目的 討89Sr治療肺癌多發(fā)骨轉(zhuǎn)移的臨床療效。方法 30例肺癌多發(fā)骨轉(zhuǎn)移患者予以肘靜脈注射89SrCl2 148 MBq/例次,治療后第28 d,觀察疼痛強(qiáng)度(通過劃線法和止痛藥的使用情況評(píng)價(jià)),通過同位素全身骨掃描骨轉(zhuǎn)移灶數(shù)目、尿吡啶酚(PYD)和脫氧吡啶酚(DPD)水平的變化進(jìn)行療效評(píng)價(jià)。結(jié)果 與治療前比較,治療28 d后疼痛強(qiáng)度顯著緩解(P lt;0.001),疼痛緩解率73.3%,消失率16.6%。骨轉(zhuǎn)移灶數(shù)目減少16例,有效率53.3%,改善程度明顯(P lt;0.001)。PYD和DPD較治療前明顯下降[(62.48±37.25)比(100.15±48.65)nmol/mmol Cr,(13.94±8.66)比(31.25±15.32)nmol/mmol Cr,P均 lt;0.001]。結(jié)論 89Sr可有效緩解肺癌多發(fā)骨轉(zhuǎn)移的骨痛,減少骨轉(zhuǎn)移灶數(shù)量,提高患者生活質(zhì)量。
引用本文: 胥杰,陳曉. 89Sr治療30例肺癌多發(fā)骨轉(zhuǎn)移的療效觀察. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2008, 08(2): 104-106. doi: 復(fù)制
版權(quán)信息: ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)呼吸與危重監(jiān)護(hù)雜志》版權(quán)所有,未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
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- 1. Ashayeri E,Omogbehin A,Sridhar R,et al.Strontium 89 in the treatment of pain due to diffuse osseous metastases:a university hospital experience.J Natl Med Assoc,2002,94:706-711.
- 2. 郭永忠,張峰.尿脫氧吡啶酚是新的骨吸收生化指標(biāo).醫(yī)學(xué)綜述,2000,6:7-9.
- 3. Finlay IG,Mason MD,Shelley M.Radioisotopes for the palliation of metastatic bone cancer:a systematic review.Lancet Oncol,2005,6:392-400.
- 4. Ron IG,Stav O,Vishne T,et al.The correlation between palliation of bone pain by intravenous strontium-89 and external beam radiation to linked field in patients with osteoblastic bone metastases.Am J Clin Oncol,2004,27:500-504.
- 5. Lam MG,de Klerk JM,van Rijk PP,et al.Bone seeking radiopharmaceuticals for palliation of pain in cancer patients with osseous metastases.Anticancer Agents Med Chem,2007,7:381-397.