【摘要】 目的 探討成都市成華區(qū)中老年人群血脂水平、分布特點(diǎn)及其與胰島素抵抗指數(shù)（HOMA-IR）的關(guān)系。 方法 2007年5月在此區(qū)中老年（50~79歲）人群中隨機(jī)抽取672人進(jìn)行心血管危險(xiǎn)因素研究調(diào)查，對(duì)其血脂水平及HOMA-IR進(jìn)行統(tǒng)計(jì)分析。 結(jié)果 人群當(dāng)中①女性各血脂項(xiàng)目的水平均比男性高，其中總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）的差異有統(tǒng)計(jì)學(xué)意義（P lt;0.05）；②三酰甘油（TG）升高的比例較高，其中男性為30.0%，女性為27.6%；大部分人群HDL-C、低密度脂蛋白膽固醇（LDL-C）水平處于合適范圍，HDL-C降低的比例為6.0%，LDL-C升高的比例為7.3%；③隨著TG水平的升高、HDL-C 水平的降低，HOMA-IR呈升高趨勢(shì)；LDL-C水平的升高，HOMA-IR呈升高趨勢(shì)，僅在女性人群中差異有統(tǒng)計(jì)學(xué)意義（P lt;0.05），在男性人群中差異無(wú)統(tǒng)計(jì)學(xué)意義；④TG與HOMA-IR呈正相關(guān)，相關(guān)系數(shù)為0.185（P=0.000）；HDL-C與HOMA-IR呈負(fù)相關(guān)，相關(guān)系數(shù)為-0.145（P=0.000）。LDL-C與HOMA-IR呈正相關(guān)，相關(guān)系數(shù)為0.099（P=0.010）。 結(jié)論 TG增高是成都市成華區(qū)中老年人群的顯著特點(diǎn)，女性HDL-C比男性高；血脂紊亂與胰島素抵抗相關(guān)。
【Abstract】 Objective To investigate the relationship between blood lipids level and homeostasis model assessment-insulin resistance (HOMA-IR) in elder people in Chengdu. Methods In May 2007, 672 people aged from 50 to 79 years in Chengdu were recruited by random sampling methods for the survey of cardiovascular risk factors. The blood lipids level and HOMA-IR were statistically analyzed. Results ① The serum total cholesterol (TC) and high density lipoprotein chole sterol (HDL-C) were obviously higher in women than those in men (P lt;0.05). ② Triacylglycerol (TG) increased in 30.0% of men and 27.6% of women; HDL-C and low density lipoprotein cholesterin (LDL-C) in most of the involved people were appropriate. ③ HOMA-IR increased as the TG level increased and HDL-C decreased; HOMA-IR increased as the LDL-C level increased, which was significant in the females (P lt;0.05). ④ HDL-C was positively correlated with HOMA-IR (r=-0.145, P=0.000); LDL-C was positively correlated with HOMA-IR (r=0.099, P=0.010). Conclusion The increase of hypertriglyceridemia was the most frequent type of the dislipidemia in the elder people in Chengdu; HDL-C level is higher in women than in men. Dyslipidemia is correlated with insulin resistance.
引用本文： 陳小妮,陳曉平,吳凱,王斯,李龍心,萬(wàn)里艷. 成都市成華區(qū)中老年人群血脂水平及其與胰島素抵抗指數(shù)的關(guān)系. 華西醫(yī)學(xué), 2011, 26(3): 328-330. doi: 復(fù)制
| 1. | World Health Organization. Multinational monitoring of trends and determinants in cardiovascular diseases MONICA Project and manual of operation[Z]. Cardiovascular Disease Unit, 1983. |
| 2. | 中國(guó)成人血脂異常防治指南制訂聯(lián)合委員會(huì). 中國(guó)成人血脂異常防治指南[M]. 北京: 人民衛(wèi)生出版社, 2007: 7-8. |
| 3. | 中華醫(yī)學(xué)會(huì)糖尿病學(xué)分會(huì)代謝綜合征研究協(xié)助組. 中華醫(yī)學(xué)會(huì)糖尿病學(xué)分會(huì)關(guān)于代謝綜合征的建議[J]. 中華糖尿病雜志, 2004, 12(3): 156. |
| 4. | Alberti KG, Zimmet P, Shaw J, et al. The metabolic syndrome-a new worldwide definition[J]. Lancet, 2005, 366(9491): 1059-1062. |
| 5. | 武陽(yáng)豐, 趙冬, 周北凡, 等. 中國(guó)成人血脂異常診斷和危險(xiǎn)分層方案的研究[J]. 中華心血管病雜志, 2007, 35(5): 428-433. |
| 6. | 王薇, 趙冬, 吳兆蘇, 等. 中國(guó)11省市35～64歲人群甘油三酯分布特點(diǎn)及與其他心血管危險(xiǎn)因素關(guān)系的研究[J]. 中華流行病學(xué)雜志, 2001, 22(1): 26-29. |
| 7. | American Diabetes Association. Consensus development conference on insulin resistance[J]. Diabetes Care, 1998, 21(2): 310-314. |
| 8. | Stern MP. Diabetes and cardiovascular disease: The “Common soil” hypothesis[J]. Diabetes, 1995, 44(4): 369-374. |
| 9. | 中國(guó)高血壓防治指南修訂委員會(huì). 中國(guó)高血壓防治指南(2005年修訂版)[J]. 高血壓雜志, 2005, 134(增刊): 2-41. |
| 10. | Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia, 1985, 28(7): 412-419. |
| 11. | Haffner SM, Kennedy E, Gonzalez C, et al. A prospective analysis of the HOMA model: the Mexico City Diabetes Study[J]. Diabetes Care, 1996, 19(10): 1138-1141. |
| 12. | Boden G. Interaction between free fatty acids and glucose metabolism[J]. Curr Opin Clin Nutr Metab Care, 2002, 5(5): 545-549. |
- 1. World Health Organization. Multinational monitoring of trends and determinants in cardiovascular diseases MONICA Project and manual of operation[Z]. Cardiovascular Disease Unit, 1983.
- 2. 中國(guó)成人血脂異常防治指南制訂聯(lián)合委員會(huì). 中國(guó)成人血脂異常防治指南[M]. 北京: 人民衛(wèi)生出版社, 2007: 7-8.
- 3. 中華醫(yī)學(xué)會(huì)糖尿病學(xué)分會(huì)代謝綜合征研究協(xié)助組. 中華醫(yī)學(xué)會(huì)糖尿病學(xué)分會(huì)關(guān)于代謝綜合征的建議[J]. 中華糖尿病雜志, 2004, 12(3): 156.
- 4. Alberti KG, Zimmet P, Shaw J, et al. The metabolic syndrome-a new worldwide definition[J]. Lancet, 2005, 366(9491): 1059-1062.
- 5. 武陽(yáng)豐, 趙冬, 周北凡, 等. 中國(guó)成人血脂異常診斷和危險(xiǎn)分層方案的研究[J]. 中華心血管病雜志, 2007, 35(5): 428-433.
- 6. 王薇, 趙冬, 吳兆蘇, 等. 中國(guó)11省市35～64歲人群甘油三酯分布特點(diǎn)及與其他心血管危險(xiǎn)因素關(guān)系的研究[J]. 中華流行病學(xué)雜志, 2001, 22(1): 26-29.
- 7. American Diabetes Association. Consensus development conference on insulin resistance[J]. Diabetes Care, 1998, 21(2): 310-314.
- 8. Stern MP. Diabetes and cardiovascular disease: The “Common soil” hypothesis[J]. Diabetes, 1995, 44(4): 369-374.
- 9. 中國(guó)高血壓防治指南修訂委員會(huì). 中國(guó)高血壓防治指南(2005年修訂版)[J]. 高血壓雜志, 2005, 134(增刊): 2-41.
- 10. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia, 1985, 28(7): 412-419.
- 11. Haffner SM, Kennedy E, Gonzalez C, et al. A prospective analysis of the HOMA model: the Mexico City Diabetes Study[J]. Diabetes Care, 1996, 19(10): 1138-1141.
- 12. Boden G. Interaction between free fatty acids and glucose metabolism[J]. Curr Opin Clin Nutr Metab Care, 2002, 5(5): 545-549.