陳潔 1 , 楊軍 2 , 楊文蔚 3 , 吳皓 2
  • 1. 上海交通大學醫(yī)學院附屬兒童醫(yī)學中心 耳鼻咽喉–頭頸外科（上海 200127）2. 上海交通大學醫(yī)學院附屬新華醫(yī)院耳鼻咽喉–頭頸外科（上海 200092）3. 上海黃浦區(qū)中心醫(yī)院免疫室（上海 200001）;

目的 　探討阻塞性睡眠呼吸暫停綜合征患兒血清中IL-6和TNF-α的水平及臨床意義。
方法 　納入2005年8月至2006年2月在本院耳鼻咽喉科住院，并接受手術(shù)治療的100例阻塞性睡眠呼吸暫停綜合征（OSAS）患兒和40例自愿接受檢測的正常兒童，測定其血清IL-6和TNF-α的水平。
結(jié)果 　OSAS患兒血清IL-6和TNF-α的水平要明顯高于正常對照組兒童，其差異有統(tǒng)計學意義（P lt;0.05）。但OSAS患兒血清IL-6、TNF-α水平和睡眠紊亂（AHI）指數(shù)之間并無相關(guān)性。
結(jié)論 　兒童OSAS代表著一個慢性炎癥過程，血清IL-6和TNF-α水平的升高與其存在一定的相關(guān)性，并可能是這些患兒以后發(fā)生心血管疾病的一個危險因素。

引用本文： 陳潔,楊軍,楊文蔚,吳皓. 阻塞性睡眠呼吸暫停綜合征患兒血清IL-6和TNF-α檢測及其臨床意義. 中國循證醫(yī)學雜志, 2007, 07(7): 547-549. doi: 復制

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1. Liu YC, Lu XY, Cui ZZ, et al. Epidemiologic survey of 2-12 years children’s sleeping in 8 city of China. Sleep Medicine, 2004, 1(1): 4-7.
2. 劉璽誠, 盧秀英, 崔振澤, 等. 全國8城市2～12歲兒童睡眠狀況流行病學調(diào)查. 睡眠醫(yī)學, 2004, 1(1): 4-7.
3. Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease interleukin-6 and the risk of mortality in order women: The women’ health and aging study. Circulation, 2001, 103(7): 947-953.
4. Schulz R, Mahmoudi S, Hattar K, et al.Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Am J Respir Crit Care Med, 2000, 162(2): 566-570.
5. Monaco C, Andreakos E, Young S, et al. T cell-mediated signaling to vascular endothelium: induction of cytokines,chemokines, and tissue factor. J Leukoc Biol, 2002, 71(4): 659-668 .
6. Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of Creactive protine and Interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway preassure. Circulation, 2003, 107(8): 1129-1134.
7. Riha RL, Brander P, Vennelle M, et al. Tumour necrosis factor- (–308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome. Eur Respir J, 2005, 26(32): 673-678.
8. Biasucci LM, Liuzzo G, Fantuzzi G, et al. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increase tisk of in-hospital coronary events. Circulation, 1999, 99(16): 2079-2084.
9. Vansan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risks of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation, 2003, 107(11): 1486-1491.
10. Tauman R, Ivanenko A, Louise P, et al. Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing. Pediatrics, 2004, 113(6): 564-569.
11. Takuya Y, Minoguchi K, Matsuo H, et al. Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure. Circulation, 2003, 107(11): 1129-1133.
  1. 1. Liu YC, Lu XY, Cui ZZ, et al. Epidemiologic survey of 2-12 years children’s sleeping in 8 city of China. Sleep Medicine, 2004, 1(1): 4-7.
  2. 2. 劉璽誠, 盧秀英, 崔振澤, 等. 全國8城市2～12歲兒童睡眠狀況流行病學調(diào)查. 睡眠醫(yī)學, 2004, 1(1): 4-7.
  3. 3. Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease interleukin-6 and the risk of mortality in order women: The women’ health and aging study. Circulation, 2001, 103(7): 947-953.
  4. 4. Schulz R, Mahmoudi S, Hattar K, et al.Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Am J Respir Crit Care Med, 2000, 162(2): 566-570.
  5. 5. Monaco C, Andreakos E, Young S, et al. T cell-mediated signaling to vascular endothelium: induction of cytokines,chemokines, and tissue factor. J Leukoc Biol, 2002, 71(4): 659-668 .
  6. 6. Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of Creactive protine and Interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway preassure. Circulation, 2003, 107(8): 1129-1134.
  7. 7. Riha RL, Brander P, Vennelle M, et al. Tumour necrosis factor- (–308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome. Eur Respir J, 2005, 26(32): 673-678.
  8. 8. Biasucci LM, Liuzzo G, Fantuzzi G, et al. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increase tisk of in-hospital coronary events. Circulation, 1999, 99(16): 2079-2084.
  9. 9. Vansan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risks of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation, 2003, 107(11): 1486-1491.
  10. 10. Tauman R, Ivanenko A, Louise P, et al. Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing. Pediatrics, 2004, 113(6): 564-569.
  11. 11. Takuya Y, Minoguchi K, Matsuo H, et al. Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure. Circulation, 2003, 107(11): 1129-1133.