• 南京中醫(yī)藥大學(xué)附屬中西醫(yī)結(jié)合鼓樓臨床醫(yī)學(xué)院ICU( 江蘇南京 210008);

感染性疾病的發(fā)病率高, 給社會經(jīng)濟帶來沉重負擔(dān), 感染性疾病的早期診斷和治療對提高臨床療效和降低死亡率有重要意義。髓樣細胞觸發(fā)性受體1 ( triggering receptor-1
expressed on myeloid cells, TREM-1) 在炎癥反應(yīng)的發(fā)生發(fā)展過程中起著重要的作用。Bouchon 等[ 1] 在2000 年首先發(fā)現(xiàn)TREM-1 選擇性表達于中性粒細胞、CD14 + 單核細胞膜表面。后來的研究發(fā)現(xiàn)TREM-1 也表達于上皮細胞、多核巨細胞、腹膜巨噬細胞、淋巴結(jié)巨噬細胞、肺泡巨噬細胞, 纖維肉瘤細胞膜表面[ 2-5] 。人的TREM-1 由胞外區(qū)、跨膜區(qū)、胞漿區(qū)共同組成, 跨膜區(qū)含有1 個帶正電荷的賴氨酸殘基, 它可與接頭蛋白DAP12 跨膜區(qū)內(nèi)的帶負電荷的天冬氨酸相偶聯(lián), 并通過胞漿區(qū)中的免疫受體酪氨酸活化基序( ITAM) 來激活下游信號傳導(dǎo), 促進促炎因子的分泌[ 6] 。TREM-1 激發(fā)、放大炎癥反應(yīng)的同時促進抗炎因子的下調(diào)[ 1, 2, 7] 。‥‥‥

引用本文： 楊樸強,顧勤,劉寧,虞竹溪. 可溶性髓樣細胞觸發(fā)性受體1 對感染性疾病的診斷價值. 中國呼吸與危重監(jiān)護雜志, 2010, 9(2): 213-215. doi: 復(fù)制

1. Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
2. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
3. Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
4. Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
5. Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
6. Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
7. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
8. Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
9. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
10. Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
11. Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
12. Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
13. Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
14. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
15. Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
16. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
17. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
18. Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
19. Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
20. Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
21. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
22. HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
23. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
24. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
25. , 11: R38.
  1. 1. Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
  2. 2. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
  3. 3. Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
  4. 4. Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
  5. 5. Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
  6. 6. Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
  7. 7. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
  8. 8. Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
  9. 9. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
  10. 10. Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
  11. 11. Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
  12. 12. Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
  13. 13. Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
  14. 14. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
  15. 15. Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
  16. 16. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
  17. 17. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
  18. 18. Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
  19. 19. Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
  20. 20. Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
  21. 21. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
  22. 22. HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
  23. 23. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
  24. 24. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
  25. 25. , 11: R38.