• 浙江醫(yī)科大學(xué)附屬第一醫(yī)院外科 ( 杭州 310003);

采用ABC免疫組織化學(xué)方法對(duì)41例胃癌組織，66例正常胃和良性病變胃組織內(nèi)癌胚抗原表達(dá)作了研究。結(jié)果顯示：胃癌組織內(nèi)癌胚抗原(CEA)的表達(dá)程度明顯強(qiáng)于正常胃和良性病變胃組織；前者CEA的分布形式多呈胞漿型和間質(zhì)型，而后者則呈腔緣型和膜型。同時(shí)表明組織內(nèi)CEA的分布形式與腫瘤細(xì)胞的生長(zhǎng)方式和浸潤(rùn)深度有關(guān)。作者認(rèn)為組織內(nèi)CEA的表達(dá)狀況與胃癌細(xì)胞生物學(xué)行為有關(guān)，其在組織內(nèi)的分布形式較其含量更為重要，相同組織學(xué)類型CEA亦可有不同的分布形式。

引用本文： 梁廷波,鄭樹(shù)森,孫義國(guó),于吉人,林建燦. 癌胚抗原的表達(dá)與胃癌細(xì)胞生物學(xué)行為的關(guān)系研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 1996, 3(3): 156-159. doi: 復(fù)制

1. 徐光煒.胃癌.第1版.北京：人民衛(wèi)生出版社，1987：289～300.
2. Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
3. Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
4. Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
5. Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
6. 張蔭昌.胃病理及胃黏膜活檢.第1版.沈陽(yáng)：遼寧科學(xué)技術(shù)出版社，1988：82.
7. Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
8. Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
9. Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
10. Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
11. Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
12. Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
13. Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.
  1. 1. 徐光煒.胃癌.第1版.北京：人民衛(wèi)生出版社，1987：289～300.
  2. 2. Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
  3. 3. Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
  4. 4. Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
  5. 5. Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
  6. 6. 張蔭昌.胃病理及胃黏膜活檢.第1版.沈陽(yáng)：遼寧科學(xué)技術(shù)出版社，1988：82.
  7. 7. Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
  8. 8. Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
  9. 9. Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
  10. 10. Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
  11. 11. Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
  12. 12. Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
  13. 13. Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.