• 邢臺市人民醫(yī)院呼吸科（河北邢臺 054001）;

在運(yùn)動醫(yī)學(xué)界，有一種運(yùn)動作為誘發(fā)哮喘唯一因素的運(yùn)動性疾病，稱為運(yùn)動性哮喘（EIA），是哮喘的特殊類型，發(fā)病地點(diǎn)多在運(yùn)動場，起病較急，可危及運(yùn)動員的生命，其發(fā)病機(jī)制至今尚未完全明了。速尿是一種袢利尿劑，也是15-羥前列腺素脫氫酶抑制劑，吸入速尿后對特應(yīng)性和非特應(yīng)性哮喘所致的支氣管收縮有對抗作用[1]。目前國內(nèi)尚未見應(yīng)用速尿防治EIA的臨床報道。我們通過觀察患者吸入速尿前后、運(yùn)動前后肺功能指標(biāo)第1秒用力呼氣容積（FEV1）占預(yù)計值百分比（FEV1%pred）及峰流速（PEF）的變化，探討霧化吸入速尿?qū)IA的防治作用。

引用本文： 王志華. 霧化吸入速尿防治運(yùn)動性哮喘的臨床研究. 中國呼吸與危重監(jiān)護(hù)雜志, 2007, 6(1): 62-63. doi: 復(fù)制

1. Shimizu T，Mochizuki H，Morikawa A，et al.Inhaled furosemide prevents ultrasonically nebulized water bronchoconstricition in children with both atopic and nonatopic asthma.Chest，1993，104：1723-1726.
2. Eggleston PA，Rosenthal RR，Anderson SA，et al.Guidelines for the methodlody of exercise challenge in asthmaties.J Allergy Clin Immunol，1979，64：642-645.
3. Cypcar D，Lemanske RF Jr.Asthma and exercise.Clin Chest Med，1994，15：351-367.
4. Rupp NT，Guill MF，Brudno DS.Unrecognized exercise-induced bronchospasm in adolescent athletes.Am J Dis Child，1992，146：941-944.
5. Inman MD，Watson RM，Killian KJ，et al.Methacholine airway responsiveness decreases during exercise in asthmatic subjects.Am Rev Respir Dis，1990，141：1414-1417.
6. Parvord ID，Wisniewski A，Tatterfield AE.Inhaled frusemide and exercise induced asthma：evidence of a role for inhibitory prostanoids.Thorax，1992，47：797-800.
7. Miyanoshita A，Terada M，Endou H.Furosemide directly stimulates prostaglandin E2 production in the thick ascending limb of Henle’s loop.J Pharmacol Exp Ther，1989，251：1155-1159.
8. McFadden ER Jr.Hypothesis：Esercise-induced asthma as a vascular phenomenon.Lancet，1990，335：880-883.
9. Bianco S，Vajhi A，Robushi M，et al.Prevention of exerciseinduced bronchoconstriction by inhaled frusemide.Lancet，1988，2：252-255.
  1. 1. Shimizu T，Mochizuki H，Morikawa A，et al.Inhaled furosemide prevents ultrasonically nebulized water bronchoconstricition in children with both atopic and nonatopic asthma.Chest，1993，104：1723-1726.
  2. 2. Eggleston PA，Rosenthal RR，Anderson SA，et al.Guidelines for the methodlody of exercise challenge in asthmaties.J Allergy Clin Immunol，1979，64：642-645.
  3. 3. Cypcar D，Lemanske RF Jr.Asthma and exercise.Clin Chest Med，1994，15：351-367.
  4. 4. Rupp NT，Guill MF，Brudno DS.Unrecognized exercise-induced bronchospasm in adolescent athletes.Am J Dis Child，1992，146：941-944.
  5. 5. Inman MD，Watson RM，Killian KJ，et al.Methacholine airway responsiveness decreases during exercise in asthmatic subjects.Am Rev Respir Dis，1990，141：1414-1417.
  6. 6. Parvord ID，Wisniewski A，Tatterfield AE.Inhaled frusemide and exercise induced asthma：evidence of a role for inhibitory prostanoids.Thorax，1992，47：797-800.
  7. 7. Miyanoshita A，Terada M，Endou H.Furosemide directly stimulates prostaglandin E2 production in the thick ascending limb of Henle’s loop.J Pharmacol Exp Ther，1989，251：1155-1159.
  8. 8. McFadden ER Jr.Hypothesis：Esercise-induced asthma as a vascular phenomenon.Lancet，1990，335：880-883.
  9. 9. Bianco S，Vajhi A，Robushi M，et al.Prevention of exerciseinduced bronchoconstriction by inhaled frusemide.Lancet，1988，2：252-255.