• 四川大學華西醫(yī)院腫瘤中心（成都，610041）;

目的 　初步探討影響男性乳腺癌患者預后的因素?！?方法 　收集2003年1月－2011年12月經(jīng)病理確診、接受治療、臨床資料較完整的36例男性乳腺癌患者的臨床資料。采用對數(shù)秩檢驗和Cox回歸分析影響男性乳腺癌患者預后的因素。 結果 　36例患者無進展生存期（PFS）為3～95個月，中位PFS為45個月。單因素分析顯示：腫瘤直徑（P=0.001）、陽性淋巴結（P=0.001）、TNM分期（P＜0.001）、手術方式（P=0.001）是影響預后的因素。多因素分析顯示：陽性淋巴結（P=0.024）和TNM分期（P=0.022）是影響預后的主要因素。 結論 　陽性淋巴結和TNM分期是影響預后的主要因素，以手術為主的綜合治療模式是提高男性乳腺癌患者生存率的重要措施。

引用本文： 韓梅,鄭鴻,羅婷,孫愚. 男性乳腺癌預后的單中心分析. 華西醫(yī)學, 2012, 27(4): 495-500. doi: 復制

1. 　Cutuli B, Le-Nir CC, Serin D, et al. Evolution of treatment and prognostic factors. Analysis of 489 cases[J]. Crit Rev Oncol Hematol, 2010, 73(3): 246-254.
2. 　Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
3. 　Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men[J]. Ann Intern Med, 2002, 137(8): 678-687.
4. 　Donegan WL, Redlich PN. Breast cancer in men[J]. Surg Clin North Am, 1996, 76(2): 343-363.
5. 　Goss PE, Reid C, Pintilie M, et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996[J]. Cancer, 1999, 85(3): 629-639.
6. 　Malani AK. Male breast cancer: a different disease than female breast cancer[J]. South Med J, 2007, 100(2): 197.
7. 　Contractor KB, Kaur K, Rodrigues GS, et al. Male breast cancer: is the scenario changing[J]. World J Surg Oncol, 2008, 6(58): 58.
8. 　Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual[M]. 7th ed. New York: Springer, 2010: 321-325.
9. 　Speirs V, Shaaban AM. The rising incidence of male breast cancer[J]. Breast Cancer Res Treat, 2009, 115(2): 429-430.
10. 　Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
11. 　Giordano SH. A review of the diagnosis and management of male breast cancer[J]. Oncologist, 2005, 10(7): 471-479.
12. 　Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma[J]. Can J Surg, 2002, 45(4): 296-302.
13. 　Ben Dhiab T, Bouzid T, Gamoudi A, et al. Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999[J]. Bull Cancer, 2005, 92(3): 281-285.
14. 　Comet B, Cutuli B, Penault-Llorca F, et al. Male breast cancer: a review[J]. Bull Cancer, 2009, 96(2): 181-189.
15. 　Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
16. 　Yildirim E, Berbero?lu U. Male breast cancer: a 22-year experience[J]. Eur J Surg Oncol, 1998, 24(6): 548-552.
17. 　Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
18. 　Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
19. 　Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
20. 　Tarone RE, Chu KC. The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States)[J]. Cancer Causes Control, 2002, 13(1): 7-14.
21. 　Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.
  1. 1. 　Cutuli B, Le-Nir CC, Serin D, et al. Evolution of treatment and prognostic factors. Analysis of 489 cases[J]. Crit Rev Oncol Hematol, 2010, 73(3): 246-254.
  2. 2. 　Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
  3. 3. 　Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men[J]. Ann Intern Med, 2002, 137(8): 678-687.
  4. 4. 　Donegan WL, Redlich PN. Breast cancer in men[J]. Surg Clin North Am, 1996, 76(2): 343-363.
  5. 5. 　Goss PE, Reid C, Pintilie M, et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996[J]. Cancer, 1999, 85(3): 629-639.
  6. 6. 　Malani AK. Male breast cancer: a different disease than female breast cancer[J]. South Med J, 2007, 100(2): 197.
  7. 7. 　Contractor KB, Kaur K, Rodrigues GS, et al. Male breast cancer: is the scenario changing[J]. World J Surg Oncol, 2008, 6(58): 58.
  8. 8. 　Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual[M]. 7th ed. New York: Springer, 2010: 321-325.
  9. 9. 　Speirs V, Shaaban AM. The rising incidence of male breast cancer[J]. Breast Cancer Res Treat, 2009, 115(2): 429-430.
  10. 10. 　Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
  11. 11. 　Giordano SH. A review of the diagnosis and management of male breast cancer[J]. Oncologist, 2005, 10(7): 471-479.
  12. 12. 　Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma[J]. Can J Surg, 2002, 45(4): 296-302.
  13. 13. 　Ben Dhiab T, Bouzid T, Gamoudi A, et al. Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999[J]. Bull Cancer, 2005, 92(3): 281-285.
  14. 14. 　Comet B, Cutuli B, Penault-Llorca F, et al. Male breast cancer: a review[J]. Bull Cancer, 2009, 96(2): 181-189.
  15. 15. 　Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
  16. 16. 　Yildirim E, Berbero?lu U. Male breast cancer: a 22-year experience[J]. Eur J Surg Oncol, 1998, 24(6): 548-552.
  17. 17. 　Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
  18. 18. 　Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
  19. 19. 　Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
  20. 20. 　Tarone RE, Chu KC. The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States)[J]. Cancer Causes Control, 2002, 13(1): 7-14.
  21. 21. 　Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.