邱里 1 , 何慶 2
  • 1 川北醫(yī)學(xué)院附屬醫(yī)院急診科（四川南充，637000）;2 四川大學(xué)華西醫(yī)院急診科;

【摘要】 目的  探討細(xì)菌性膠原酶對(duì)創(chuàng)口感染情況的影響。 方法  2006年11月-2006年12月，對(duì)28只新西蘭兔分為實(shí)驗(yàn)組和對(duì)照組，分別予細(xì)菌性膠原酶溶液及生理鹽水浸潤(rùn)創(chuàng)口并縫合。觀察創(chuàng)口感染及局部皮膚的炎性細(xì)胞浸潤(rùn)情況。 結(jié)果  實(shí)驗(yàn)組與對(duì)照組創(chuàng)口感染率差別無(wú)統(tǒng)計(jì)學(xué)意（P gt;0.05），炎性細(xì)胞差別無(wú)統(tǒng)計(jì)學(xué)意義（P gt;0.05）。 結(jié)論  細(xì)菌性膠原酶在創(chuàng)傷修復(fù)過(guò)程中不能直接降低感染率，對(duì)炎性細(xì)胞的遷移并無(wú)明顯的作用。 
【Abstract】 Objective  To assess the effects of bacterial collagenase on the wound infection. Methods  A total of 28 New Zealand rabbits have chosen from November to December 2006, and were divided into a laboratorial group and a control group. We sutured the wounds and soaked them by the bacterial collagenase liquid or by the physiologic saline solution. The infection and the inflammatory cells of the skin around the wound were observed. Results  The difference of the infection rates between the two groups was not statistically significant (P=0.62), nor the difference of inflammatory cells (P=0.84). Conclusions  Bacterial collagenase can not decrease the rate of infection directly, and had no obvious effect on the transferring of inflammatory cells.

引用本文： 邱里,何慶. 盲法研究細(xì)菌性膠原酶對(duì)創(chuàng)傷感染的影響. 華西醫(yī)學(xué), 2010, 25(10): 1815-1816. doi: 復(fù)制

1. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
2. Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
4. Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
5. 曲濱, 邵鐵濱, 楊心波, 等. 梭狀芽孢桿菌膠原酶治療深Ⅱ度燒傷的臨床觀察[J]. 黑龍江醫(yī)學(xué), 2003, 27(8): 590.
6. Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
7. Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
8. 程飚, 付小兵, 盛志勇, 等. 堿性成纖維細(xì)胞生長(zhǎng)因子對(duì)大鼠燙傷創(chuàng)面中基質(zhì)金屬蛋白及其抑制劑的影響[J]. 中華燒傷雜志, 2003, 19(6): 336-339.
9. 王世嶺, 李利根, 周亮, 等. 膠原酶對(duì)小面積深度燒傷創(chuàng)面清創(chuàng)效果分析[J]. 中國(guó)臨床藥理學(xué)雜志, 2000, 16(1): 18-21.
10. 李孝建, 劉錫麟, 霍麗貞. 愛(ài)療素軟膏對(duì)深度燒傷創(chuàng)面的療效觀察[J]. 廣東藥學(xué)報(bào), 2000, 16(1): 65-66.
11. 楊紅明, 柴家科, 郭振榮, 等. 創(chuàng)面用藥變革對(duì)深Ⅱ度燒傷創(chuàng)面愈合時(shí)間的影響[J]. 中國(guó)修復(fù)重建外科雜志, 2001, 15(3): 162-164.
12. 王配合, 齊順貞, 彭毅志. 愛(ài)療素軟膏對(duì)深Ⅱ度燒傷創(chuàng)面的療效觀察[J]. 華北國(guó)防醫(yī)藥, 2004, 16(1): 10-12.
  1. 1. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
  2. 2. Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
  3. 3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
  4. 4. Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
  5. 5. 曲濱, 邵鐵濱, 楊心波, 等. 梭狀芽孢桿菌膠原酶治療深Ⅱ度燒傷的臨床觀察[J]. 黑龍江醫(yī)學(xué), 2003, 27(8): 590.
  6. 6. Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
  7. 7. Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
  8. 8. 程飚, 付小兵, 盛志勇, 等. 堿性成纖維細(xì)胞生長(zhǎng)因子對(duì)大鼠燙傷創(chuàng)面中基質(zhì)金屬蛋白及其抑制劑的影響[J]. 中華燒傷雜志, 2003, 19(6): 336-339.
  9. 9. 王世嶺, 李利根, 周亮, 等. 膠原酶對(duì)小面積深度燒傷創(chuàng)面清創(chuàng)效果分析[J]. 中國(guó)臨床藥理學(xué)雜志, 2000, 16(1): 18-21.
  10. 10. 李孝建, 劉錫麟, 霍麗貞. 愛(ài)療素軟膏對(duì)深度燒傷創(chuàng)面的療效觀察[J]. 廣東藥學(xué)報(bào), 2000, 16(1): 65-66.
  11. 11. 楊紅明, 柴家科, 郭振榮, 等. 創(chuàng)面用藥變革對(duì)深Ⅱ度燒傷創(chuàng)面愈合時(shí)間的影響[J]. 中國(guó)修復(fù)重建外科雜志, 2001, 15(3): 162-164.
  12. 12. 王配合, 齊順貞, 彭毅志. 愛(ài)療素軟膏對(duì)深Ⅱ度燒傷創(chuàng)面的療效觀察[J]. 華北國(guó)防醫(yī)藥, 2004, 16(1): 10-12.