目的 觀察穩(wěn)定期COPD 患者運(yùn)動(dòng)前后血漿氨基酸末端腦鈉素前體( NT-proBNP) 水平的變化, 探討其變化規(guī)律及臨床意義。方法 受試者為穩(wěn)定期COPD 患者19 例和健康對(duì)照組10 例。分別進(jìn)行遞增功率和恒功率心肺運(yùn)動(dòng)試驗(yàn), 在遞增功率運(yùn)動(dòng)前及運(yùn)動(dòng)高峰時(shí)抽取橈動(dòng)脈血進(jìn)行血?dú)夥治? 在恒功率運(yùn)動(dòng)前及運(yùn)動(dòng)終止即刻抽取肘靜脈血測定血漿中NT-proBNP 的濃度。結(jié)果 穩(wěn)定期COPD 患者在運(yùn)動(dòng)高峰時(shí)的攝氧量、心率、PaO2 及恒功率運(yùn)動(dòng)時(shí)間均明顯低于對(duì)照組; 穩(wěn)定期COPD患者和對(duì)照組運(yùn)動(dòng)前后血漿NT-proBNP 水平差異均無統(tǒng)計(jì)學(xué)意義[ ( 4803. 86 ±1027. 07) ng/L 和( 4572. 39 ±1243. 33) ng/L, P = 0. 542; ( 4303. 18 ±771. 74) ng/L 和( 4475. 71 ±1025. 50) ng/L, P =0. 676] ; 所有受試者血漿NT-proBNP 水平與各運(yùn)動(dòng)指標(biāo)均無顯著相關(guān)性。結(jié)論 運(yùn)動(dòng)對(duì)穩(wěn)定期COPD 患者血漿NT-proBNP 水平無明顯影響, 心功能障礙不是其運(yùn)動(dòng)受限的主要原因。
引用本文： 肖瑤,徐秋芬,王浩彥,樊靜,張玲. COPD患者血漿氨基酸末端腦鈉素前體在運(yùn)動(dòng)中的變化. 中國呼吸與危重監(jiān)護(hù)雜志, 2009, 09(3): 216-219. doi: 復(fù)制
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| 10. | 張洪玉, 楊媛華, 張杰. 慢性肺心病并呼吸衰竭時(shí)左心功能改變. 實(shí)用心腦肺血管病雜志, 1997, 5: 1-2. |
- 1. 徐國賓, 史曉敏. B型鈉尿肽及N 末端B 型鈉尿肽原在臨床應(yīng)用中值得關(guān)注的幾個(gè)問題. 中華檢驗(yàn)醫(yī)學(xué)雜志, 2006, 29: 9-11.
- 2. 姚光, 藍(lán)海云. 腦鈉素對(duì)心源性呼吸困難的診斷價(jià)值. 中國呼吸與危重監(jiān)護(hù)雜志, 2007, 6: 52-54.
- 3. 許小毛, 孫鐵英, 張洪勝. 輕度慢性阻塞性肺疾病患者運(yùn)動(dòng)肺功能的研究. 中國呼吸與危重監(jiān)護(hù)雜志, 2003, 2: 215-218.
- 4. Hunt PJ, Richards AM, Nicholls MG, et al. Immunoreactive aminoterminal pro-brain natriuretic peptide ( NT-PROBNP) : a newmarker of cardiac impairment. Clin Endocrinol, 1997, 47: 287.
- 5. Thaman R, Esteban MT, Barnes S, et al. Usefulness of N-terminal pro-B-type natriuretic peptide levels to predict exercise capacity in hypertrophic cardiomyopathy. AmJ Cardiol, 2006, 98: 515-519.
- 6. Mc Nairy M, Gardetto N, Clopton P, et al. Stability of B-type natriuretic peptide levels during exercise in patients with congestive heart failure: implications for outpatient monitoring with B-type natriuretic peptide. Am Heart J, 2002, 143: 406-411.
- 7. Krüger S, Graf J, Merx MW, et al. Brain natriuretic peptide kinetics during dynamic exercise in patients with chronic heart failure. Int J Cardiol, 2004, 95: 49-54.
- 8. 趙昕. B 型鈉尿肽的生物學(xué)特性及在心臟疾病中的應(yīng)用. 中國老年學(xué)雜志, 2006, 10: 1437-1440.
- 9. Pascual-Figal DA, Pe afiel P, de la Morena G, et al. Relation of Btype natriuretic peptide levels before and after exercise and functional capacity in patients with idiopathic dilated cardiomyopathy. Am J Cardiol, 2007, 99: 1279-1283.
- 10. 張洪玉, 楊媛華, 張杰. 慢性肺心病并呼吸衰竭時(shí)左心功能改變. 實(shí)用心腦肺血管病雜志, 1997, 5: 1-2.