【摘要】 目的 探討降高血壓藥物聯(lián)合抗焦慮抑郁藥物萬拉法新治療老年性原發(fā)高血壓伴焦慮抑郁障礙的療效及安全性。 方法 納入2006年10月-2008年10月我院門診和住院診治的老年性原發(fā)高血壓伴焦慮抑郁障礙患者100例,隨機(jī)分為干預(yù)組和對(duì)照組。所有患者給予常規(guī)降壓藥物治療,干預(yù)組另外給予萬拉法新治療,治療12周后評(píng)價(jià)臨床療效。結(jié)果 干預(yù)組臨床降壓療效總有效率940%,顯著高于對(duì)照組總有效率800%(P lt;005)。兩組患者的收縮壓、舒張壓與治療前比較均顯著改善(P lt;005),干預(yù)組患者與對(duì)照組比較血壓明顯改善(P lt;005)。干預(yù)組臨床抗焦慮抑郁療效總有效率960%,顯著高于對(duì)照組總有效率580%(P lt;005)。兩組均無明顯的不良反應(yīng)。結(jié)論 降高血壓藥物聯(lián)合抗焦慮抑郁藥物萬拉法新治療老年性原發(fā)高血壓伴焦慮抑郁障礙療效肯定,且安全可靠,值得臨床推廣應(yīng)用。
【Abstract】 Objective To investigate the efficacy and safety of antihypertensive drugs combined with antianxiety depression drug venlafaxine for treatment of patients with senile primary hypertension (SPH) and anxietydepression disorder (AD). Methods One hundred SPH patients with AD with were randomly divided into an intervention group and a control group. All cases were given antihypertensive drugs medication,while the intervention group was given venlafaxine. After 12 weeks of treatment,the clinical efficacy was evaluated. Results The antihypertensive efficacy rate in the intervention group was 940%,significantly higher than that of the control group 800% (P lt;005). The systolic blood pressure(SBP)and diastolic blood pressure (DBP) of the two groups significantly improved compared with those before treatment (P lt;005), and the intervention group’ SBP and DBP improved significantly than those of the control group (P lt;005). The total effective rate of antianxiety depression efficacy of the intervention group was 960%, significantly higher than that of the control group 580% (P lt;005). The two groups had no significant adverse reactions. Conclusion For patients with senile primary hypertension and anxietydepression disorder,the combination medication with antihypertensive drugs and venlafaxine was safe,reliable and worthy of clinical application.

引用本文： 楊青云,段新. 降高血壓藥物聯(lián)合萬拉法新治療老年性原發(fā)高血壓伴焦慮抑郁障礙的臨床研究. 華西醫(yī)學(xué), 2010, 25(4): 670-. doi: 復(fù)制

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