對(duì)急性阻塞行黃疸兔模型的馬尿酸合成試驗(yàn)(HAT)和反映肝臟能量代謝情況的能荷、線粒體氧化磷酸化率等進(jìn)行了研究。結(jié)果顯示：在急性阻塞性黃疸時(shí)，能荷（0.72±0.02）和線粒體氧化磷酸化率（38.3±2.4）分別與對(duì)照組（0.81±0.01和62.1±5.1）比較，均下降明顯（P lt;0.001）。HAT（32.7±17.6mg/h）與對(duì)照組（98.4±32.0mg/h）相比也明顯下降（P lt;0.001）；且HAT和能荷的相關(guān)系數(shù)為0.786。實(shí)驗(yàn)結(jié)果提示：HAT可作為反映肝臟能量代謝的可靠指標(biāo)。
引用本文： 張峰 ,俞學(xué)明,王學(xué)浩,嚴(yán)律南,小澤和惠. 馬尿酸試驗(yàn)作為急性阻塞性黃疸時(shí)肝臟能量代謝負(fù)荷指標(biāo)的實(shí)驗(yàn)研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 1997, 4(2): 63-67. doi: 復(fù)制
| 1. | Aogama H,Kamigama Y,Ukikusa M,et al.Clinical significance of hippurate-synthesizing capacity in surgical patients with liver disease:a metabolic tolerance test.J Lab Clin Med,1986;108(3):456. |
| 2. | Tanaka A,Feng Z,Inomoto T,et al.Kinetic analysis of imparied work-cost performace in jaundied rabbit liver.Res Exp Med.1995;195(5):77. |
| 3. | Morimoto T,Ozawa K.Channges in oxidative phosphrylation adenylate energy charge and respiratory components in chloramphemical treating regenerating rat liver.J Lab Clin Med,1986;107(1):10. |
| 4. | Ozawa K,Yamaoka Y.Changes in hepatic energy charge blood ketone body ratio and indocyanine green clearance in relation to DNA synthesis after hepatectomy.Life Science,1982;11:647. |
| 5. | Gatley ST,Sherratt SA.The synthesis of hippurate from benzoate and glycine by rat liver mitochondria.Biochem J,1977;166(1):39. |
| 6. | Couger ML.Mechanism of bilirubin toxicity on tissue culture cell.Biochem Med,1971;5:1. |
- 1. Aogama H,Kamigama Y,Ukikusa M,et al.Clinical significance of hippurate-synthesizing capacity in surgical patients with liver disease:a metabolic tolerance test.J Lab Clin Med,1986;108(3):456.
- 2. Tanaka A,Feng Z,Inomoto T,et al.Kinetic analysis of imparied work-cost performace in jaundied rabbit liver.Res Exp Med.1995;195(5):77.
- 3. Morimoto T,Ozawa K.Channges in oxidative phosphrylation adenylate energy charge and respiratory components in chloramphemical treating regenerating rat liver.J Lab Clin Med,1986;107(1):10.
- 4. Ozawa K,Yamaoka Y.Changes in hepatic energy charge blood ketone body ratio and indocyanine green clearance in relation to DNA synthesis after hepatectomy.Life Science,1982;11:647.
- 5. Gatley ST,Sherratt SA.The synthesis of hippurate from benzoate and glycine by rat liver mitochondria.Biochem J,1977;166(1):39.
- 6. Couger ML.Mechanism of bilirubin toxicity on tissue culture cell.Biochem Med,1971;5:1.