【摘要】 目的 觀察利膽清微丸治療慢性膽囊炎濕熱蘊(yùn)結(jié)兼血瘀證患者的療效及安全性，進(jìn)一步為臨床研究提供依據(jù)。 方法 2001年4—7月，采用雙盲、雙模擬、隨機(jī)平行對(duì)照臨床試驗(yàn)，將40例患者隨機(jī)分為試驗(yàn)組（20例）及對(duì)照組（20例）。試驗(yàn)組服用利膽清微丸3.5 g/次，3次/d，同時(shí)服用膽寧片模擬劑；對(duì)照組服用膽寧片3片/次，3次/d，同時(shí)服用利膽清微丸模擬劑。 結(jié)果 試驗(yàn)組痊愈1例，顯效12例，有效5例，無(wú)效2例，顯效率65%，有效率90%；對(duì)照組痊愈2例，顯效10例，有效7例，無(wú)效1例，顯效率60%，有效率95%，兩組療效比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P gt;0.05）。試驗(yàn)過(guò)程中未發(fā)現(xiàn)明顯不良反應(yīng)。 結(jié)論 利膽清微丸對(duì)于治療慢性膽囊炎濕熱蘊(yùn)結(jié)兼血瘀證有良好效果，是一種安全有效的藥物。
【Abstract】 Objective To observe the safety and efficacy of Lidanqing pellet on chronic cholecystitis with damp and hot accumulate knot including blood stasis, and to provide a basis for further clinical trials. Methods A double-blind, double dummy, randomized, and controlled clinic trial was undertaken between April and July 2001. A total of 40 patients were randomly divided into trail group and control group. The trial group was given Lidanqin pellet 3.5 g per time, and three times per day; simultaneously taking Danning tablet simulation agent. The control group was given 3 tablets of Danning tablet per time and three times per day; simultaneously taking taking Lidanqing pellets simulation agent. Results In the trail group, one patient was cured, the therapeutic effect was obvious in 12, basically effective in five and invalid in two (with the rate of obvious effect of 65.00% and rate of basic effect of 90.00%). In the control group, two patients was cured, the therapeutic effect was obvious in 12, basically effective in 10, effective in seven and invalid in one (with the rate of basic effect of 60.00% and the rate of obvious effect of 95.00%). The difference between the two groups was significant (P gt;0.05). Adverse reaction was not found in the trial group. Conclusion Lidanqing pellet, a safe medication, is effective on chronic cholecystitis with damp and hot accumulate knot including blood stasis.
引用本文： 白璐,陳光遠(yuǎn),張瑞明,李廷謙,王蕾,常靜,張穎,唐文富,馬建昕. 利膽清微丸治療慢性膽囊炎濕熱蘊(yùn)結(jié)兼血瘀證臨床研究. 華西醫(yī)學(xué), 2011, 26(5): 667-670. doi: 復(fù)制
| 1. | 中華人民共和國(guó)衛(wèi)生部. 中藥新藥臨床研究指導(dǎo)原則(第1輯)[S]. 1993:134-135. |
| 2. | 程堅(jiān), 上官秀珍. 慢性膽囊炎的B超影像改變[J]. 醫(yī)學(xué)理論與實(shí)踐, 2005, 18(3): 328. |
| 3. | 朱培庭, 朱世敏. 實(shí)用中醫(yī)膽病學(xué)[ M]. 北京: 人民衛(wèi)生出版社, 1999: 272. |
| 4. | 吳在德. 外科學(xué)[ M] . 北京: 人民衛(wèi)生出版社, 2002: 626-627. |
| 5. | Brugge WR, Brand DL, Atkins HL. Gallbladder dyskinesia in chronic acalculous cholecystitis[J]. Digest Dis Sci, 1986, 31(5): 461-467. |
| 6. | Schirmer BD, Winters KL, Edich RF. Cholelithiasis and cholecystitis[J]. J Long Term Med Impitants, 2005, 15(3): 329-338. |
| 7. | 秦雙件. 柴胡疏肝散合茵陳蒿湯化裁治療慢性膽囊炎濕熱血瘀證45例臨床觀察[J]. 中醫(yī)藥導(dǎo)報(bào), 2009, 15(5): 33-34. |
| 8. | 趙偉. 中西結(jié)合治療慢性膽囊炎100例療效觀察[J]. 中國(guó)醫(yī)藥指南, 2010, 8(15): 117-118. |
| 9. | 周仲英. 中醫(yī)內(nèi)科學(xué)[ M]. 北京: 中國(guó)中醫(yī)藥出版社, 2003:270-277. |
| 10. | 甄丙社. 辨證分型治療慢性膽囊炎180 例療效觀察[J]. 河北中醫(yī), 2001, 23(9): 669-670. |
| 11. | 丁彩霞, 顧勤. 慢性膽囊炎的中醫(yī)治療概述[J]. 遼寧中醫(yī)藥大學(xué)學(xué)報(bào), 2008, 10(1): 61-63. |
| 12. | 黃東源. 健脾利膽湯配合針灸治療慢性膽囊炎42例[J]. 中醫(yī)藥臨床雜志, 2005, 17(5): 481. |
| 13. | 李守恭. 自擬疏肝利膽湯治療慢性膽囊炎104例療效觀察[J]. 中國(guó)臨床醫(yī)生, 2011, 39(2): 43-44. |
| 14. | 上海中醫(yī)學(xué)院附屬龍華醫(yī)院. 黃文東醫(yī)案[M] . 上海: 上海人民出版社, 1977: 150. |
| 15. | 孫為民. 膽寧片治療慢性膽囊炎(氣郁濕熱型)90例臨床觀察[J]. 河北中醫(yī), 2002, 24(5): 382-383. |
| 16. | 石建麗, 周金寶. 膽寧片治療慢性膽囊炎45例[J]. 浙江中醫(yī)雜志, 2010, 45(3): 191. |
- 1. 中華人民共和國(guó)衛(wèi)生部. 中藥新藥臨床研究指導(dǎo)原則(第1輯)[S]. 1993:134-135.
- 2. 程堅(jiān), 上官秀珍. 慢性膽囊炎的B超影像改變[J]. 醫(yī)學(xué)理論與實(shí)踐, 2005, 18(3): 328.
- 3. 朱培庭, 朱世敏. 實(shí)用中醫(yī)膽病學(xué)[ M]. 北京: 人民衛(wèi)生出版社, 1999: 272.
- 4. 吳在德. 外科學(xué)[ M] . 北京: 人民衛(wèi)生出版社, 2002: 626-627.
- 5. Brugge WR, Brand DL, Atkins HL. Gallbladder dyskinesia in chronic acalculous cholecystitis[J]. Digest Dis Sci, 1986, 31(5): 461-467.
- 6. Schirmer BD, Winters KL, Edich RF. Cholelithiasis and cholecystitis[J]. J Long Term Med Impitants, 2005, 15(3): 329-338.
- 7. 秦雙件. 柴胡疏肝散合茵陳蒿湯化裁治療慢性膽囊炎濕熱血瘀證45例臨床觀察[J]. 中醫(yī)藥導(dǎo)報(bào), 2009, 15(5): 33-34.
- 8. 趙偉. 中西結(jié)合治療慢性膽囊炎100例療效觀察[J]. 中國(guó)醫(yī)藥指南, 2010, 8(15): 117-118.
- 9. 周仲英. 中醫(yī)內(nèi)科學(xué)[ M]. 北京: 中國(guó)中醫(yī)藥出版社, 2003:270-277.
- 10. 甄丙社. 辨證分型治療慢性膽囊炎180 例療效觀察[J]. 河北中醫(yī), 2001, 23(9): 669-670.
- 11. 丁彩霞, 顧勤. 慢性膽囊炎的中醫(yī)治療概述[J]. 遼寧中醫(yī)藥大學(xué)學(xué)報(bào), 2008, 10(1): 61-63.
- 12. 黃東源. 健脾利膽湯配合針灸治療慢性膽囊炎42例[J]. 中醫(yī)藥臨床雜志, 2005, 17(5): 481.
- 13. 李守恭. 自擬疏肝利膽湯治療慢性膽囊炎104例療效觀察[J]. 中國(guó)臨床醫(yī)生, 2011, 39(2): 43-44.
- 14. 上海中醫(yī)學(xué)院附屬龍華醫(yī)院. 黃文東醫(yī)案[M] . 上海: 上海人民出版社, 1977: 150.
- 15. 孫為民. 膽寧片治療慢性膽囊炎(氣郁濕熱型)90例臨床觀察[J]. 河北中醫(yī), 2002, 24(5): 382-383.
- 16. 石建麗, 周金寶. 膽寧片治療慢性膽囊炎45例[J]. 浙江中醫(yī)雜志, 2010, 45(3): 191.