• 四川大學(xué)華西第二醫(yī)院婦產(chǎn)科（成都，610041）;

目的 　通過對1例原發(fā)于宮頸的胎盤部位滋養(yǎng)細胞腫瘤（PSTT）的資料及相關(guān)文獻的復(fù)習(xí)，全面介紹胎盤部位滋養(yǎng)細胞腫瘤的臨床特征、病理特點、治療方式及預(yù)后。 方法 　對收治1例罕見原發(fā)于宮頸部位的PSTT的臨床病理資料進行分析，并以“胎盤部位滋養(yǎng)細胞腫瘤”為主題詞查閱中國知網(wǎng)（CNKI）及PubMed等文獻數(shù)據(jù)庫進行文獻復(fù)習(xí)。 結(jié)果 　該例原發(fā)于宮頸部位的PSTT患者術(shù)后化學(xué)療法后，目前情況良好，已隨訪3年，無復(fù)發(fā)及轉(zhuǎn)移征象。2011年9月1日前，CNKI數(shù)據(jù)庫共報道300余例PSTT病例，PubMed數(shù)據(jù)庫共160余例，其中有2例原發(fā)于宮頸部位的PSTT。原發(fā)于宮頸部位的PSTT罕見，易誤診，往往需要宮頸活組織檢查或?qū)m頸搔刮才能確診。 結(jié)論 　原發(fā)于宮頸部位的PSTT的預(yù)后是否遵循PSTT尚需收集更多的病例證實。PSTT因其發(fā)病率低，臨床表現(xiàn)多無特異性，通常需要通過診斷性刮宮、活組織檢查甚至術(shù)后病理檢查才能確診。PSTT首選的治療方式為手術(shù)，多數(shù)患者病灶清除后可治愈，對有高危因素的患者術(shù)后宜選擇依托泊苷+甲氨蝶呤+放線菌素D+環(huán)磷酰胺+長春新堿（EMA-CO）方案或依托泊苷+甲氨蝶呤+放線菌素D+依托泊苷+順鉑（EMA-EP）方案進行化學(xué)治療，以期改善預(yù)后。

引用本文： 肖萍,尹如鐵,童龍霞,王丹青,李清麗. 宮頸胎盤部位滋養(yǎng)細胞腫瘤一例并文獻復(fù)習(xí). 華西醫(yī)學(xué), 2012, 27(3): 363-367. doi: 復(fù)制

1. 　Kurman RJ, Scully RE, Norris HJ. Trophoblastic psuedotumor of the uterus. An exaggerated form of “synctial endometritis” simulating a malignant tumor[J]. Cancer, 1976, 38(3): 1214-1226.
2. 　Twiggs LB, Okagaki T, Philips GL, et al. Trophoblastic pseudotumor- evidence of malignant disease potential[J]. Gynecol Oncol, 1981, 12(2 Pt 1): 238-248.
3. 　Scully RE, Young RH. Trophoblastic pseudotumor: a reappraisal[J]. Am J Surg Pathol, 981, 5(1): 75-76.
4. 　Schmid P, Nagai Y, Agarwal R, et al. Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study[J]. Lancet, 2009, 374(9683): 48-55.
5. 　石一復(fù), 李娟清, 鄭偉. 360余萬次妊娠中妊娠滋養(yǎng)細胞疾病發(fā)生情況調(diào)查[J]. 中華婦產(chǎn)科雜志, 2005, 40(2): 76-78.
6. 　趙峻, 向陽. 胎盤部位滋養(yǎng)細胞腫瘤及其診治[J]. 實用腫瘤雜志, 2008, 23(1): 5-7.
7. 　Zwischenberger BA, Boren T. Placental site trophoblastc tumor presenting as a friable mass[J]. Eur J Gynaecol Oncol, 2010, 31(5): 570-572.
8. 　Soma H, Okada T, Yoshinari T, et al. Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy[J]. J Obstet Gynaecol Res, 2004, 30(2): 113-116.
9. 　Khan S, Dancey G, Lindsay I, et al. Placental site trophoblastic tumour derived from an oocyte donation pregnancy[J]. BJOG, 2006, 113(3): 344-346.
10. 　Hui P, Wang HL, Chu P, et al. Absence of Y chromosome in human placental site trophoblastic tumor[J]. Modern Pathol, 2007, 20(10): 1055-1060.
11. 　Hui P, Parkash V, Perkins AS, et al. Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome[J]. Lab Invest, 2000, 80(6): 965-972.
12. 　Baergen RN, Rutgers JL, Young RH, et al. Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance[J]. Gynecol Oncol, 2006, 100(3): 511-520.
13. 　Feltmate CM, Genest DR, Wise L, et al. Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center[J]. Gynecol Oncol, 2001, 82(3): 415-419.
14. 　Arroyo MR, Podda A, Cao D, et al. Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty[J]. Pediatr Dev Pathol, 2009, 12(1): 73-76.
15. 　Suurmeijer AJH, Gietema JA, Hoekstra HJ. Placental Site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis[J]. Am J Surg Pathol, 2004, 28(6): 830-833.
16. 　Hassadia A, Gillespie A, Tidy J, et al. Placental site trophoblastic tumour: clinical features and management[J]. Gynecol Oncol, 2005, 99(3): 603-607.
17. 　Ajithkumar TV, Abraham EK, Rejnishkumar R, et al. Placental site trophoblastic tumor[J]. Obstet Gynecol Survey, 2003, 58(7): 484-488.
18. 　Behtash N, Zarchi MK. Placental site trophoblastic tumor[J]. J Cancer Res Clin Oncol, 2008, 134(1): 1-6.
19. 　Chang YL, Chang TC, Hsueh S, et al. Prognostic factors and treatment for placental site trophoblastic tumor- report of 3 cases and analysis of 88 cases[J]. Gynecol Oncol, 1999, 73(2): 216-222.
20. 　Guvendag GES, Guven S, Esinler I, et al. Placental site trophoblastic tumor in a patient with brain and lung metastases[J]. Int J Gynecol Cancer, 2004, 14(3): 558-563.
21. 　Cole LA, Khanlian SA, Muller CY, et al. Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free β-subunit, a reliable marker of placental site trophoblastic tumors[J]. Gynecol Oncol, 2006, 102(2): 160-164.
22. 　Sumi Y, Ozaki Y, Shindoh N, et al. Placental site trophoblastic tumor: imaging findings[J]. Radiat Med, 1999, 17(6): 427-430.
23. 　沈丹華, 廖曉耘, 劉艷麗, 等. 胎盤部位過度反應(yīng)及胎盤部位結(jié)節(jié)的臨床病理分析[J]. 中華病理學(xué)雜志, 2004, 33(5): 441-444.
24. 　趙峻, 向陽, 萬希潤, 等. 胎盤部位滋養(yǎng)細胞腫瘤的臨床病理特征及預(yù)后分析[J]. 中華醫(yī)學(xué)雜志, 2006, 86(27): 1922-1924.
25. 　Lan C, Li Y, He J, et al. Placental site trophoblastic tumor: lymphatic spread and possible target markers[J]. Gynecol Oncol, 2010, 116(3): 430-437.
26. 　Newlands ES, Mulholland PJ, Holden L, et al. Etoposide and cisplatin/etoposide, methotrexate, and actinomycin-D(EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors[J]. J Clin Oncol, 2000, 18(4): 854-859.
27. 　Nagai Y, Wakayama A, Suzuki S, et al. Metastatic placental site trophoblastic tumour successfully treated with hysterectomy and EMA/CO chemotherapy[J]. J Obstet Gynaecol, 2011, 31(1): 99-101.
28. 　Randall TC, Coukos G, Wheeler JE, et al. Prolonged Remission of Recurrent, Metastatic Placental Site Trophoblastic Tumor after Chemotherapy[J]. Gynecol Oncol, 2000, 76(1): 115-117.
  1. 1. 　Kurman RJ, Scully RE, Norris HJ. Trophoblastic psuedotumor of the uterus. An exaggerated form of “synctial endometritis” simulating a malignant tumor[J]. Cancer, 1976, 38(3): 1214-1226.
  2. 2. 　Twiggs LB, Okagaki T, Philips GL, et al. Trophoblastic pseudotumor- evidence of malignant disease potential[J]. Gynecol Oncol, 1981, 12(2 Pt 1): 238-248.
  3. 3. 　Scully RE, Young RH. Trophoblastic pseudotumor: a reappraisal[J]. Am J Surg Pathol, 981, 5(1): 75-76.
  4. 4. 　Schmid P, Nagai Y, Agarwal R, et al. Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study[J]. Lancet, 2009, 374(9683): 48-55.
  5. 5. 　石一復(fù), 李娟清, 鄭偉. 360余萬次妊娠中妊娠滋養(yǎng)細胞疾病發(fā)生情況調(diào)查[J]. 中華婦產(chǎn)科雜志, 2005, 40(2): 76-78.
  6. 6. 　趙峻, 向陽. 胎盤部位滋養(yǎng)細胞腫瘤及其診治[J]. 實用腫瘤雜志, 2008, 23(1): 5-7.
  7. 7. 　Zwischenberger BA, Boren T. Placental site trophoblastc tumor presenting as a friable mass[J]. Eur J Gynaecol Oncol, 2010, 31(5): 570-572.
  8. 8. 　Soma H, Okada T, Yoshinari T, et al. Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy[J]. J Obstet Gynaecol Res, 2004, 30(2): 113-116.
  9. 9. 　Khan S, Dancey G, Lindsay I, et al. Placental site trophoblastic tumour derived from an oocyte donation pregnancy[J]. BJOG, 2006, 113(3): 344-346.
  10. 10. 　Hui P, Wang HL, Chu P, et al. Absence of Y chromosome in human placental site trophoblastic tumor[J]. Modern Pathol, 2007, 20(10): 1055-1060.
  11. 11. 　Hui P, Parkash V, Perkins AS, et al. Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome[J]. Lab Invest, 2000, 80(6): 965-972.
  12. 12. 　Baergen RN, Rutgers JL, Young RH, et al. Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance[J]. Gynecol Oncol, 2006, 100(3): 511-520.
  13. 13. 　Feltmate CM, Genest DR, Wise L, et al. Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center[J]. Gynecol Oncol, 2001, 82(3): 415-419.
  14. 14. 　Arroyo MR, Podda A, Cao D, et al. Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty[J]. Pediatr Dev Pathol, 2009, 12(1): 73-76.
  15. 15. 　Suurmeijer AJH, Gietema JA, Hoekstra HJ. Placental Site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis[J]. Am J Surg Pathol, 2004, 28(6): 830-833.
  16. 16. 　Hassadia A, Gillespie A, Tidy J, et al. Placental site trophoblastic tumour: clinical features and management[J]. Gynecol Oncol, 2005, 99(3): 603-607.
  17. 17. 　Ajithkumar TV, Abraham EK, Rejnishkumar R, et al. Placental site trophoblastic tumor[J]. Obstet Gynecol Survey, 2003, 58(7): 484-488.
  18. 18. 　Behtash N, Zarchi MK. Placental site trophoblastic tumor[J]. J Cancer Res Clin Oncol, 2008, 134(1): 1-6.
  19. 19. 　Chang YL, Chang TC, Hsueh S, et al. Prognostic factors and treatment for placental site trophoblastic tumor- report of 3 cases and analysis of 88 cases[J]. Gynecol Oncol, 1999, 73(2): 216-222.
  20. 20. 　Guvendag GES, Guven S, Esinler I, et al. Placental site trophoblastic tumor in a patient with brain and lung metastases[J]. Int J Gynecol Cancer, 2004, 14(3): 558-563.
  21. 21. 　Cole LA, Khanlian SA, Muller CY, et al. Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free β-subunit, a reliable marker of placental site trophoblastic tumors[J]. Gynecol Oncol, 2006, 102(2): 160-164.
  22. 22. 　Sumi Y, Ozaki Y, Shindoh N, et al. Placental site trophoblastic tumor: imaging findings[J]. Radiat Med, 1999, 17(6): 427-430.
  23. 23. 　沈丹華, 廖曉耘, 劉艷麗, 等. 胎盤部位過度反應(yīng)及胎盤部位結(jié)節(jié)的臨床病理分析[J]. 中華病理學(xué)雜志, 2004, 33(5): 441-444.
  24. 24. 　趙峻, 向陽, 萬希潤, 等. 胎盤部位滋養(yǎng)細胞腫瘤的臨床病理特征及預(yù)后分析[J]. 中華醫(yī)學(xué)雜志, 2006, 86(27): 1922-1924.
  25. 25. 　Lan C, Li Y, He J, et al. Placental site trophoblastic tumor: lymphatic spread and possible target markers[J]. Gynecol Oncol, 2010, 116(3): 430-437.
  26. 26. 　Newlands ES, Mulholland PJ, Holden L, et al. Etoposide and cisplatin/etoposide, methotrexate, and actinomycin-D(EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors[J]. J Clin Oncol, 2000, 18(4): 854-859.
  27. 27. 　Nagai Y, Wakayama A, Suzuki S, et al. Metastatic placental site trophoblastic tumour successfully treated with hysterectomy and EMA/CO chemotherapy[J]. J Obstet Gynaecol, 2011, 31(1): 99-101.
  28. 28. 　Randall TC, Coukos G, Wheeler JE, et al. Prolonged Remission of Recurrent, Metastatic Placental Site Trophoblastic Tumor after Chemotherapy[J]. Gynecol Oncol, 2000, 76(1): 115-117.