用犬制作膽道梗阻模型，觀察梗阻后不同時(shí)相犬十二指腸和回盲部需氧菌的變化，并對(duì)其腸壁進(jìn)行組織學(xué)與超微結(jié)構(gòu)觀察，以探討膽道梗阻對(duì)小腸菌群的影響和腸道菌群在膽道感染等內(nèi)源性感染中的作用。結(jié)果顯示：隨犬膽道梗阻時(shí)間的延長(zhǎng)，小腸菌群發(fā)生不同程度的變化，表現(xiàn)為細(xì)菌的輕度增殖，定殖菌種數(shù)增多，下段小腸細(xì)菌（主要是大腸桿菌）移位到十二指腸，使十二指腸內(nèi)總需氧菌和大腸桿菌的定殖率明顯增高；回腸粘膜充血水腫、炎細(xì)胞浸潤(rùn)、上皮微絨毛減少。破環(huán)等病理改變。由此表明，膽道梗阻時(shí)腸菌失調(diào)和腸粘膜屏障的破環(huán)可能與膽道梗阻時(shí)膽道感染發(fā)生率高有著密切關(guān)系。因此臨床上在及時(shí)解除膽道梗阻的同時(shí)，還應(yīng)注意調(diào)整膽道梗阻患者的腸道菌群平衡，阻止下消化道細(xì)菌上行定植，以防止腸源性感染的發(fā)生。
引用本文： 江藝,吳愛(ài)平. 膽道梗阻對(duì)犬小腸菌群的影響. 中國(guó)普外基礎(chǔ)與臨床雜志, 1995, 2(3): 132-135. doi: 復(fù)制
| 1. | Stacey M,Webb M.Stadies on the antibacterial properties of the acids and some compounds derived from cholanic acid.Proc Roy Soc,1947;134:523. |
| 2. | Burke V,Stone DE,Beaman J,Gracey M.Effects of biliary diversion on intestinal microflora in the rat.J Med Microbiol,1977;10:244. |
| 3. | Sacquet E,Raibaud D.Etude comparee de la microflora de Ⅰ’ estomac, de Ⅰ’ intestin grele et du caecum du rat holoxenique,et de ses modifications a la suite de diverses,interventions chirurgicales:anse avengle jejunale,deviations biliaires.Annle Inst Pasteus Paris,1971;121:501. |
| 4. | Brown WR,Savage DC,Dubois RS,et al.Intestinal microflora of immunoglobulin-deficient and human subjects.Gastroenterol,1972;62:1143. |
| 5. | Deitch EA,Sttig K,Ma Li,et al.Obstructive jaundice promotes bacterial translocation from the gut.Am J Surg,1990;159:79. |
| 6. | Househam KC.Duodenal microflora in infants with acute diarrheal diease.J Padiatr Gastroenterol Nutr,1986;5:721. |
- 1. Stacey M,Webb M.Stadies on the antibacterial properties of the acids and some compounds derived from cholanic acid.Proc Roy Soc,1947;134:523.
- 2. Burke V,Stone DE,Beaman J,Gracey M.Effects of biliary diversion on intestinal microflora in the rat.J Med Microbiol,1977;10:244.
- 3. Sacquet E,Raibaud D.Etude comparee de la microflora de Ⅰ’ estomac, de Ⅰ’ intestin grele et du caecum du rat holoxenique,et de ses modifications a la suite de diverses,interventions chirurgicales:anse avengle jejunale,deviations biliaires.Annle Inst Pasteus Paris,1971;121:501.
- 4. Brown WR,Savage DC,Dubois RS,et al.Intestinal microflora of immunoglobulin-deficient and human subjects.Gastroenterol,1972;62:1143.
- 5. Deitch EA,Sttig K,Ma Li,et al.Obstructive jaundice promotes bacterial translocation from the gut.Am J Surg,1990;159:79.
- 6. Househam KC.Duodenal microflora in infants with acute diarrheal diease.J Padiatr Gastroenterol Nutr,1986;5:721.