目的 總結(jié)汶川地震中應(yīng)用內(nèi)毒素吸附治療膿毒癥患者的效果。方法 對2例地震膿毒癥患者應(yīng)用多粘菌素B結(jié)合纖維(PMX)進行內(nèi)毒素吸附。結(jié)果 2例患者經(jīng)內(nèi)毒素吸附療法
治療后病情好轉(zhuǎn)，生命體征穩(wěn)定。結(jié)論 PMX吸附內(nèi)毒素對膿毒癥患者是一項很有前景的治療措施。
引用本文： 周琰,梁鵬,黃琨,吳小東,康焰. 內(nèi)毒素吸附治療汶川大地震中的膿毒癥患者. 中國呼吸與危重監(jiān)護雜志, 2008, 08(4): 259-262. doi: 復(fù)制
| 1. | O’Reilly M,Newcomb D E,Remck D ,et al.Endotoxin sepsis,and the primrose path.Shock,1999,12:411-420. |
| 2. | Kastow sky M，Gutberlet T，Bradaczek H.Molecular modelling of the three dimensional structure and conformational flexibility of bacterial lipopolysaccharide.Bacterial,1992,174:4798. |
| 3. | Raetz CRH.Biochemistry of endotoxins.Annu Rev Biochem，1990,59∶129. |
| 4. | Deitch EA .Multiple organ failure:pathophysiology and potential future therapy. Ann Surg,1992,216:117. |
| 5. | Deitch EA, Ma WJ, Ma L,et al.Endotoxin induced bacteria Translocation: a study of mechanism. Surgery,1989,106:292. |
| 6. | Cruz DN, Bellomo R, Ronco C.Clinical effects of polymyxin B immobilized fiber column in septic patients.Contrib Nephrol,2007,156:444-451. |
| 7. | Shoji H,Minaga M,Sakai Y,et al.Design and development of endotoxin detoxifying column PMX and its clinical application.Jpn Art Organs,1993,22:204. |
| 8. | Hanasawa K,Tani T,Kodama M.New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber.Surg Gynecol Obstet,1989,168:323. |
| 9. | Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients.Critical Care Med,1993,21:522. |
| 10. | Andrew M,Calvin B.Reversal of postburn immunosuppression with low dose polymyxin B.Trauma,1986,26:995-998. |
| 11. | Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mononuclear cells,even during activation.Surg Res ,2001,100:127-134. |
| 12. | Kodama M, Hanasawa K, Tani T.Blood purification for critical care medicine: endotoxin adsorption. Ther Apher,1997,1:224-227. |
| 13. | Sato T, Shoji H, Koga N. Endotoxin adsorption by polymyxinB immobilized fiber column in patients with systemic inflammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258. |
- 1. O’Reilly M,Newcomb D E,Remck D ,et al.Endotoxin sepsis,and the primrose path.Shock,1999,12:411-420.
- 2. Kastow sky M，Gutberlet T，Bradaczek H.Molecular modelling of the three dimensional structure and conformational flexibility of bacterial lipopolysaccharide.Bacterial,1992,174:4798.
- 3. Raetz CRH.Biochemistry of endotoxins.Annu Rev Biochem，1990,59∶129.
- 4. Deitch EA .Multiple organ failure:pathophysiology and potential future therapy. Ann Surg,1992,216:117.
- 5. Deitch EA, Ma WJ, Ma L,et al.Endotoxin induced bacteria Translocation: a study of mechanism. Surgery,1989,106:292.
- 6. Cruz DN, Bellomo R, Ronco C.Clinical effects of polymyxin B immobilized fiber column in septic patients.Contrib Nephrol,2007,156:444-451.
- 7. Shoji H,Minaga M,Sakai Y,et al.Design and development of endotoxin detoxifying column PMX and its clinical application.Jpn Art Organs,1993,22:204.
- 8. Hanasawa K,Tani T,Kodama M.New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber.Surg Gynecol Obstet,1989,168:323.
- 9. Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients.Critical Care Med,1993,21:522.
- 10. Andrew M,Calvin B.Reversal of postburn immunosuppression with low dose polymyxin B.Trauma,1986,26:995-998.
- 11. Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mononuclear cells,even during activation.Surg Res ,2001,100:127-134.
- 12. Kodama M, Hanasawa K, Tani T.Blood purification for critical care medicine: endotoxin adsorption. Ther Apher,1997,1:224-227.
- 13. Sato T, Shoji H, Koga N. Endotoxin adsorption by polymyxinB immobilized fiber column in patients with systemic inflammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258.