【摘要】 目的 觀察聚明膠肽注射液和羥乙基淀粉（130/0.4）氯化鈉注射液對(duì)創(chuàng)傷失血性休克患者的臨床治療效果。 方法 將2006年6月-2008年10月創(chuàng)傷失血性休克患者32例隨機(jī)分為聚明膠肽組和羥乙基淀粉組，每組16例。搶救時(shí)除采用止血、擴(kuò)容、糾酸等綜合措施外，分別輸入聚明膠肽注射液和羥乙基淀粉（130/0.4）氯化鈉注射液1 500 mL。兩組均監(jiān)測血壓、尿量和血?dú)夥治鲋笜?biāo)，比較兩組指標(biāo)恢復(fù)正常以及所需的時(shí)間。 結(jié)果 聚明膠肽組與羥乙基淀粉組上述指標(biāo)恢復(fù)正常及所需的時(shí)間無差異，兩組生存率、致殘率及并發(fā)癥均無差異。 結(jié)論 聚明膠肽注射液用于創(chuàng)傷失血性休克的療效與羥乙基淀粉（130/0.4）氯化鈉注射液相當(dāng)。
【Abstract】 Objective To observe the clinical effects of polygeline injection and hydroxyethyl starch(130/0.4) NaCl injection (HES)on the traumatic hemorrhagic shock. Methods A total of 32 patients with traumatic hemorrhagic shock were randomly divided into polygeline injection group and HES group,with 16 patients in each. The same measures such as hemstasis, expanding blood volume, correction of acid base disturbance and so on were adopted in the both groups. The patients in the polygeline injection group and HES group were respectively treated with polygeline injection and HES NaCl injection in a dose of 1500 mL by intravenous infusion. The time from injection to the recovery of BP, urinary output, and blood gas to normal level was recorded. Results BP, urinary output, and blood gas were all improved significantly, there was no significant difference between the two groups (P gt;0.05). Conclusion The clinical effect of polygeline injection on stabilizing BP and improving microcirculation appears comparable to that of HES.
引用本文： 李晉波,李璐,左可見. 聚明膠肽與羥乙基淀粉在創(chuàng)傷失血性休克中的應(yīng)用比較. 華西醫(yī)學(xué), 2010, 25(8): 1415-1417. doi: 復(fù)制
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