• 第四軍醫(yī)大學(xué)西京醫(yī)院呼吸內(nèi)科(陜西西安 710032);

目的  觀察冷基循環(huán)微波聚能刀(PMCT)聯(lián)合化療治療晚期非小細(xì)胞肺癌(NSCLC)的療效和對(duì)患者生活質(zhì)量的影響。方法  80例NSCLC患者隨機(jī)分為PMCT聯(lián)合化療組和單純化療組,每組40例,兩組化療方案均為順鉑+艾素。比較兩組半年期的臨床療效、生存率和生活質(zhì)量評(píng)分。結(jié)果  PMCT聯(lián)合化療組和單純化療組患者治療3個(gè)月后的有效率分別為52.5%(21/40)和32.5%(13/40),有顯著差異(P lt;0.05)。PMCT聯(lián)合化療組治療半年生存率為87.5%(35/40),單純化療組患者半年生存率為62.5%(25/40),差異有統(tǒng)計(jì)學(xué)意義(P lt;0.05)。PMCT聯(lián)合化療組治療6個(gè)月后生活質(zhì)量總評(píng)分為(143.6±2.4)分,KPS評(píng)分為(93±4)分;單純化療組治療6個(gè)月后生活質(zhì)量總評(píng)分為(121.5±3.5)分,KPS評(píng)分為(79±3)分,差異有統(tǒng)計(jì)學(xué)意義(P均 lt;0.05)。結(jié)論  PMCT聯(lián)合化療治療晚期NSCLC療效優(yōu)于常規(guī)化療。

引用本文: 遆新宇,李圣青,劉阿茹,歐陽海峰,趙峰,吳昌歸. 冷基循環(huán)微波聚能刀聯(lián)合化療與單純化療治療晚期非小細(xì)胞肺癌的近期療效比較. 中國呼吸與危重監(jiān)護(hù)雜志, 2008, 08(3): 174-176. doi: 復(fù)制

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6. Wright AS,Lee FT Jr,Mahvi DM.Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis.Ann Surg Oncol,2003,10:275-283.
7. Dong BW,Zhang J,Liang P,et al.Sequential pathological and immunologic analysis of percutaneous microwave coagulation therapy of hepatocellular carcinoma.Int J Hyperthermia,2003,19:119-133.
8. Zhang J,Dong B,Liang P,et al.Significance of changes in local immunity in patients with hepatocellular carcinoma after percutaneous microwave coagulation therapy.Chin Med J(Engl),2002,115:1367-1371.
9. 周彩存.晚期肺癌的姑息治療.中國呼吸與危重監(jiān)護(hù)雜志,2005,4:177-178.
  1. 1. El·Sherif A,Luketich JD,Landreneau RJ,et al.New therapeutic approaches for early stage non·small cell lung cancer.Surg Oncol,2005,14:27-32.
  2. 2. Dupuy DE,Zagoria RJ,Akerley W,et al.Percutaneous radiofrequency tissue ablation malignancies in the lung.AJR,2000,174:57-59.
  3. 3. Simon CJ,Dupuy DE.Current role of image·guided ablative therapies in lung cancer.Expert Rev Anticancer Ther,2005,5:657-666.
  4. 4. Lu S,Liao ML,Shen J,et al.The possibility to establish the scale of quality life fit for Chinese lung cancer patients.Chin J Lung Cancer,2001,4:344-346.
  5. 5. 孫燕,周際昌,主編.臨床腫瘤內(nèi)科手冊(cè).北京:人民衛(wèi)生出版社,2003,34-37.
  6. 6. Wright AS,Lee FT Jr,Mahvi DM.Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis.Ann Surg Oncol,2003,10:275-283.
  7. 7. Dong BW,Zhang J,Liang P,et al.Sequential pathological and immunologic analysis of percutaneous microwave coagulation therapy of hepatocellular carcinoma.Int J Hyperthermia,2003,19:119-133.
  8. 8. Zhang J,Dong B,Liang P,et al.Significance of changes in local immunity in patients with hepatocellular carcinoma after percutaneous microwave coagulation therapy.Chin Med J(Engl),2002,115:1367-1371.
  9. 9. 周彩存.晚期肺癌的姑息治療.中國呼吸與危重監(jiān)護(hù)雜志,2005,4:177-178.
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