• 解放軍總醫(yī)院南樓呼吸科( 北京 100853);

機械通氣領(lǐng)域目前有幾大爭論, 涉及在機械通氣中基本的也是十分重要的問題, 復習和深入探討這些問題, 對了解機械通氣近年的研究進展, 指導機械通氣的臨床實踐很有意義。

引用本文： 俞森洋. 機械通氣中的幾大爭論和研究進展. 中國呼吸與危重監(jiān)護雜志, 2010, 9(4): 341-343. doi: 復制

1. Matthay MA. Acute lung injury: conference summary. Chest, 1999 ,116 : 119S-126S.
2. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes raditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000 , 342 :1301-1308.
3. Lionetti V, Recchia FA, Ranieri MR. Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit Care, 2005 , 11: 82-86.
4. Esteban A, Ferguson ND,Meade MO, et al. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med, 2008, 177 : 170-177.
5. Goligher E, Fergusor ND. mechanical ventilation: epidemiological insights into current practices. Curr Opin Crit Care,2009, 15: 44-51.
6. Girard TD, Bernard GR. Mechanical ventilation in ARDS: a state-ofthe-art-review. Chest, 2007 , 131: 921-929.
7. Gattinoni L, Chiumello D, Russo R. Reduced tidal volume and lung protected ventilatory strategies: where do we go from here? Curr Opin Crit Care, 2002, 8 : 45-50.
8. MacIntyre NR. Is there a best way to set tidal volume for mechanical ventilatory support? Clin Chest Med, 2008, 29 : 225-231.
9. Terragni PP, Rosboch G, Tealdi A, et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome.Am J Respir Crit Care Med, 2007, 175: 160 -166.
10. Hager DN, Krishnan JA, Hayden DL, et al. tidal volume reduction in patients with acute lung injury when plateau pressures are not high.Am J Respir Crit Care Med, 2005, 172: 1241-1245.
11. Spieth PM, Carvalho AR, Pelosi CP, et al. Variable tidal volumes improve lung pretective ventilation strategies in experimental lung injury. Am J Respir Crit Care Med, 2009 , 179: 684-693 .
12. Gajic O, Dara A, Mendez J, et al. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med, 2004 , 32: 1817.
13. Antonelli M, Azoulay E, Bonten M, et al. Year in review in intensive care medicine, 2008: Ⅱ . experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation. Intensive Care Med, 2009, 35: 215-231.
14. Fan E, Wilcox ME, Brower RG, et al. Recruitment maneuvers for acute lung injury. Am J Respir Crit Care Med, 2008, 178: 1156 -1163.
15. MacIntyre NR. Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?Clin Chest Med, 2008, 29: 233-239 .
16. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Mechanical ventilation with higher versus lower positive end-expiratory pressures in patients with acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2004, 351: 327-336.
17. Sorbo LD, Slutsky AS. Ventilatory support for acute respiratory failure: new and ongoing pathophysiological, diagnostic and therapeutic development. Curr Opin Crit Care, 2010, 16 : 1-7.
18. Grasso S, Stripoli T, De Michele M, et al. ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. AmJ Respir Crit Care Med, 2007, 176 : 761-767.
  1. 1. Matthay MA. Acute lung injury: conference summary. Chest, 1999 ,116 : 119S-126S.
  2. 2. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes raditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000 , 342 :1301-1308.
  3. 3. Lionetti V, Recchia FA, Ranieri MR. Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit Care, 2005 , 11: 82-86.
  4. 4. Esteban A, Ferguson ND,Meade MO, et al. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med, 2008, 177 : 170-177.
  5. 5. Goligher E, Fergusor ND. mechanical ventilation: epidemiological insights into current practices. Curr Opin Crit Care,2009, 15: 44-51.
  6. 6. Girard TD, Bernard GR. Mechanical ventilation in ARDS: a state-ofthe-art-review. Chest, 2007 , 131: 921-929.
  7. 7. Gattinoni L, Chiumello D, Russo R. Reduced tidal volume and lung protected ventilatory strategies: where do we go from here? Curr Opin Crit Care, 2002, 8 : 45-50.
  8. 8. MacIntyre NR. Is there a best way to set tidal volume for mechanical ventilatory support? Clin Chest Med, 2008, 29 : 225-231.
  9. 9. Terragni PP, Rosboch G, Tealdi A, et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome.Am J Respir Crit Care Med, 2007, 175: 160 -166.
  10. 10. Hager DN, Krishnan JA, Hayden DL, et al. tidal volume reduction in patients with acute lung injury when plateau pressures are not high.Am J Respir Crit Care Med, 2005, 172: 1241-1245.
  11. 11. Spieth PM, Carvalho AR, Pelosi CP, et al. Variable tidal volumes improve lung pretective ventilation strategies in experimental lung injury. Am J Respir Crit Care Med, 2009 , 179: 684-693 .
  12. 12. Gajic O, Dara A, Mendez J, et al. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med, 2004 , 32: 1817.
  13. 13. Antonelli M, Azoulay E, Bonten M, et al. Year in review in intensive care medicine, 2008: Ⅱ . experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation. Intensive Care Med, 2009, 35: 215-231.
  14. 14. Fan E, Wilcox ME, Brower RG, et al. Recruitment maneuvers for acute lung injury. Am J Respir Crit Care Med, 2008, 178: 1156 -1163.
  15. 15. MacIntyre NR. Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?Clin Chest Med, 2008, 29: 233-239 .
  16. 16. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Mechanical ventilation with higher versus lower positive end-expiratory pressures in patients with acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2004, 351: 327-336.
  17. 17. Sorbo LD, Slutsky AS. Ventilatory support for acute respiratory failure: new and ongoing pathophysiological, diagnostic and therapeutic development. Curr Opin Crit Care, 2010, 16 : 1-7.
  18. 18. Grasso S, Stripoli T, De Michele M, et al. ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. AmJ Respir Crit Care Med, 2007, 176 : 761-767.