• 東南大學(xué)附屬中大醫(yī)院重癥醫(yī)學(xué)科( 江蘇南京 210009);

嚴(yán)重感染及感染性休克是全身性感染( sepsis) 導(dǎo)致的以器官功能損害為特征的復(fù)雜臨床綜合征, 在ICU患者的發(fā)病率高達(dá)25% [1] 。近年來(lái), 盡管抗感染治療及器官功能支持
技術(shù)取得了長(zhǎng)足的進(jìn)步, 但嚴(yán)重感染的病死率仍高達(dá)30% ～70% [2] 。嚴(yán)重感染的發(fā)病機(jī)制復(fù)雜, 免疫功能的紊亂參與嚴(yán)重感染的發(fā)生與發(fā)展。樹突狀細(xì)胞( DCs) 在啟動(dòng)機(jī)體免疫應(yīng)答中發(fā)揮關(guān)鍵性作用。近年研究顯示, 嚴(yán)重感染患者外周血DCs 數(shù)量及功能呈現(xiàn)明顯動(dòng)態(tài)改變, 并與病情嚴(yán)重程度及預(yù)后相關(guān)。因此監(jiān)測(cè)嚴(yán)重感染的危重病患者外周血DCs
改變具有重要的臨床意義。

引用本文： 于晴,劉軍,邱海波. 嚴(yán)重感染患者外周血中樹突狀細(xì)胞的變化及意義. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2010, 9(6): 647-648. doi: 復(fù)制

1. Brun-Buisson C. The epidemiology of the systemic inflammatory response. Intensive Care Med, 2000 , 26: S64-S74 .
2. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from1979 through 2000. N Engl J Med, 2003 ,348 : 1546 -1554 .
3. Kohrgruber N, Halanek N, Groger M, et al. Survival, maturation, and function of CD11c + and CD11c - peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol, 1999 , 163 :3250-3259.
4. Rissoan M, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science, 1999 , 283 :1183-1186.
5. Arpinati M, Green CL, Heimfeld S, et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells.Blood, 2000, 95: 2484-2490.
6. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol, 2000 , 18: 767-811.
7. Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock, 2003 ,20: 386-401 .
8. Zhang Z, Xu DP, Li YG, et al. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunol,2005, 116: 225-235.
9. Poehlmann H, Schefold JC, Zuckermann-Becker H, et al. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Critical Care,2009, 13: 1-12.
10. Takahashi KJ, Satoi S, Yanagimoto H, et al. Circulating dendritic cells and development of septic complications after pancreatectomy for pancreatic cancer. Arch Surg, 2007, 142 : 1151 -1157 .
11. Guisset O, Dilhuydy MS, Thiebaut R, et al. Decrease in circulating dendritic cells predicts fatal outcome in septic shock. Intensive Care Med, 2007, 33: 148-152 .
12. Maier M, Geiger EV, Henrich D, et al. Apoptosis differs in dendritic cell subsets early after severe trauma. Human Immunol, 2009 , 70 :803-808.
13. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Depletion of dendritic cells, but not macrophages, in patients with Sepsis. J Immunol,2002, 168: 2493-2500.
14. Efron PA, Martins A, Minnich D, et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol, 2004, 173: 3035-3043.
15. Rescigno M, Granucci F, Ricciardi-Castagnoli P, et al. Dendritic cells at the end of the millennium. Immunol Cell Biolol, 1999, 77 :404-410.
16. Caux C, Vanbervliet B, Massacrier, et al. Regulation of dendritic cell recruitment by chemokines. Transplantation, 2002, 73: S7-S11.
17. Allavenal P, Piemonti1 L, Longoni D, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol, 1998, 28: 359-369 .
18. Faivre V, Lukaszewicz AC, Alves A, et al. Accelerated in vitro differentiation of blood monocytes into dendritic cells in human sepsis. Clin Exper Immunol, 2007 , 147: 426-439.
19. D′Arpa N, Accardo-Palumbo A, Amato G, et al. Circulating dendritic cells following burn. Burns, 2009, 35: 513 -518.
  1. 1. Brun-Buisson C. The epidemiology of the systemic inflammatory response. Intensive Care Med, 2000 , 26: S64-S74 .
  2. 2. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from1979 through 2000. N Engl J Med, 2003 ,348 : 1546 -1554 .
  3. 3. Kohrgruber N, Halanek N, Groger M, et al. Survival, maturation, and function of CD11c + and CD11c - peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol, 1999 , 163 :3250-3259.
  4. 4. Rissoan M, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science, 1999 , 283 :1183-1186.
  5. 5. Arpinati M, Green CL, Heimfeld S, et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells.Blood, 2000, 95: 2484-2490.
  6. 6. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol, 2000 , 18: 767-811.
  7. 7. Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock, 2003 ,20: 386-401 .
  8. 8. Zhang Z, Xu DP, Li YG, et al. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunol,2005, 116: 225-235.
  9. 9. Poehlmann H, Schefold JC, Zuckermann-Becker H, et al. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Critical Care,2009, 13: 1-12.
  10. 10. Takahashi KJ, Satoi S, Yanagimoto H, et al. Circulating dendritic cells and development of septic complications after pancreatectomy for pancreatic cancer. Arch Surg, 2007, 142 : 1151 -1157 .
  11. 11. Guisset O, Dilhuydy MS, Thiebaut R, et al. Decrease in circulating dendritic cells predicts fatal outcome in septic shock. Intensive Care Med, 2007, 33: 148-152 .
  12. 12. Maier M, Geiger EV, Henrich D, et al. Apoptosis differs in dendritic cell subsets early after severe trauma. Human Immunol, 2009 , 70 :803-808.
  13. 13. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Depletion of dendritic cells, but not macrophages, in patients with Sepsis. J Immunol,2002, 168: 2493-2500.
  14. 14. Efron PA, Martins A, Minnich D, et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol, 2004, 173: 3035-3043.
  15. 15. Rescigno M, Granucci F, Ricciardi-Castagnoli P, et al. Dendritic cells at the end of the millennium. Immunol Cell Biolol, 1999, 77 :404-410.
  16. 16. Caux C, Vanbervliet B, Massacrier, et al. Regulation of dendritic cell recruitment by chemokines. Transplantation, 2002, 73: S7-S11.
  17. 17. Allavenal P, Piemonti1 L, Longoni D, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol, 1998, 28: 359-369 .
  18. 18. Faivre V, Lukaszewicz AC, Alves A, et al. Accelerated in vitro differentiation of blood monocytes into dendritic cells in human sepsis. Clin Exper Immunol, 2007 , 147: 426-439.
  19. 19. D′Arpa N, Accardo-Palumbo A, Amato G, et al. Circulating dendritic cells following burn. Burns, 2009, 35: 513 -518.