目的 探討肺癌患者血清生長激素釋放肽和瘦素水平的變化及意義。方法 應用放射免疫分析法和酶聯(lián)免疫吸附法( ELISA) 測定46 例肺癌患者血清中生長激素釋放肽和瘦素水平的變化, 并與30 例正常健康人作比較。結(jié)果 肺癌患者血清生長激素釋放肽和瘦素水平均高于正常人( P lt;0. 01) , 且兩者呈正相關(guān)性。結(jié)論 檢測肺癌患者血清生長激素釋放肽和瘦素水平的變化對疾病的監(jiān)測具有重要的臨床價值。
引用本文： 徐春華,于力克,張宇. 肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義. 中國呼吸與危重監(jiān)護雜志, 2010, 9(5): 537-538. doi: 復制
| 1. | Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 . |
| 2. | Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979. |
| 3. | 任珂明, 厲有名. Ghrelin 及其受體在腫瘤發(fā)生中的作用. 國外醫(yī)學· 老年醫(yī)學分冊, 2006, 27 : 196-200. |
| 4. | Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133. |
| 5. | Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660. |
| 6. | Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129. |
| 7. | Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645. |
| 8. | Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423. |
| 9. | Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996. |
| 10. | Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790. |
| 11. | Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 . |
| 12. | Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221. |
- 1. Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
- 2. Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
- 3. 任珂明, 厲有名. Ghrelin 及其受體在腫瘤發(fā)生中的作用. 國外醫(yī)學· 老年醫(yī)學分冊, 2006, 27 : 196-200.
- 4. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
- 5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
- 6. Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
- 7. Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
- 8. Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
- 9. Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
- 10. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
- 11. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
- 12. Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.