• 1. 西藏軍區(qū)總醫(yī)院外一科(拉薩850003)2. 四川省軍區(qū)干休所3. 成都軍區(qū)總醫(yī)院全軍普外中心;

為探討組織蛋白酶B在急性胰腺炎(AP)發(fā)病中的作用，對11只急性水腫性胰腺炎犬和12只急性出血壞死性胰腺炎犬(AHNP)的胰腺腺泡細胞內(nèi)組織蛋白酶B的分布情況進行了檢測，并與7只正常犬進行比較。結(jié)果：實驗犬AP早期即有胰腺腺泡細胞內(nèi)組織蛋白酶B的再分布現(xiàn)象，AHNP犬尤為明顯(Ｐ＜0.01)。由此表明，組織蛋白酶B在AP的發(fā)病中具有一定的作用。

引用本文： 王茂旭,劉厚東,曾嶸,李素芝,田伏洲. 組織蛋白酶B在急性胰腺炎發(fā)病中的作用探討. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(6): 338-339. doi: 復(fù)制

1. Mc Donald JK, Ellis. In the substrate specificity of cathepsin B1 and B2 including a new flurogonic substrate for cathepsin B1. Life Sci, 1975; 17∶1269.
2. Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (cmassive necrosis) with fat necrosis induced in mice by dlehionine fed with a cholinedeficient diet. Am J Pathol, 1975; 79∶465.
3. Bialek R, Willemer S, Arnold R, et al. Evidence of intracellular activation of serumproteases in acute ceruleininduced pancreatitis in rats. Scand J Gastroenterol, 1991; 26∶130.
4. Ohshio G, Saluja A, Steer ML. Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology, 1991; 199∶196.
5. Steer ML. Pathognesis of acute pancreatitis. Ann Rev Med, 1988; 39∶95.
6. Hirano T, Manake T, Yotsumoto F, et al. Effect of prostaglandin E on the restistribution of lysosomal enzyme in ceruleininduced pancreatitis. Hepatogastroenterology, 1993; 40∶155.
  1. 1. Mc Donald JK, Ellis. In the substrate specificity of cathepsin B1 and B2 including a new flurogonic substrate for cathepsin B1. Life Sci, 1975; 17∶1269.
  2. 2. Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (cmassive necrosis) with fat necrosis induced in mice by dlehionine fed with a cholinedeficient diet. Am J Pathol, 1975; 79∶465.
  3. 3. Bialek R, Willemer S, Arnold R, et al. Evidence of intracellular activation of serumproteases in acute ceruleininduced pancreatitis in rats. Scand J Gastroenterol, 1991; 26∶130.
  4. 4. Ohshio G, Saluja A, Steer ML. Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology, 1991; 199∶196.
  5. 5. Steer ML. Pathognesis of acute pancreatitis. Ann Rev Med, 1988; 39∶95.
  6. 6. Hirano T, Manake T, Yotsumoto F, et al. Effect of prostaglandin E on the restistribution of lysosomal enzyme in ceruleininduced pancreatitis. Hepatogastroenterology, 1993; 40∶155.