• 1. 深圳市中醫(yī)院,深圳,5180332. 四川大學華西醫(yī)院中國循證醫(yī)學中心/國際臨床流行病學網(wǎng)華西研究與培訓中心,成都,610041;

目的 　評價茵梔黃注射液對黃疸型病毒性肝炎的退黃效果與安全性.
方法 　計算機檢索MEDLINE(1966～2005),Cochrane 圖書館(2005年第1期)的臨床對照試驗資料庫、肝病組資料庫,中國生物醫(yī)學文獻數(shù)據(jù)庫(1978～2004),中文生物醫(yī)學期刊文獻數(shù)據(jù)庫(1994～2005),中國醫(yī)學學術會議論文數(shù)據(jù)庫(1994～2005),中國期刊全文數(shù)據(jù)庫(1994～2005),中文科技期刊數(shù)據(jù)庫(1989～2004).納入茵梔黃注射液治療黃疸型病毒性肝炎的隨機對照試驗及半隨機對照試驗,并對其進行質量評價.用RevMan 4.2軟件進行統(tǒng)計分析.
結果 　共納入4個隨機對照試驗.Meta分析結果顯示,對急性肝炎,單用茵梔黃注射液與西藥陽性對照藥相比,茵梔黃注射液的退黃效果比西藥對照藥更優(yōu)或與西藥對照藥相似[WMD-19.70,95%CI(-32.69,-6.71)和WMD-1.27,95%CI(-3.08,0.54)];但對慢性肝炎,茵梔黃注射液的退黃作用要弱于思美泰[WMD-106.00,95%CI(-189.05,-22.95)];自身對照試驗結果顯示,大劑量茵梔黃注射液的退黃作用優(yōu)于小劑量[WMD-11.50,95%CI(-16.53, -6.47)],提示加大用藥劑量,可提高其退黃效率.現(xiàn)有資料未提示有嚴重不良反應發(fā)生.
結論 　茵梔黃注射液對黃疸型病毒性肝炎可能有退黃作用,由于納入的研究存在選擇性偏倚、實施偏倚、測量性偏倚的高度可能性,尚需更多的高質量研究提供可靠的證據(jù)對其療效及安全性予以證實.

引用本文： 陳 軍,陳輝揚,劉志承,吳泰相. 茵梔黃注射液對黃疸型病毒性肝炎的退黃效果與安全性的系統(tǒng)評價. 中國循證醫(yī)學雜志, 2005, 05(6): 461-465. doi: 復制

1. 石理蘭, 張琳, 竇曉光. 病毒性肝炎的診斷[J]. 遼寧藥物與臨床, 2002; 7(2): 64.
2. 中華醫(yī)學會傳染病與寄生蟲病學分會、肝病學分會. 病毒性肝炎防治方案[J]. 中華內科雜志, 2001; 40(1): 62.
3. 史天陸, 陶中原, 黃家倫. 茵梔黃注射液的臨床應用與展望[J]. 基層中藥志, 2000; 14(3): 58.
4. 國家藥品評價中心. 國家基本藥物(中成藥)[M]. 北京: 人民衛(wèi)生出版社, 2003; 417～418.
5. 金英愛, 李英順. 茵梔黃注射液治療病毒性肝炎療效觀察[J]. 中醫(yī)藥學報, 2002; 30(3): 19.
6. 王輝, 劉俊. 茵梔黃、苦黃、古拉定治療急性黃疸型肝炎療效觀察[J]. 云南中醫(yī)學院學報, 2004; 27(1): 31～32.
7. 倪若愚, 張佩弦, 羅端德, 阮峻峰. 茵梔黃注射液治療急性黃疸型肝炎的臨床評價[J]. 醫(yī)藥導報, 1994; 13(3): 106.
8. 謝仕斌, 黃桂梅, 鄧云珍, 謝冬英, 陳幼明, 姚集魯. 腺苷蛋氨酸治療急、慢性病毒性肝炎的臨床療效[J]. 中國新藥雜志, 1999; 8(12): 824～826.
9. 屠德敬, 蘭朝廷, 林維進, 劉盛軍. 茵梔黃注射液治療急性黃疸型肝炎56例療效觀察[J]. 中華實用中西醫(yī)雜志, 2004; 4(17): 7.
10. 崔建華, 趙春紅, 吳志敏. 茵梔黃注射液治療病毒性肝炎高膽紅素血癥38例療效觀察[J]. 中原醫(yī)刊, 2003; 30(2): 50.
11. 陳海明, 李方學. 茵梔黃對病毒性肝炎高膽紅素血癥的影響[J]. 浙江中西醫(yī)結合雜志, 2003; 13(3): 164.
12. Shi LL, Zhang L, Dou XG. Diagnosis of virus hepatitis[J]. Liaoning Medication and Clinic, 2002; 7(2): 64.
13. China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
14. Shi TL, Tao ZY, Huang JL. Clinic applications and expectation of Yinzhihuang Injection[J]. Primary Journal of Chinese Materia Medica, 2000; 14(3): 58.
15. State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
16. Jin YA, Li YS. Curative effect observation of Yinzhihuang injection for virus hepatitis[J]. Acta Chinese Medicine and Pharmacology, 2002; 30(3): 19.
17. Wang H, Liu J. Effect observation of Yinzhihuang injection for acute icteric hepatitis[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2004; 27(1): 31-32.
18. Ni RY, Zhang PX, Luo DD, Ruan JF. Clinical evaluation on Yinzhihuang injection for acute icteric hepatitis[J]. Herald of Medicine, 1994; 13(3): 106.
19. Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews Handbook 4.2.2[Updated December 2003] [M/CD]. In: The Cochrane Library, Ossue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
20. Xie SB, Huang GM, Deng YZ, Xie DY, Chen YM, Yao JL. Observation of S-Adeanosyl methionine therapeutic effect on acute and chronic hepatitis[J]. Chinese New Drugs Journal, 1999; 8(12): 824-826.
21. Tu DJ, Lan CT, Lin WJ, Liu SJ. Curative effect observation on treating acute icteric hepatitis in 56 cases[J]. Chinese Journal of the Practical Chinese with Modern Medicine, 2004; 4(17): 7.
22. Cui JH, Zhao CH, Wu ZM. Observation of Yinzhihuang Injection for icteric virus hepatitis in 38 cases[J]. Central Plains Medical Journal, 2003; 30(2): 50.
23. Chen HM, Li FX. Effect of Yinzhihuang injection for icteric virus hepatitis[J]. Zhejiang Journal of Chinese with Modern Medicine, 2003; 13(3): 164.
  1. 1. 石理蘭, 張琳, 竇曉光. 病毒性肝炎的診斷[J]. 遼寧藥物與臨床, 2002; 7(2): 64.
  2. 2. 中華醫(yī)學會傳染病與寄生蟲病學分會、肝病學分會. 病毒性肝炎防治方案[J]. 中華內科雜志, 2001; 40(1): 62.
  3. 3. 史天陸, 陶中原, 黃家倫. 茵梔黃注射液的臨床應用與展望[J]. 基層中藥志, 2000; 14(3): 58.
  4. 4. 國家藥品評價中心. 國家基本藥物(中成藥)[M]. 北京: 人民衛(wèi)生出版社, 2003; 417～418.
  5. 5. 金英愛, 李英順. 茵梔黃注射液治療病毒性肝炎療效觀察[J]. 中醫(yī)藥學報, 2002; 30(3): 19.
  6. 6. 王輝, 劉俊. 茵梔黃、苦黃、古拉定治療急性黃疸型肝炎療效觀察[J]. 云南中醫(yī)學院學報, 2004; 27(1): 31～32.
  7. 7. 倪若愚, 張佩弦, 羅端德, 阮峻峰. 茵梔黃注射液治療急性黃疸型肝炎的臨床評價[J]. 醫(yī)藥導報, 1994; 13(3): 106.
  8. 8. 謝仕斌, 黃桂梅, 鄧云珍, 謝冬英, 陳幼明, 姚集魯. 腺苷蛋氨酸治療急、慢性病毒性肝炎的臨床療效[J]. 中國新藥雜志, 1999; 8(12): 824～826.
  9. 9. 屠德敬, 蘭朝廷, 林維進, 劉盛軍. 茵梔黃注射液治療急性黃疸型肝炎56例療效觀察[J]. 中華實用中西醫(yī)雜志, 2004; 4(17): 7.
  10. 10. 崔建華, 趙春紅, 吳志敏. 茵梔黃注射液治療病毒性肝炎高膽紅素血癥38例療效觀察[J]. 中原醫(yī)刊, 2003; 30(2): 50.
  11. 11. 陳海明, 李方學. 茵梔黃對病毒性肝炎高膽紅素血癥的影響[J]. 浙江中西醫(yī)結合雜志, 2003; 13(3): 164.
  12. 12. Shi LL, Zhang L, Dou XG. Diagnosis of virus hepatitis[J]. Liaoning Medication and Clinic, 2002; 7(2): 64.
  13. 13. China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
  14. 14. Shi TL, Tao ZY, Huang JL. Clinic applications and expectation of Yinzhihuang Injection[J]. Primary Journal of Chinese Materia Medica, 2000; 14(3): 58.
  15. 15. State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
  16. 16. Jin YA, Li YS. Curative effect observation of Yinzhihuang injection for virus hepatitis[J]. Acta Chinese Medicine and Pharmacology, 2002; 30(3): 19.
  17. 17. Wang H, Liu J. Effect observation of Yinzhihuang injection for acute icteric hepatitis[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2004; 27(1): 31-32.
  18. 18. Ni RY, Zhang PX, Luo DD, Ruan JF. Clinical evaluation on Yinzhihuang injection for acute icteric hepatitis[J]. Herald of Medicine, 1994; 13(3): 106.
  19. 19. Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews Handbook 4.2.2[Updated December 2003] [M/CD]. In: The Cochrane Library, Ossue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
  20. 20. Xie SB, Huang GM, Deng YZ, Xie DY, Chen YM, Yao JL. Observation of S-Adeanosyl methionine therapeutic effect on acute and chronic hepatitis[J]. Chinese New Drugs Journal, 1999; 8(12): 824-826.
  21. 21. Tu DJ, Lan CT, Lin WJ, Liu SJ. Curative effect observation on treating acute icteric hepatitis in 56 cases[J]. Chinese Journal of the Practical Chinese with Modern Medicine, 2004; 4(17): 7.
  22. 22. Cui JH, Zhao CH, Wu ZM. Observation of Yinzhihuang Injection for icteric virus hepatitis in 38 cases[J]. Central Plains Medical Journal, 2003; 30(2): 50.
  23. 23. Chen HM, Li FX. Effect of Yinzhihuang injection for icteric virus hepatitis[J]. Zhejiang Journal of Chinese with Modern Medicine, 2003; 13(3): 164.