抗生素的降階梯治療（de-escalation therapy）是近年來(lái)提出的用于治療重癥肺部感染的一個(gè)策略，在臨床研究和實(shí)踐中能夠有效地提高重癥感染治療的成功率，降低病死率，同時(shí)降低住院時(shí)間和費(fèi)用，是感染治療策略的一大進(jìn)展。本文就這一策略的概念演變和應(yīng)用時(shí)機(jī)作一介紹
引用本文： 印潔,施毅. 降階梯治療在重癥肺部感染治療中的地位. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2008, 08(1): 9-12. doi: 復(fù)制
| 1. | Kollef MH，Sherman G，Ward S，et al.Inadequate antimicrobial treatment of infections：a risk factor for hospital mortality among critically ill patients.Chest，1999，115：462-474. |
| 2. | 中華醫(yī)學(xué)會(huì)呼吸病學(xué)分會(huì).社區(qū)獲得性肺炎診斷和治療指南.中華結(jié)核和呼吸雜志，2006，29：651-655. |
| 3. | Ben-David D，Rubinstein E.Appropriate use of antibiotics for respiratory infections：review of recent statements and position papers.Curr Opin Infect Dis，2002，15：151-156. |
| 4. | Colodner R，Rock W，Chazan B，et al.Risk factors for the development of extended-spectrum beta-lactamase-producing bacteria in nonhospitalized patients.Eur J Clin Microbiol Infect Dis，2004，23：163-167. |
| 5. | Paramythiotou E，Lucet JC，Timsit JF，et al.Acquisition of multidrug-resistant Pseudomonas aeruginosa in patients in intensive care units：role of antibiotics with antipseudomonal activity.Clin Infect Dis，2004，38：670-677. |
| 6. | Munday CJ，Whitehead GM，Todd NJ，et al.Predominance and genetic diversity of community- and hospital-acquired CTX-M extended-spectrum beta-lactamases in York，UK.J Antimicrob Chemother，2004，54：628-633. |
| 7. | Woodford N，Ward ME，Kaufmann ME，et al.Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK.J Antimicrob Chemother，2004，54：735-743. |
| 8. | Valverde A，Coque TM，Sánchez-Moreno MP，et al.Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain.J Clin Microbiol，2004，42：4769-4775. |
| 9. | Livermore DM.The need for new antibiotics.Clin Microbiol Infect，2004，10（Suppl 4）：1-9. |
| 10. | Paterson DL."Collateral damage" from cephalosporin or quinolone antibiotic therapy.Clin Infect Dis， 2004，38（Suppl 4）：S341-S345. |
- 1. Kollef MH，Sherman G，Ward S，et al.Inadequate antimicrobial treatment of infections：a risk factor for hospital mortality among critically ill patients.Chest，1999，115：462-474.
- 2. 中華醫(yī)學(xué)會(huì)呼吸病學(xué)分會(huì).社區(qū)獲得性肺炎診斷和治療指南.中華結(jié)核和呼吸雜志，2006，29：651-655.
- 3. Ben-David D，Rubinstein E.Appropriate use of antibiotics for respiratory infections：review of recent statements and position papers.Curr Opin Infect Dis，2002，15：151-156.
- 4. Colodner R，Rock W，Chazan B，et al.Risk factors for the development of extended-spectrum beta-lactamase-producing bacteria in nonhospitalized patients.Eur J Clin Microbiol Infect Dis，2004，23：163-167.
- 5. Paramythiotou E，Lucet JC，Timsit JF，et al.Acquisition of multidrug-resistant Pseudomonas aeruginosa in patients in intensive care units：role of antibiotics with antipseudomonal activity.Clin Infect Dis，2004，38：670-677.
- 6. Munday CJ，Whitehead GM，Todd NJ，et al.Predominance and genetic diversity of community- and hospital-acquired CTX-M extended-spectrum beta-lactamases in York，UK.J Antimicrob Chemother，2004，54：628-633.
- 7. Woodford N，Ward ME，Kaufmann ME，et al.Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK.J Antimicrob Chemother，2004，54：735-743.
- 8. Valverde A，Coque TM，Sánchez-Moreno MP，et al.Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain.J Clin Microbiol，2004，42：4769-4775.
- 9. Livermore DM.The need for new antibiotics.Clin Microbiol Infect，2004，10（Suppl 4）：1-9.
- 10. Paterson DL."Collateral damage" from cephalosporin or quinolone antibiotic therapy.Clin Infect Dis， 2004，38（Suppl 4）：S341-S345.