作者采用猴制急性壞死性胰腺炎（ANP）模型，觀察腫瘤壞死因子（TNF）以及生長抑素對(duì)猴ANP血漿TNF和猴死亡情況的影響。結(jié)果發(fā)現(xiàn)：猴ANP早期其血漿TNF明顯升高，與猴死亡呈平行關(guān)系；生長抑素可明顯降低TNF含量，使猴死亡率下降，存活時(shí)間延長。提示TNF是AFP早期的重要炎癥介質(zhì)，生長抑素可明顯抑制炎癥反應(yīng)過程，對(duì)猴ANP有確切的治療效果。
引用本文： 楊植,楊志英,唐偉松,趙平. 腫瘤壞死因子在猴急性胰腺炎中的作用及生長抑素的治療效果. 中國普外基礎(chǔ)與臨床雜志, 1996, 3(1): 4-6. doi: 復(fù)制
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- 1. Gerami A.Inflamatory cytokines.Clinical Immunopath,1992;62:S3.
- 2. Camussi G,Albano E,Tetta C,et al.The molecular action of tumor necrosis factor α.Eur J Biochem,1991;202:3.
- 3. 趙平,楊植,唐偉松等.腹腔液淀粉酶測(cè)定在估價(jià)急性胰腺炎病變程度及預(yù)后的作用.第二屆全國普外基礎(chǔ)與臨床研討會(huì)資料會(huì)編.1995:76.
- 4. Pohlman TH.An endothelial cell surface factor induced in vitro by lipopolysaccharide.Interleukin 1 and tumor necrosis factor increases neutrophils adherence by a WB 18-dependent mechanism.J Immunol,1986;136:4548.
- 5. Choi TK,Mok F,Zhan WH,et al.Somatostatin in the treatment of acute pancreatitis:a prospective randomized controlled trial.Gut,1989;30:223.
- 6. Buchler MW,Binder M,Friess H.Role of somatostatin and its analogues in the treatment of acute and chronic pancreatitis.Gut,1994;35(Suppl 3):S15.