• 四川大學(xué)華西醫(yī)院腫瘤中心腹部腫瘤科（成都，610041）;

口腔黏膜炎是放射及化學(xué)治療常見的不良反應(yīng)，而口腔黏膜炎引起的繼發(fā)反應(yīng)，是影響患者生活質(zhì)量的重要原因，所以對于口腔黏膜炎的護(hù)理非常重要。本文對放射及化學(xué)治療引起口腔黏膜炎的護(hù)理進(jìn)行了總結(jié)，以便于臨床工作中醫(yī)護(hù)人員正確評估患者的口腔，同時能夠及時給予患者最佳的護(hù)理措施，進(jìn)而提高患者的生活質(zhì)量。

引用本文： 劉曉菊,汪秀云. 放射及化學(xué)治療所致口腔黏膜炎的護(hù)理. 華西醫(yī)學(xué), 2012, 27(6): 938-940. doi: 復(fù)制

1. 　Cawley MM, Benson LM. Current trend in managing oral mucositis clinical[J]. Clin J Oncol Nurs, 2005, 9(5): 584-592.
2. 　Wright J. Chemotherapy- induced oralmucositis: new approaches to prevention and management[J]. Expert Opin Drug Saf, 2005, 4(2): 193-200.
3. 　張文陸, 宇長青, 王言. 放化療引起的OM的病理基礎(chǔ)和診斷概況[J].醫(yī)學(xué)綜述, 2007, 13(18): 1388-1390.
4. 　陳燕芳. 放化療所致OM的護(hù)理研究現(xiàn)狀[J]. 護(hù)理實(shí)踐與研究2011, 8(3): 109-110.
5. 　Sonis ST. Oral mucositis in cancer therapy[J]. J Support Oncol, 2004, 2(Suppl 3): 3-8.
6. 　劉建紅, 鄭曉莉, 茅靜, 等.化療致OM的相關(guān)因素分析[J]. 2007, 22(17): 7-9.
7. 　Baladucci L, ExterrmanM. Management of cancer in the older person: a practical approach[J]. Oncologist, 2000, 20: 224-237.
8. 　Avritscher E, Cookley C, Elting L. Scope and epidemiology of cancer-therapy induced oral and gastrointestinalmucositis[J]. Semin Oncol Nursing, 2004, 20(1): 3-8.
9. 　Wright J, Feld R. Knox J. Chemotherapy-inducedoralmucositis new approaches to prevention and management[ J]. Exper Opin Drug Saf, 2005, 4(2): 193-200.
10. 　Quinna B, Carin M. J. Pottingb, R. Guidelines for the assessmentoforalmucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patient [J]. Eur J Cancer Care (Engl), 2008, 44: 61-72.
11. 　徐慧穎, 李亞潔, 廖曉艷. OM護(hù)理研究進(jìn)展[J]. 護(hù)理研究, 2008, 22(6): 1505-1507.
12. 　徐慧穎, 李亞潔, 廖曉艷. OM評估量表及其應(yīng)用研究[J]. 護(hù)理研究, 2008, 11(22): 2917-2918.
13. 　Eilers J. Nursing interventions and supportive care for the pre-vention and treatment of oral mucositis associated with cancer treatment[J]. 2004, 4(31): 13-23.
14. 　殷磊. 護(hù)理學(xué)基礎(chǔ)[M]. 3版. 北京: 人民衛(wèi)生出版社, 2005: 274.
15. 　朱國亞. 冰水含漱預(yù)防化療后OM的護(hù)理觀察[J]. 安徽預(yù)防醫(yī)學(xué)雜志 , 2007, 13(4): 317-318.
16. 　何為, 張玉蓮, 梅慧, 等. 復(fù)方棒冰綜合防治鼻咽癌患者放射性口腔黏膜反應(yīng)的臨床研究[J]. 中華護(hù)理雜志, 2006, 41(1): 20-23.
17. 　張玲, 閻平, 韓麗娟, 等. 低溫預(yù)防大劑量美法侖導(dǎo)致OM的臨床觀察[J]. 護(hù)理研究, 2010, 24(3B): 708-709.
18. 　常韻芳. 粒細(xì)胞集落刺激因子霧化吸入治療放射性O(shè)M的臨床觀察[J]. 中國當(dāng)代醫(yī)藥, 2009, 16(3): 94.
19. 　徐劍鴻. 頭頸部腫瘤放療中輔以霧化吸入的應(yīng)用和護(hù)理[J]. 安徽預(yù)防醫(yī)學(xué)雜志, 2006, 12(5): 346-347.
20. 　王君艷, 紀(jì)玉梅, 王佳宏. 頭頸部腫瘤放療致口腔黏膜反應(yīng)兩種治療方法比較[J]. 齊魯護(hù)理雜志, 2007, 13(17): 66.
21. 　謝松喜, 李偉雄, 陳應(yīng)瑞. 口服谷氨酰胺治療放射性O(shè)M的隨機(jī)對照研究[J]. 重慶醫(yī)學(xué), 2005, 8(34): 1195-1196.
22. 　竇慧芹，扈東艷，王秀問，等. 谷氨酰胺顆粒對化療所致OM的療效分析[J] . 山東大學(xué)學(xué)報, 2010, 48(7): 112-114.
23. 　趙建國, 張凌, 項曉軍, 等. 重組人粒細(xì)胞集落刺激因子預(yù)防放射性O(shè)M的臨床觀察[J]. 中國藥房, 2010, 48(8): 4547-4548．.
24. 　Schubert MM, Eduardo FP, Guthrie KA, et al. A phaseⅢrandomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositisin patients undergoing hematopoietic cell transplant ation[J]. Support Care Cancer, 2007, 15(10): 1145-1154.
25. 　Colella G, Cannavale R, Vicidomini A. Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial[J]. Int J Immuno pathol Pharmacol, 2010, 23(1):143-151.
26. 　Vayne-Bossert P, Escher M, de Vautibault CG. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010, 13(2): 125-128.
27. 　Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis[J]. Ann Oncol, 2007, 18(5): 817-826.
  1. 1. 　Cawley MM, Benson LM. Current trend in managing oral mucositis clinical[J]. Clin J Oncol Nurs, 2005, 9(5): 584-592.
  2. 2. 　Wright J. Chemotherapy- induced oralmucositis: new approaches to prevention and management[J]. Expert Opin Drug Saf, 2005, 4(2): 193-200.
  3. 3. 　張文陸, 宇長青, 王言. 放化療引起的OM的病理基礎(chǔ)和診斷概況[J].醫(yī)學(xué)綜述, 2007, 13(18): 1388-1390.
  4. 4. 　陳燕芳. 放化療所致OM的護(hù)理研究現(xiàn)狀[J]. 護(hù)理實(shí)踐與研究2011, 8(3): 109-110.
  5. 5. 　Sonis ST. Oral mucositis in cancer therapy[J]. J Support Oncol, 2004, 2(Suppl 3): 3-8.
  6. 6. 　劉建紅, 鄭曉莉, 茅靜, 等.化療致OM的相關(guān)因素分析[J]. 2007, 22(17): 7-9.
  7. 7. 　Baladucci L, ExterrmanM. Management of cancer in the older person: a practical approach[J]. Oncologist, 2000, 20: 224-237.
  8. 8. 　Avritscher E, Cookley C, Elting L. Scope and epidemiology of cancer-therapy induced oral and gastrointestinalmucositis[J]. Semin Oncol Nursing, 2004, 20(1): 3-8.
  9. 9. 　Wright J, Feld R. Knox J. Chemotherapy-inducedoralmucositis new approaches to prevention and management[ J]. Exper Opin Drug Saf, 2005, 4(2): 193-200.
  10. 10. 　Quinna B, Carin M. J. Pottingb, R. Guidelines for the assessmentoforalmucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patient [J]. Eur J Cancer Care (Engl), 2008, 44: 61-72.
  11. 11. 　徐慧穎, 李亞潔, 廖曉艷. OM護(hù)理研究進(jìn)展[J]. 護(hù)理研究, 2008, 22(6): 1505-1507.
  12. 12. 　徐慧穎, 李亞潔, 廖曉艷. OM評估量表及其應(yīng)用研究[J]. 護(hù)理研究, 2008, 11(22): 2917-2918.
  13. 13. 　Eilers J. Nursing interventions and supportive care for the pre-vention and treatment of oral mucositis associated with cancer treatment[J]. 2004, 4(31): 13-23.
  14. 14. 　殷磊. 護(hù)理學(xué)基礎(chǔ)[M]. 3版. 北京: 人民衛(wèi)生出版社, 2005: 274.
  15. 15. 　朱國亞. 冰水含漱預(yù)防化療后OM的護(hù)理觀察[J]. 安徽預(yù)防醫(yī)學(xué)雜志 , 2007, 13(4): 317-318.
  16. 16. 　何為, 張玉蓮, 梅慧, 等. 復(fù)方棒冰綜合防治鼻咽癌患者放射性口腔黏膜反應(yīng)的臨床研究[J]. 中華護(hù)理雜志, 2006, 41(1): 20-23.
  17. 17. 　張玲, 閻平, 韓麗娟, 等. 低溫預(yù)防大劑量美法侖導(dǎo)致OM的臨床觀察[J]. 護(hù)理研究, 2010, 24(3B): 708-709.
  18. 18. 　常韻芳. 粒細(xì)胞集落刺激因子霧化吸入治療放射性O(shè)M的臨床觀察[J]. 中國當(dāng)代醫(yī)藥, 2009, 16(3): 94.
  19. 19. 　徐劍鴻. 頭頸部腫瘤放療中輔以霧化吸入的應(yīng)用和護(hù)理[J]. 安徽預(yù)防醫(yī)學(xué)雜志, 2006, 12(5): 346-347.
  20. 20. 　王君艷, 紀(jì)玉梅, 王佳宏. 頭頸部腫瘤放療致口腔黏膜反應(yīng)兩種治療方法比較[J]. 齊魯護(hù)理雜志, 2007, 13(17): 66.
  21. 21. 　謝松喜, 李偉雄, 陳應(yīng)瑞. 口服谷氨酰胺治療放射性O(shè)M的隨機(jī)對照研究[J]. 重慶醫(yī)學(xué), 2005, 8(34): 1195-1196.
  22. 22. 　竇慧芹，扈東艷，王秀問，等. 谷氨酰胺顆粒對化療所致OM的療效分析[J] . 山東大學(xué)學(xué)報, 2010, 48(7): 112-114.
  23. 23. 　趙建國, 張凌, 項曉軍, 等. 重組人粒細(xì)胞集落刺激因子預(yù)防放射性O(shè)M的臨床觀察[J]. 中國藥房, 2010, 48(8): 4547-4548．.
  24. 24. 　Schubert MM, Eduardo FP, Guthrie KA, et al. A phaseⅢrandomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositisin patients undergoing hematopoietic cell transplant ation[J]. Support Care Cancer, 2007, 15(10): 1145-1154.
  25. 25. 　Colella G, Cannavale R, Vicidomini A. Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial[J]. Int J Immuno pathol Pharmacol, 2010, 23(1):143-151.
  26. 26. 　Vayne-Bossert P, Escher M, de Vautibault CG. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010, 13(2): 125-128.
  27. 27. 　Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis[J]. Ann Oncol, 2007, 18(5): 817-826.