• 1 成都市第三人民醫(yī)院神經(jīng)內(nèi)科（成都，610031）; 2 重慶醫(yī)科大學(xué)附屬第二醫(yī)院神經(jīng)內(nèi)科;

【摘要】　目的　 探討急性腦梗死對(duì)心臟自主神經(jīng)活性的影響。　方法　 Wistar大鼠32只隨機(jī)分為正常組、假手術(shù)組和腦梗死組，腦梗死組用線栓法行右側(cè)大腦中動(dòng)脈阻塞。腦梗死組和假手術(shù)組于術(shù)前及術(shù)后24 h作心率變異性（HRV）檢測(cè)，同時(shí)檢測(cè)正常組HRV，將3組的HRV指標(biāo)進(jìn)行比較。實(shí)驗(yàn)終點(diǎn)取各組心肌組織檢測(cè)兒茶酚胺和神經(jīng)肽Y（NPY），進(jìn)行組間比較。　結(jié)果　 術(shù)后24 h腦梗死組和正常組、假手術(shù)組相比，竇性心搏間期標(biāo)準(zhǔn)差、均方根，總功率譜、高頻功率譜（HF）、低頻功率譜（LF）降低，差異有統(tǒng)計(jì)學(xué)意義。3組比較LF/HF和分?jǐn)?shù)維無(wú)明顯差異。腦梗死組心肌組織去甲腎上腺素（NA）和NPY高于正常組和假手術(shù)組。　結(jié)論　 腦梗死引起心臟自主神經(jīng)總活性降低、自主神經(jīng)功能受損，自主神經(jīng)末梢去甲腎上腺素和NPY的異常分泌可能是重要的原因。
【Abstract】　Objective　 To investigate the effect of acute cerebral infarction on cardiac autonomic nervous activity.　Methods　 A total of 32 Wistar rats were divided into normal group, sham operation group and infarction group by random. Experimental cerebral infarction in Wistar rats was induced by intraluminal occlusion of middle cerebral artery. About 24 hours after the occlusion or 24 hours after sham operation, the heart rate variability (HRV) sequences were measured, and the HRV values in the three groups were compared. The levels of catecholamine and neuropeptide (NPY) in myocardium were measured.　Results　 At the 24th hour after the occlusion, the standard deviation and root mean square standard deviation of R-R interval, the total power, high frequency (HF) and low frequency (LF) in infarction group were lower than those in normal and sham operation group. LF/HF and fractal dimension did not differ much among the three groups. The levels of noradrenaline and NPY in myocardium in infarction group were higher than those in the other groups.　Conclusion　 It is suggested that acute cerebral infarction may cause the decrease of autonomic nervous activity and damage of the autonomic nervous function; the abnormal secretion of noradrenalin in autonomic nerve ending and NPY may be the important reasons.

引用本文： 王蕾,李長(zhǎng)清,胡長(zhǎng)林. 實(shí)驗(yàn)性腦梗死對(duì)大鼠心率變異性的影響. 華西醫(yī)學(xué), 2011, 26(3): 344-346. doi: 復(fù)制

1. 　李長(zhǎng)清, 董為偉. 急性腦梗死患者的動(dòng)態(tài)心電圖異常[J]. 中華內(nèi)科雜志, 1999, 38(4): 239-241.
2. 　李長(zhǎng)清, 董為偉. 腦梗死患者的心電圖異常與血漿肌酸激酶-同工酶活性變化[J]. 臨床心血管病雜志, 2001, 17(11): 515-517.
3. 　李長(zhǎng)清, 董為偉, 胡長(zhǎng)林. 不同部位腦梗死患者心率變異性與血漿肌酸激酶同工酶活性變化[J]. 中華老年心腦血管病雜志, 2004, 6(4): 247-249.
4. 　Póvoa R, Cavichio L, Almeida AL, et al. Electrocardiographic abnormalities in neurological diseases[J]. Arq Bras Cardiol, 2003, 80(4): 351-358.
5. 　Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989, 20(1): 84-91.
6. 　陳運(yùn)貞, 雷寒. 檢測(cè)心臟植物神經(jīng)活性的定量方法: 心率功率分析[J]. 中華心血管病雜志, 1992, 20(2): 101-103.
7. 　王蕾, 李長(zhǎng)清, 胡長(zhǎng)林. 腦卒中并發(fā)心臟損害的實(shí)驗(yàn)研究[J]. 重慶醫(yī)學(xué), 2008, 37(6): 626-627.
8. 　Drislane FW, Samuels MA, Kozakewich H, et al. Myocardial cont raction band lesion in patients with fatal asthema: possible neurocardiologic mechanisms[J]. Am Rev Respir Dis, 1987, 135(2): 498-501.
9. 　Cheung RT, Hachinski V. The insula and cerebrogenic sudden death[J]. Arch Neurol, 2000, 57(12): 1685-1688.
10. 　蔡紫峰, 雷霆, 金英雄, 等. 大鼠局灶性腦缺血對(duì)自主神經(jīng)系統(tǒng)的影響[J]. 天津醫(yī)藥, 2006, 34(2): 101-104.
11. 　張翼, 周兆年. 神經(jīng)肽Y對(duì)心臟的作用[J]. 生命科學(xué), 1998, 10(5): 218-221.
12. 　Pedrazzini T, Pralong F, Grouzmann E. et al. Neuropeptide Y: the universal soldier[J]. Cell Mol Life Sci, 2003, 60(2): 350-377.
  1. 1. 　李長(zhǎng)清, 董為偉. 急性腦梗死患者的動(dòng)態(tài)心電圖異常[J]. 中華內(nèi)科雜志, 1999, 38(4): 239-241.
  2. 2. 　李長(zhǎng)清, 董為偉. 腦梗死患者的心電圖異常與血漿肌酸激酶-同工酶活性變化[J]. 臨床心血管病雜志, 2001, 17(11): 515-517.
  3. 3. 　李長(zhǎng)清, 董為偉, 胡長(zhǎng)林. 不同部位腦梗死患者心率變異性與血漿肌酸激酶同工酶活性變化[J]. 中華老年心腦血管病雜志, 2004, 6(4): 247-249.
  4. 4. 　Póvoa R, Cavichio L, Almeida AL, et al. Electrocardiographic abnormalities in neurological diseases[J]. Arq Bras Cardiol, 2003, 80(4): 351-358.
  5. 5. 　Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989, 20(1): 84-91.
  6. 6. 　陳運(yùn)貞, 雷寒. 檢測(cè)心臟植物神經(jīng)活性的定量方法: 心率功率分析[J]. 中華心血管病雜志, 1992, 20(2): 101-103.
  7. 7. 　王蕾, 李長(zhǎng)清, 胡長(zhǎng)林. 腦卒中并發(fā)心臟損害的實(shí)驗(yàn)研究[J]. 重慶醫(yī)學(xué), 2008, 37(6): 626-627.
  8. 8. 　Drislane FW, Samuels MA, Kozakewich H, et al. Myocardial cont raction band lesion in patients with fatal asthema: possible neurocardiologic mechanisms[J]. Am Rev Respir Dis, 1987, 135(2): 498-501.
  9. 9. 　Cheung RT, Hachinski V. The insula and cerebrogenic sudden death[J]. Arch Neurol, 2000, 57(12): 1685-1688.
  10. 10. 　蔡紫峰, 雷霆, 金英雄, 等. 大鼠局灶性腦缺血對(duì)自主神經(jīng)系統(tǒng)的影響[J]. 天津醫(yī)藥, 2006, 34(2): 101-104.
  11. 11. 　張翼, 周兆年. 神經(jīng)肽Y對(duì)心臟的作用[J]. 生命科學(xué), 1998, 10(5): 218-221.
  12. 12. 　Pedrazzini T, Pralong F, Grouzmann E. et al. Neuropeptide Y: the universal soldier[J]. Cell Mol Life Sci, 2003, 60(2): 350-377.