1993年10月至1994年2月對(duì)中—長鏈脂肪乳劑(實(shí)驗(yàn)組，n=40)和長鏈脂肪乳劑(對(duì)照組，n=30)在靜脈營養(yǎng)中的療效進(jìn)行了對(duì)比觀察。從術(shù)后第1天起，除從周圍靜脈輸注必需液體外，每日靜滴中—長鏈或長鏈脂肪乳劑500～1000ml，連續(xù)3～5天。監(jiān)測項(xiàng)目包括血壓、脈搏、呼吸、體溫、血紅蛋白、白細(xì)胞、肝腎功能、血甘油三酯及血膽固醇。結(jié)果顯示：兩組均無全笛反應(yīng)；在輸脂肪乳劑后6小時(shí)，兩組血甘油三酯含量均明顯升高，并于12小時(shí)時(shí)達(dá)峰值，16小時(shí)時(shí)已明顯下降，但對(duì)照組明顯高于實(shí)驗(yàn)組(P lt;0.05)，24小時(shí)時(shí)仍維持較高水平。由此表明，中—長鏈肪乳劑較易從血清中清除；中鏈甘油三酯能快速進(jìn)入線粒體被氧化供能，不依賴內(nèi)毒堿的轉(zhuǎn)運(yùn)，能經(jīng)肝臟生成更多的酮體，極少再脂化為脂肪貯存起來。
引用本文： 時(shí)德,胡羅莉,黃萍,涂天喜,王子偉,孫英信. 中—長鏈脂肪乳劑與長鏈脂肪乳劑在靜脈營養(yǎng)中的療效比較. 中國普外基礎(chǔ)與臨床雜志, 1994, 1(2): 100-103. doi: 復(fù)制
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- 1. Fan ST, Wang J. Metabolic clearance of a fat emulsion containig medium-chain triglycerides in cirrbotic patients. JPEN, 1992;16:279.
- 2. Carpentier BA, Richelle M, Haumont D, et al. New development in fat emulsion.Proceeding Natr Sociery, 1990;49:375.
- 3. Wichlayr M, Baldermann H, Rett K, et al. Comparison of metabolic clearance rates of MCT/LCT and LCT emulsions in diabetics, JPEN, 1988;12:68.
- 4. 楊乃發(fā)，蔣朱明.輸入不同鏈長的脂肪乳劑后血中酮的動(dòng)態(tài)觀察.中國醫(yī)學(xué)科學(xué)院學(xué)報(bào)，1992；6：424.
- 5. Ball MJ, White K.Comparison of medium and long chain riglyceride metabolism in intensive care patients on parenteral nutrition. Intensive Cate Med, 1989;15:250.
- 6. Gordon L, Jensen GL, Edward A, et al. Parenteral infusion of long-and medium-chain trilgycerides and reticulo-endothelial system function in man.JPEn, 1990;14:47.
- 7. Sedman PC, Ramsden CW, Brenman CW, et al. Pharmacological concentrations of lipid emusions inhibit interleukin-2 dependent lymphocyte responsed in vitro.JPEN, 1990;14:12.
- 8. Selman PC, Brenman S, Somer S, et al. Effects of different lipid emulsion on lymphoxyte function during total parenteral nutrition.Br J Surg, 1991;78:1396.
- 9. Maiz A, Yamazaki K, Sabrado J, et al. Peotein metacolism during total parenteral nutrition in injured rats using medium chain triglycerides. Metabolism, 1984;33:901.