將100只日本大耳白隨機分為正常對照組（10只），實驗組又分為膽道單純不全梗阻組（45只）和膽道不全梗阻加感染組（45只）。實驗組術(shù)后3、7、14和21天分別動態(tài)檢測膽囊免疫球蛋白（Ig）分泌細胞的含量，并比較其變化。結(jié)果顯示：正常兔膽囊粘膜雖存在Ig分泌細胞，但數(shù)量較少。單純梗阻組3、7和14天膽囊粘膜IgG和IgA分泌細胞無明顯變化，梗阻加感染組各時相Ig分泌細胞明顯高于對照組（P lt;0.001），以IgG分泌細胞最為明顯。細菌抗原的刺激是膽囊Ig分泌細胞特異性增殖的主要因素，膽囊是膽道系統(tǒng)Ig產(chǎn)生的重要場所，膽囊Ig分泌細胞與結(jié)石的形成有密切關(guān)系。
引用本文： 曾勇 ,肖路加,張尚福. 兔膽紅素鈣結(jié)石成石過程中膽囊免疫球蛋白分泌細胞含量的變化. 中國普外基礎(chǔ)與臨床雜志, 1997, 4(2): 75-77. doi: 復制
| 1. | 杭振鑣.電子顯微鏡術(shù)在臨床醫(yī)學中的應用.第1版.重慶:重慶出版社,1988:91. |
| 2. | Tomasi TB,Chodirker WB.Gamma globulins:quantitatine relationship in human serum and nonva scular fluids.Science,1936;142:1080. |
| 3. | Gilman RH,Yong C,Bulger R,et al.Anatomical and lmmunological responese of rabbit gallbladders to bacterial infections.Infect Immun,1982;3:407. |
| 4. | Robert C,Harvey S,Upudhya GA,et al.Immunogllbulins as nucleating proteins in the gallbladder bile of patients with cholesterol gallstones.J Biol Chem,1991;266:13996. |
- 1. 杭振鑣.電子顯微鏡術(shù)在臨床醫(yī)學中的應用.第1版.重慶:重慶出版社,1988:91.
- 2. Tomasi TB,Chodirker WB.Gamma globulins:quantitatine relationship in human serum and nonva scular fluids.Science,1936;142:1080.
- 3. Gilman RH,Yong C,Bulger R,et al.Anatomical and lmmunological responese of rabbit gallbladders to bacterial infections.Infect Immun,1982;3:407.
- 4. Robert C,Harvey S,Upudhya GA,et al.Immunogllbulins as nucleating proteins in the gallbladder bile of patients with cholesterol gallstones.J Biol Chem,1991;266:13996.