• 1. 蚌埠醫(yī)學(xué)院附屬醫(yī)院急診外科(蚌埠233000)2. 上海第二醫(yī)科大學(xué)瑞金醫(yī)院;

為探討急性胰腺炎患者血液中細(xì)胞因子變化與病情嚴(yán)重度及多器官功能障礙(MOD)之間的關(guān)系，對(duì)1994年至1996年入院的36例急性胰腺炎患者依據(jù)RANSON評(píng)分和CT評(píng)分將其分為輕型組(12例)和重型胰腺炎組(24例)，又將重型胰腺炎組中發(fā)生MODS的9例定名為障礙組。在入院第0、4、8天測(cè)定血清TNF、IL-6、CRP值。結(jié)果顯示胰腺炎早期患者血液中細(xì)胞因子在輕型組、重型組和障礙組之間依次升高，并有顯著性差異(Ｐ＜0.05)。由此表明急性胰腺炎細(xì)胞因子升高與疾病嚴(yán)重度和并發(fā)癥發(fā)生有關(guān)，極度升高者可能發(fā)生多器官衰竭，動(dòng)態(tài)檢測(cè)上述細(xì)胞因子有助于判斷患者的預(yù)后。

引用本文： 劉牧林,曹偉新,湯耀卿,尹浩然. 急性胰腺炎患者血液中細(xì)胞因子的變化. 中國(guó)普外基礎(chǔ)與臨床雜志, 1998, 5(6): 352-353下轉(zhuǎn)384. doi: 復(fù)制

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  1. 1. Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. British J Surg, 1996; 83(4)∶349.
  2. 2. Heath DI, Cruickshank A, Gudgeon M, et al. Role of interleukin 6 in mediating the acute phase protein response and potential as and early means of severity assessment in acute pancreatitis. Gut, 1993; 34∶41.
  3. 3. Deitch EA. Multiple organ failure. Ann Surg, 1992; 216(2)∶117.
  4. 4. Mckay CJ, Gallagher G, Brooks B, et al. Increased monocyte cytokine production in association with systemic complication in acute pancreatitis. Br J Surg, 1996; 83(7)∶919.
  5. 5. Pezzilli R, Billi P, Miniero R, et al. Serum interleukin6, interleukin8, and β2microglobulin in early assessment of severity of acute pancreatitis comparison with serum creactive protein. Dig Dis Sci, 1995; 40(11)∶2341.
  6. 6. Rinderknecht H. Genetic determinants of mortality in acute necrotizing pancreatitis. Int J Pancreatol, 1994; 16(1)∶11.