目的 觀察還原型谷胱甘肽對(duì)急性腎衰竭的療效和安全性。
方法 采取拋硬幣法將23例急性腎衰竭患者隨機(jī)分為治療組（n=10）和對(duì)照組（n=13）。治療組在常規(guī)治療的基礎(chǔ)上給予還原型谷胱甘肽1 200 mg，靜脈滴注，每日1次，療程4周；而對(duì)照組只給予常規(guī)治療。于治療前及治療第1、2、3、4周結(jié)束時(shí)檢測(cè)血肌酐、尿素氮，療程結(jié)束后評(píng)估近端、遠(yuǎn)端腎小管功能。觀察記錄主要臨床癥狀的改善情況及藥物不良反應(yīng)。
結(jié)果 治療組惡心、嘔吐改善時(shí)間及少尿期持續(xù)時(shí)間明顯短于對(duì)照組。治療組血肌酐水平下降幅度雖大于對(duì)照組，但兩組間比較差異無統(tǒng)計(jì)學(xué)意義。療程結(jié)束時(shí)兩組腎小管功能比較，治療組優(yōu)于對(duì)照組。
結(jié)論 還原型谷胱甘肽用于急性腎衰竭的治療，有助于腎功能的早期恢復(fù)。但由于樣本量較小，今后尚需開展更大樣本，更高質(zhì)量的隨機(jī)對(duì)照試驗(yàn)加以驗(yàn)證。
引用本文： 邱紅渝,唐萬欣,陶冶,米緒華,徐原寧,黃頌敏. 還原型谷胱甘肽治療急性腎功能衰竭的隨機(jī)對(duì)照試驗(yàn). 中國(guó)循證醫(yī)學(xué)雜志, 2007, 07(2): 104-107. doi: 復(fù)制
| 1. | Liu P. Acute Renal Failure. In: Wang HY. Nephrology. 2nd eds. Beijing: People’s Medical Publishing House, 1998. 1341. |
| 2. | Nephrol Dial Transplant, 2006; 21(5): 1240–1247. |
| 3. | Chen M, Guo RS, Chen ZY, et al. The protective effect of melatonin in acute ischemia reperfusion renal injury. Chinese Journal Of Nephrology, Dialysis & Transplantation, 1999, 8(1): 27–30. |
| 4. | 劉平. 急性腎功能衰竭. 見: 王海燕, 主編. 腎臟病學(xué). 第2版. 北京: 人民衛(wèi)生出版社, 1998. 1341. |
| 5. | Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. |
| 6. | Polat A, Parlakpinar H, Tasdemir S, Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Act a Histochem, 2006, 108(5): 365–371. |
| 7. | Schumer M, Colombel MC, Sawchuk TS, et al. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol, 1992, 140: 831. |
| 8. | 陳敏, 郭仁壽, 陳重義, 等. 褪黑素在急性腎缺血再灌注損傷中的防治作用及其對(duì)細(xì)胞凋亡的影響. 腎臟病與透析腎移植雜志, 1999, 8(1): 27–30. |
| 9. | Morel G, Bonnet P, Cossec B, et al. The role of glutathione and cysteine conjugates in the nephrotoxicity of oxylene in rats. Archtoxicol, 1998, 72: 553–558. |
- 1. Liu P. Acute Renal Failure. In: Wang HY. Nephrology. 2nd eds. Beijing: People’s Medical Publishing House, 1998. 1341.
- 2. Nephrol Dial Transplant, 2006; 21(5): 1240–1247.
- 3. Chen M, Guo RS, Chen ZY, et al. The protective effect of melatonin in acute ischemia reperfusion renal injury. Chinese Journal Of Nephrology, Dialysis & Transplantation, 1999, 8(1): 27–30.
- 4. 劉平. 急性腎功能衰竭. 見: 王海燕, 主編. 腎臟病學(xué). 第2版. 北京: 人民衛(wèi)生出版社, 1998. 1341.
- 5. Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion.
- 6. Polat A, Parlakpinar H, Tasdemir S, Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Act a Histochem, 2006, 108(5): 365–371.
- 7. Schumer M, Colombel MC, Sawchuk TS, et al. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol, 1992, 140: 831.
- 8. 陳敏, 郭仁壽, 陳重義, 等. 褪黑素在急性腎缺血再灌注損傷中的防治作用及其對(duì)細(xì)胞凋亡的影響. 腎臟病與透析腎移植雜志, 1999, 8(1): 27–30.
- 9. Morel G, Bonnet P, Cossec B, et al. The role of glutathione and cysteine conjugates in the nephrotoxicity of oxylene in rats. Archtoxicol, 1998, 72: 553–558.