• 1 宜賓市第一人民醫(yī)院消化內(nèi)科（四川宜賓，644000）;2 瀘州醫(yī)學(xué)院附屬醫(yī)院;3 四川省宜賓衛(wèi)生學(xué)校;

【摘要】 目的  探討益生菌治療在潰瘍性結(jié)腸炎（ulcerative colitis，UC）患者中的臨床應(yīng)用效果。 方法  選取2007年8月-2009年12月47例活動期UC患者，隨機分為治療組和對照組，分別給予益生菌和5-氨基水楊酸治療，療程8周。監(jiān)測治療期間患者的臨床癥狀和血清C反應(yīng)蛋白（Creactive protein，CRP）水平。 結(jié)果  治療結(jié)束后兩組患者臨床癥狀均有緩解，CRP水平均明顯下降，兩組間無統(tǒng)計學(xué)意義（P gt;0.05）。 結(jié)論  益生菌治療UC可有效改善患者臨床癥狀和炎癥反應(yīng)。

引用本文： 張淑平,代嘉莉,代加平. 益生菌治療在潰瘍性結(jié)腸炎中的臨床應(yīng)用. 華西醫(yī)學(xué), 2010, 25(9): 1713-1714. doi: 復(fù)制

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  3. 3. Masseret E, Boudeau J, Colombel JF, et al. Genetically related Escherichia coli strains associated with Crohn′s disease [J]. Gut, 2001, 48(3): 320-325.
  4. 4. Fabia R, Ar′Rajab A, Johansson ML, et al. Impairment of bacterial flora in human ulcerative colitis and experimental colitis in the rat [J]. Digestion, 1993, 54(4): 248-255.
  5. 5. Laudanno OM, Cesolari JA, Godoy A, et al. Bioflora probiotic in immunomodulation and prophylaxis of intestinal bacterial translocation in rats[J]. Dig Dis Sci, 2008, 53(10): 2667-2670.
  6. 6. Schiffrin EJ, Blum S. Interactions between the microbiota and the intestinal mucosa [J]. Eur J Clin Nutr, 2002, 56(Suppl 3): 60-64.