腺對大鼠同種移植腺體存活時間的影響.中華器官移植雜志,1988; 9(2)∶73.