• 1 樂山市人民醫(yī)院麻醉科（四川樂山，614000）;2 四川省醫(yī)學(xué)科學(xué)院 四川省人民醫(yī)院麻醉科;

【摘要】 目的  比較利多卡因不同劑量預(yù)處理對羅庫溴銨注射痛的影響。 方法  120例行全身麻醉擇期手術(shù)的患者按照完全隨機(jī)的方法分為利多卡因10 mg 3 mL預(yù)處理組（A組），利多卡因25 mg 3 mL預(yù)處理組（B組），利多卡因50 mg 3 mL預(yù)處理組（C組），生理鹽水3 mL預(yù)處理組（D組）。觀察不同劑量的利多卡因預(yù)處理對羅庫溴銨注射痛的影響。 結(jié)果  A、B、C和D組注射羅庫溴銨的疼痛發(fā)生率分別為53%、27%、3%和90%。與生理鹽水預(yù)處理組相比，利多卡因預(yù)處理組能明顯減輕羅庫溴銨引起的注射痛（P lt;0.01）；劑量越大，效果越明顯。 結(jié)論  利多卡因10、25、50 mg預(yù)處理均能顯著降低羅庫溴銨注射時(shí)引起的疼痛，以50 mg利多卡因更為有效。
【Abstract】 Objective  To compare the effects of different doses of lidocaine pretreatment on the pain from injection with rocuronium. Methods  One hundred and twenty patients of general anesthesia had undergone elective surgery, were randomly divided into lidocaine 10 mg 3 mL pretreated group (group A), lidocaine 25 mg 3 mL pretreated group (group B), lidocaine 50 mg 3 mL pretreated group (group C) and saline 3 mL pretreated group (group D). The effects of different doses of lidocaine pretreatment on injection pain of rocuronium were observed. Results  The pain incidence from injection with rocuronium in A, B, C, D groups were 53%, 27%, 3% and 90% respectively. The higher dose of lidocaine, the more obvious effect. Conclusion  Lidocaine pretreatment with 10, 25, 50 mg can reduce the severity of pain from injection with rocuronium, and lidocaine 50 mg is the most effective.

引用本文： 曾洪友,曾思. 不同劑量利多卡因預(yù)處理對羅庫溴銨注射痛的影響. 華西醫(yī)學(xué), 2010, 25(8): 1527-1529. doi: 復(fù)制

1. Silverman DG. Neuromuscular block in perioperative and intensive care[M]. Philadelphia: J. B. Lippincott, 1994: 204-210.
2. Borgeat A, Kwiatkowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause?[J] Br J Anaesth, 1997, 79(3): 382-383.
3. Shevchenko Y, Jocson JC, McRae VA, et al. The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents[J]. Anesth Analg, 1999, 88(4): 746-748.
4. Memis D, Turan A, Karamanliogly B, et al. The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl[J]. Anesth Analg, 2002, 94(6): 1517-1520.
5. Turan A, Memis D, Karamanlioglu B, et al. The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil[J]. Anaesth Intensive Care, 2003, 31(3): 277-281.
6. Chiarella AB, Jolly DT, Huston CM, et al. Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium[J]. Br J Anaesth, 2003, 90(3): 377-379.
7. Klement W, Arndt JO, Pain on IV. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations[J]. Br J Anaesth 1991, 66(2): 189-195.
8. Lockey D, Coleman P. Pain during injection of rocuronium bromide[J]. Anaesthesia 1995, 50(5): 474.
9. Lee HJ, Han SJ, Kim H, et al. Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection[J]. J Korean Med Sci, 2009, 24(5): 879-882.
10. Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment[J]. Br J Anaesth 2000, 84(1): 106-107.
  1. 1. Silverman DG. Neuromuscular block in perioperative and intensive care[M]. Philadelphia: J. B. Lippincott, 1994: 204-210.
  2. 2. Borgeat A, Kwiatkowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause?[J] Br J Anaesth, 1997, 79(3): 382-383.
  3. 3. Shevchenko Y, Jocson JC, McRae VA, et al. The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents[J]. Anesth Analg, 1999, 88(4): 746-748.
  4. 4. Memis D, Turan A, Karamanliogly B, et al. The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl[J]. Anesth Analg, 2002, 94(6): 1517-1520.
  5. 5. Turan A, Memis D, Karamanlioglu B, et al. The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil[J]. Anaesth Intensive Care, 2003, 31(3): 277-281.
  6. 6. Chiarella AB, Jolly DT, Huston CM, et al. Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium[J]. Br J Anaesth, 2003, 90(3): 377-379.
  7. 7. Klement W, Arndt JO, Pain on IV. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations[J]. Br J Anaesth 1991, 66(2): 189-195.
  8. 8. Lockey D, Coleman P. Pain during injection of rocuronium bromide[J]. Anaesthesia 1995, 50(5): 474.
  9. 9. Lee HJ, Han SJ, Kim H, et al. Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection[J]. J Korean Med Sci, 2009, 24(5): 879-882.
  10. 10. Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment[J]. Br J Anaesth 2000, 84(1): 106-107.