對18例結(jié)直腸癌患者采用實體瘤短期體外懸浮細胞培養(yǎng)法進行染色體分析。結(jié)果：染色體結(jié)構(gòu)重排涉及17p、5q、6q（78%、61%、50%），染色體增加頻率最高的是7號、3號（72%、66%），丟失則最常見于17號、5號、18號（50%、44%、33%）。大量標記染色體、雙微體及超倍體核型預(yù)示腫瘤易早期復(fù)發(fā)和轉(zhuǎn)移。此結(jié)果提示：17號、5號及18號染色體畸變與結(jié)直腸癌發(fā)生發(fā)展有密切關(guān)系。非隨機性染色體異常的多樣性和復(fù)雜性更表明大腸癌的發(fā)生是多基因多步驟演變的結(jié)果。
引用本文： 李立,嚴律南,吳言濤,汪林,周宏遠. 結(jié)直腸癌非隨機性染色體異常的研究. 中國普外基礎(chǔ)與臨床雜志, 1996, 3(4): 193-195. doi: 復(fù)制
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- 2. Muleris M,Salmon RJ,Dutrillaux B.Cytogenetics of colorectal adenocarcinomas.Cancer Genet Cytogenet,1990;46:143.
- 3. 邱紅明.遺傳性非息肉病性大腸癌分子病理學(xué)研究進展.國外醫(yī)學(xué)遺傳學(xué)分冊,1995;4:176.
- 4. Alan W.Biochemical markers for colorectal cancer.Surg Clin Nor Am,1993;73:1.
- 5. Wang LM,Patel V,Ghosh L,et al.Mutation in the nm23 gene is associated with metastasis in colorectal cancar.Cancer Res,1993;53:717.
- 6. Ookawak,Sakamoto M,Hirohashi S,et al.Concordant p53 and Dcc alterations and allelic losses on chromosomes 17p and 18q associated with liver metastasis of colorectal carcinomas.Int J Cancer,1993;53:382.
- 7. Marx J.A challenge to p16 gene as a major tumor suppressor.Science,1994;264:1846.