目的綜述阿侖膦酸鈉（alendronate，ALN）對(duì)骨關(guān)節(jié)炎（osteoarthritis，OA）關(guān)節(jié)軟骨保護(hù)作用的研究進(jìn)展。 方法廣泛查閱近年國(guó)內(nèi)外相關(guān)文獻(xiàn)，并進(jìn)行綜合分析。 結(jié)果ALN能改善OA關(guān)節(jié)軟骨代謝微環(huán)境，抑制軟骨下骨骨重塑，對(duì)關(guān)節(jié)軟骨有潛在保護(hù)作用。 結(jié)論ALN有望成為一種OA疾病改善藥物，但OA治療尚缺乏統(tǒng)一的基礎(chǔ)與臨床評(píng)價(jià)標(biāo)準(zhǔn)，制定統(tǒng)一標(biāo)準(zhǔn)并獲取臨床數(shù)據(jù)對(duì)ALN的開(kāi)發(fā)和應(yīng)用有指導(dǎo)性意義。
引用本文： 何丁文,殷明,羅元一,魏強(qiáng)強(qiáng). 阿侖膦酸鈉對(duì)骨關(guān)節(jié)炎關(guān)節(jié)軟骨保護(hù)作用的研究進(jìn)展. 中國(guó)修復(fù)重建外科雜志, 2012, 26(10): 1187-1190. doi: 復(fù)制
| 1. | Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250. |
| 2. | 王哲彥, 王文雅, 張柳. 骨性關(guān)節(jié)炎的發(fā)病機(jī)制及其與Wnt/β-catenin信號(hào)通路的關(guān)系. 中國(guó)矯形外科雜志, 2009, 17(23): 1800-1803. |
| 3. | Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243. |
| 4. | Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7. |
| 5. | Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86. |
| 6. | Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412. |
| 7. | Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254. |
| 8. | 胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對(duì)軟骨細(xì)胞的影響及對(duì)兔前交叉韌帶切斷后關(guān)節(jié)軟骨和軟骨下骨的作用. 中國(guó)修復(fù)重建外科雜志, 2009, 23(12): 1474-1481. |
| 9. | 王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對(duì)IL-1β體外誘導(dǎo)培養(yǎng)的大鼠膝關(guān)節(jié)軟骨細(xì)胞影響的實(shí)驗(yàn)研究. 中國(guó)修復(fù)重建外科雜志, 2011, 25(1): 50-55. |
| 10. | Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206. |
| 11. | 谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對(duì)大鼠骨關(guān)節(jié)炎影響的實(shí)驗(yàn)研究. 武漢大學(xué)學(xué)報(bào): 醫(yī)學(xué)版, 2009, 30(1): 66-69. |
| 12. | 婁方勇, 衛(wèi)小春. 阿侖膦酸鈉對(duì)骨質(zhì)疏松大鼠關(guān)節(jié)軟骨的影響. 中國(guó)藥物與臨床, 2009, 9(4): 261-264. |
| 13. | 梁祖建, 李釗, 張還添, 等. 福善美調(diào)控軟骨下骨骨重塑保護(hù)關(guān)節(jié)軟骨的機(jī)制研究. 中國(guó)骨質(zhì)疏松雜志, 2009, 15(3): 206-210. |
| 14. | 李強(qiáng), 張柳, 李震, 等. 阿侖膦酸鈉對(duì)前交叉韌帶切斷大鼠關(guān)節(jié)軟骨退變的影響. 中國(guó)矯形外科雜志, 2010, 18(14): 1200-1204. |
| 15. | 程潭, 張柳, 李震, 等. 阿侖膦酸鈉對(duì)兔膝骨關(guān)節(jié)炎關(guān)節(jié)軟骨及軟骨下骨保護(hù)的作用. 中國(guó)老年學(xué)雜志, 2010, 30(24): 3695-3698. |
| 16. | Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577. |
| 17. | Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243. |
| 18. | Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256. |
| 19. | Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702. |
| 20. | 柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯(lián)合骨肽注射液治療膝骨性關(guān)節(jié)炎療效分析. 中國(guó)誤診學(xué)雜志, 2011, 11(31): 7646-7647. |
| 21. | 李亞芹. 針刀松解術(shù)聯(lián)合阿侖膦酸鈉治療膝關(guān)節(jié)退行性骨病. 臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志, 2011, 10(11): 853, 856. |
| 22. | Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86. |
- 1. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
- 2. 王哲彥, 王文雅, 張柳. 骨性關(guān)節(jié)炎的發(fā)病機(jī)制及其與Wnt/β-catenin信號(hào)通路的關(guān)系. 中國(guó)矯形外科雜志, 2009, 17(23): 1800-1803.
- 3. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
- 4. Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
- 5. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
- 6. Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
- 7. Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
- 8. 胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對(duì)軟骨細(xì)胞的影響及對(duì)兔前交叉韌帶切斷后關(guān)節(jié)軟骨和軟骨下骨的作用. 中國(guó)修復(fù)重建外科雜志, 2009, 23(12): 1474-1481.
- 9. 王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對(duì)IL-1β體外誘導(dǎo)培養(yǎng)的大鼠膝關(guān)節(jié)軟骨細(xì)胞影響的實(shí)驗(yàn)研究. 中國(guó)修復(fù)重建外科雜志, 2011, 25(1): 50-55.
- 10. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
- 11. 谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對(duì)大鼠骨關(guān)節(jié)炎影響的實(shí)驗(yàn)研究. 武漢大學(xué)學(xué)報(bào): 醫(yī)學(xué)版, 2009, 30(1): 66-69.
- 12. 婁方勇, 衛(wèi)小春. 阿侖膦酸鈉對(duì)骨質(zhì)疏松大鼠關(guān)節(jié)軟骨的影響. 中國(guó)藥物與臨床, 2009, 9(4): 261-264.
- 13. 梁祖建, 李釗, 張還添, 等. 福善美調(diào)控軟骨下骨骨重塑保護(hù)關(guān)節(jié)軟骨的機(jī)制研究. 中國(guó)骨質(zhì)疏松雜志, 2009, 15(3): 206-210.
- 14. 李強(qiáng), 張柳, 李震, 等. 阿侖膦酸鈉對(duì)前交叉韌帶切斷大鼠關(guān)節(jié)軟骨退變的影響. 中國(guó)矯形外科雜志, 2010, 18(14): 1200-1204.
- 15. 程潭, 張柳, 李震, 等. 阿侖膦酸鈉對(duì)兔膝骨關(guān)節(jié)炎關(guān)節(jié)軟骨及軟骨下骨保護(hù)的作用. 中國(guó)老年學(xué)雜志, 2010, 30(24): 3695-3698.
- 16. Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
- 17. Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
- 18. Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
- 19. Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
- 20. 柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯(lián)合骨肽注射液治療膝骨性關(guān)節(jié)炎療效分析. 中國(guó)誤診學(xué)雜志, 2011, 11(31): 7646-7647.
- 21. 李亞芹. 針刀松解術(shù)聯(lián)合阿侖膦酸鈉治療膝關(guān)節(jié)退行性骨病. 臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志, 2011, 10(11): 853, 856.
- 22. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.