目的 檢測(cè)胰島素樣生長(zhǎng)因子結(jié)合蛋白-3（IGFBP-3）在非小細(xì)胞肺癌患者血清與支氣管肺泡灌洗液中的表達(dá)，探討其在肺癌診斷及預(yù)后中的臨床意義。方法 運(yùn)用免疫放射法（IRMA）檢測(cè)80例非小細(xì)胞肺癌患者，14例健康人外周血血清與支氣管肺泡灌洗液（BALF）中IGFBP-3的水平。結(jié)果 肺癌組血清與支氣管肺泡灌洗液中IGFBP-3的表達(dá)顯著低于健康組（P lt;0.05），在有淋巴結(jié)轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移及TNMⅢ~TNMⅣ的肺癌患者血清中，IGFBP-3的下降比無轉(zhuǎn)移者及TNMⅠ~TNMⅡ期者顯著（P lt;0.05）。肺癌組血清中IGFBP-3濃度分別與BALF中IGFBP-3濃度呈正相關(guān)（r=0.415，r=0.355，P均 lt;0.01）。結(jié)論 檢測(cè)患者血清與支氣管肺泡灌洗液IGFBP-3的表達(dá)水平對(duì)肺癌的診斷、判斷預(yù)后是有用的指標(biāo)。
引用本文： 皮佳俐 ,徐平,宋衛(wèi)東,劉媛媛. 胰島素樣生長(zhǎng)因子結(jié)合蛋白-3在肺癌患者中的測(cè)定及其臨床意義. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2008, 08(1): 57-60. doi: 復(fù)制
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- 2. Li BD，Khosravi MJ，Berkel HJ，et al.Free insulin-like growth factor-I and breast cancer risk.Int J Cancer，2001，91：736-739.
- 3. Baxter RC.Signalling pathways involved in antiproliferative effects of IGFBP-3：a review.Mol Pathol，2001，54：145-148.
- 4. Rajah R，Valentinis B，Cohen P.Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism.J Biol Chem，1997，272：12181-12188.
- 5. Hochscheid R，Jaques G，Wegmann B.Transfection of human insulin-like growth factor-binding protein-3 gene inhibits cell growth and tumorigenicity：a cell culture model for lung cancer.J Endocrinol，2000，166：553-563.
- 6. Butt AJ，F(xiàn)irth SM，King MA，et al.Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.J Biol Chem，2000，275：39174-39181.
- 7. Devi GR，Sprenger CC，Plymate SR，et al.Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.Prostate，2002，51：141-152.
- 8. MacDonald RG，Schaffer BS，Kang IJ，et al.Growth inhibition and differentiation of the human colon carcinoma cell line，Caco-2，by constitutive expression of insulin-like growth factor binding protein-3.J Gastroenterol Hepatol，1999，14：72-78.
- 9. Buckbinder L，Talbott R，Velasco-Miguel S，et al.Induction of the growth inhibitor IGF-binding protein 3 by p53.Nature，1995，377：646-649.
- 10. Christoph F，Weikert S，Kempkensteffen C，et al.Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications.Clin Cancer Res，2006，12：5040-5046.