對急性阻塞行黃疸兔模型的馬尿酸合成試驗(HAT)和反映肝臟能量代謝情況的能荷、線粒體氧化磷酸化率等進(jìn)行了研究。結(jié)果顯示：在急性阻塞性黃疸時，能荷（0.72±0.02）和線粒體氧化磷酸化率（38.3±2.4）分別與對照組（0.81±0.01和62.1±5.1）比較，均下降明顯（P lt;0.001）。HAT（32.7±17.6mg/h）與對照組（98.4±32.0mg/h）相比也明顯下降（P lt;0.001）；且HAT和能荷的相關(guān)系數(shù)為0.786。實驗結(jié)果提示：HAT可作為反映肝臟能量代謝的可靠指標(biāo)。
引用本文： 張峰 ,俞學(xué)明,王學(xué)浩,嚴(yán)律南,小澤和惠. 馬尿酸試驗作為急性阻塞性黃疸時肝臟能量代謝負(fù)荷指標(biāo)的實驗研究. 中國普外基礎(chǔ)與臨床雜志, 1997, 4(2): 63-67. doi: 復(fù)制
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- 4. Ozawa K,Yamaoka Y.Changes in hepatic energy charge blood ketone body ratio and indocyanine green clearance in relation to DNA synthesis after hepatectomy.Life Science,1982;11:647.
- 5. Gatley ST,Sherratt SA.The synthesis of hippurate from benzoate and glycine by rat liver mitochondria.Biochem J,1977;166(1):39.
- 6. Couger ML.Mechanism of bilirubin toxicity on tissue culture cell.Biochem Med,1971;5:1.