從加強(qiáng)醫(yī)療病房的危重患者中選取因呼吸衰竭而給予呼吸機(jī)支持的患者40例，隨機(jī)分為A組20例進(jìn)行腸外營(yíng)養(yǎng)(parenteral nutrition,PN)治療；B組20例未行PN治療。對(duì)通氣/換氣功能各指標(biāo)進(jìn)行分析，結(jié)果兩組患者的呼吸頻率、pH、PaO2、PaCO2及HCO3-無(wú)明顯差異；A組氧分壓與吸入氣氧濃度比值輕度降低，而肺泡-動(dòng)脈氧壓差及肺內(nèi)分流明顯升高。提示PN中的脂肪乳和高糖可能是導(dǎo)致呼吸功能改變的重要因素。
引用本文： 康焰,吳言濤,羅傳興,應(yīng)明英,王兵. 腸外營(yíng)養(yǎng)對(duì)呼吸功能不全患者的影響. 中國(guó)普外基礎(chǔ)與臨床雜志, 1997, 4(1): 27-29. doi: 復(fù)制
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- 1. Zakinthinos S,Baltopoulos G,Roussos C.Fat emusion and ARDS.Chest,1990;98(2):509.
- 2. Hwang TL,Huang SL,Chen MF.Effects of intravenous fat emulsion on respiratory failure.Chest,1990;97(4):934.
- 3. Green HL,Hazlett D,Demaree R.Relationship between intralipid-induced hyperlipemia and pulmonary function.Am J Clin Nutr,1976;29:127.
- 4. Sundstron G,Zauner CZ,Arborelius M.Decrease in pulmonary diffusing capacity during lipid infusion in healthy men.J Appl Physiol,1973;34:816.
- 5. Kuo PT,Whereat AF.Lipemia as a cause of arterial oxygen unsaturation,and the effect of its control in patients with atherosclerosis.Circulation,1957;16:493.
- 6. Venus B,Smith RA,Patel C,et al.Hemodynamic and gas exchange alterations during intralipid infusion in patients with adult respiratory distress syndrome.Chest,1989;95(6):1278.
- 7. Rubin M,Bilik R,Mor R,et al.Alteration of pulmonary function by filtration of intranenous nutrient mixture.Nutrition,1993;9(2):153.
- 8. Mathru M,Dries DJ,Zecca A,et al.Effect of fast vs slow intralipid infusion on gas exchange,pulmonary hemodynamics,and prostaglandin metabolism.Chest,1991;89(2):426.