• 四川大學華西醫(yī)院,神經(jīng)內(nèi)科,成都,610041;

目的 　了解目前葛根素治療缺血性腦卒中臨床研究的現(xiàn)狀及能否為臨床實踐提供可靠的依據(jù).
方法 　通過機檢和手檢全面收集全世界范圍內(nèi)發(fā)表的有關(guān)葛根素治療缺血性腦卒中的研究文章,并按臨床流行病學標準對納入的文章進行分析.
結(jié)果 　納入隨機對照試驗(RCT)35篇,有對照未隨機分組的試驗22篇,無對照的系列病例觀察17篇.有全國性診斷標準占74.3%,納入標準占9.5%,僅4篇為半隨機分配,余未描述隨機方案.1篇雙盲,2篇單盲,隨訪期均不超過30天.
結(jié)論 　葛根素治療缺血性腦卒中的臨床研究的質(zhì)量低,還不能滿足臨床實踐的需要.

引用本文： 譚燕,劉鳴. 葛根素治療缺血性腦卒中的臨床研究分析. 中國循證醫(yī)學雜志, 2003, 03(3): 207-209. doi: 復制

版權(quán)信息： ?四川大學華西醫(yī)院華西期刊社《中國循證醫(yī)學雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  2. 2. ［2］European stroke initiave. Recommendation for stroke management[J]. Cerebrovascular Diseases 2000;10:335-351.
  3. 3. ［3］王家良.臨床流行病學-臨床科研設(shè)計,衡量與評價[M]第2版上海:上海科學技術(shù)出版社,2001:47-72.
  4. 4. ［4］The standards of reporting trials group. A proposal for structured reporting of randomized controlled trials[J].JAMA 1994;272:1926-1931.
  5. 5. ［5］Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials[J].JAMA 1996;276:637-639.
  6. 6. ［6］Schulz KF, Chalmers I, Hayes R J, et al. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA 1995;273:408-412.
  7. 7. ［7］Duncan PW, Jorgensen HS, Wade DT. Outcome measures in acute stroke trial [J].Stroke 2000;31:1429-1438.
  8. 8. ［8］劉鳴,張世洪新知識:臨床試驗中的意向處理分析[J].英國醫(yī)學雜志中文版2001;4:223-224.