• 四川大學(xué)華西醫(yī)院甲狀腺乳腺外科（成都，610041）;

【摘要】乳腺癌在腫瘤發(fā)展早期就可遠(yuǎn)處播散，乳腺癌術(shù)后復(fù)發(fā)和轉(zhuǎn)移是影響預(yù)后的主要因素， 在外周血中發(fā)現(xiàn)腫瘤細(xì)胞即是重要證據(jù)， 因而提出了循環(huán)腫瘤細(xì)胞（circulating tumor cell， CTC）的概念。檢測(cè)乳腺癌CTC 有助于準(zhǔn)確的判斷預(yù)后，并為及時(shí)評(píng)判和監(jiān)測(cè)治療效果提供依據(jù)，有利于患者的個(gè)體化治療，具有重要的臨床意義。

引用本文： 龍泉伊,李宏江,林小燕. 循環(huán)腫瘤細(xì)胞在乳腺癌患者中的臨床意義. 華西醫(yī)學(xué), 2010, 25(10): 1927-1929. doi: 復(fù)制

1.
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4. Racila E, Euhus D, Weiss AJ, et al. Detection and characterization of carcinoma cells in the blood[J]. Proc Natl Acad Sci USA, 1998, 95(8): 4589-4594.
5. Gilbey AM, Burnett D, Coleman RE, et al. The detection of circulating cancer cells in blood[J]. J Clin Pathol, 2004, 57: 903-911.
6. 陳艷, 王熙才, 伍治平. 乳腺癌循環(huán)腫瘤細(xì)胞[J]. 國(guó)際腫瘤學(xué)雜志，2008, 35(2): 122-124.
7. Kirk SJ, Cooper GG, Hoper M, et al. The prognostic signifycancer of marrow micrometastases in women with early breast cancer[J]. Eur J Surg Oncol, 1990, 16: 481-485.
8. Osborne M, Rosen P. Detection and management of bone marrow micrometastases in breast cancer[J]. Oncology, 1994, 8: 25-36.
9. Sloane JP, Ormerod MG, Neville AM. Potential pathological application of immunocytochemical methods to the[VAC13] detec tion of micrometastases[J]. Cancer Res, 1980, 40(8): 3079-3082.
10. Irene G, Nicolas S, John N, et al. In vivo flow cytometry: A new method for enumerating circulating cancer cells[J]. Cancer Res, 2004, 64: 5044-5047.
11. Lee GS, Ryu KS, Rha JG, et al. Multiparametric flow cytometric analysis in a breast cancer cell line (MCF-7)[J]. J Obstet Gynaecol Res, 2002, 28(3): 141-148.
12. 孔雁, 姜達(dá). 循環(huán)腫瘤細(xì)胞的研究進(jìn)展[J]. 中國(guó)腫瘤, 2006, 15(3): 172-175.
13. 趙洪猛, 張斌, 湯小川, 等. 乳腺癌循環(huán)腫瘤細(xì)胞研究及其檢測(cè)進(jìn)展[J]. 中國(guó)腫瘤臨床, 2009, 36(15): 896-899.
14. Ring A, Smith IE, Dowsett M. Circulating tumor cells in breast cancer[J]. Lancet Oncol, 2004, 5(2): 79-88.
15. 李燕, 李大鵬, 馬德亮, 等. 乳腺癌患者循環(huán)腫瘤細(xì)胞的檢測(cè)及其臨床應(yīng)用[J]. 中國(guó)腫瘤外科雜志. 2010, 2(1):.
16. 鄭建, 李麗. 循環(huán)腫瘤細(xì)胞在乳腺癌中的研究現(xiàn)狀[J]. 現(xiàn)代腫瘤學(xué), 2009, 17, (6): 1158-1162.
17. Mikhitarian K, Martin RH, Ruppel MB, et al. Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study[J]. BMC Cancer, 2008, 8: 55.
18. Stathopoulou A, Gizi A, Perraki M, et al. Real- time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system[J]. Clin Cancer Res, 2003, 9(14): 5145.
19. Taubert H, Blumke K, Bilkenroth U, et al. Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases[J]. Gynecol Oncol, 2004, 92(1): 256.
20. 蔡清清, 黃慧強(qiáng), 林天歆, 等. 乳腺癌患者外周血中循環(huán)癌細(xì)胞的檢測(cè)及其臨床意義[J]. 癌癥, 2005, 24(7): 837-841.
21. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J]. N Engl J Med, 2004, 351(8): 781.
22. Wong NS, Kahn HJ, Zhang L, et al. Prognostic significance of circulating tumor cells enumerated after filtration enrichment in early and metastatic breast cancer patients [J]. Breast Cancer Res Treat, 2006, 99(1): 63-69.
23. Müller S, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity[J]. Clin Cancer Res, 2005, 11(10): 3678-3685.
24. Lobodasch K, Frohlich F, Rengsberger M, et al. Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: An increase in cell number at completion of therapy is a predictor of early relapse [J]. The Breast, 2007, 16: 211-218.
25. 齊曉偉, 姜軍. 乳腺癌循環(huán)腫瘤細(xì)胞臨床應(yīng)用研究進(jìn)展[J]. 中華腫瘤防治雜志, 2009, 16(5): 394-398.
26. 齊曉偉, 姜軍, 楊新華, 等. 乳腺癌循環(huán)腫瘤細(xì)胞與原發(fā)腫瘤臨床病理特征關(guān)系的初步研究[J]. 第三軍醫(yī)大學(xué)學(xué)報(bào), 2009. 31(9): 850-853.
  1. 1.
  2. 2. 寧連勝, 方志沂, 譯. 現(xiàn)代乳腺疾病治療學(xué)[M]. 2版. 北京: 人民衛(wèi)生出版社, 2007: 489.
  3. 3. Hüsemann Y, Geigl JB, Schubert F, et al. Systemic spread is an early step in breast cancer [J]. CancerCell, 2008, 13 (1): 58-68.
  4. 4. Racila E, Euhus D, Weiss AJ, et al. Detection and characterization of carcinoma cells in the blood[J]. Proc Natl Acad Sci USA, 1998, 95(8): 4589-4594.
  5. 5. Gilbey AM, Burnett D, Coleman RE, et al. The detection of circulating cancer cells in blood[J]. J Clin Pathol, 2004, 57: 903-911.
  6. 6. 陳艷, 王熙才, 伍治平. 乳腺癌循環(huán)腫瘤細(xì)胞[J]. 國(guó)際腫瘤學(xué)雜志，2008, 35(2): 122-124.
  7. 7. Kirk SJ, Cooper GG, Hoper M, et al. The prognostic signifycancer of marrow micrometastases in women with early breast cancer[J]. Eur J Surg Oncol, 1990, 16: 481-485.
  8. 8. Osborne M, Rosen P. Detection and management of bone marrow micrometastases in breast cancer[J]. Oncology, 1994, 8: 25-36.
  9. 9. Sloane JP, Ormerod MG, Neville AM. Potential pathological application of immunocytochemical methods to the[VAC13] detec tion of micrometastases[J]. Cancer Res, 1980, 40(8): 3079-3082.
  10. 10. Irene G, Nicolas S, John N, et al. In vivo flow cytometry: A new method for enumerating circulating cancer cells[J]. Cancer Res, 2004, 64: 5044-5047.
  11. 11. Lee GS, Ryu KS, Rha JG, et al. Multiparametric flow cytometric analysis in a breast cancer cell line (MCF-7)[J]. J Obstet Gynaecol Res, 2002, 28(3): 141-148.
  12. 12. 孔雁, 姜達(dá). 循環(huán)腫瘤細(xì)胞的研究進(jìn)展[J]. 中國(guó)腫瘤, 2006, 15(3): 172-175.
  13. 13. 趙洪猛, 張斌, 湯小川, 等. 乳腺癌循環(huán)腫瘤細(xì)胞研究及其檢測(cè)進(jìn)展[J]. 中國(guó)腫瘤臨床, 2009, 36(15): 896-899.
  14. 14. Ring A, Smith IE, Dowsett M. Circulating tumor cells in breast cancer[J]. Lancet Oncol, 2004, 5(2): 79-88.
  15. 15. 李燕, 李大鵬, 馬德亮, 等. 乳腺癌患者循環(huán)腫瘤細(xì)胞的檢測(cè)及其臨床應(yīng)用[J]. 中國(guó)腫瘤外科雜志. 2010, 2(1):.
  16. 16. 鄭建, 李麗. 循環(huán)腫瘤細(xì)胞在乳腺癌中的研究現(xiàn)狀[J]. 現(xiàn)代腫瘤學(xué), 2009, 17, (6): 1158-1162.
  17. 17. Mikhitarian K, Martin RH, Ruppel MB, et al. Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study[J]. BMC Cancer, 2008, 8: 55.
  18. 18. Stathopoulou A, Gizi A, Perraki M, et al. Real- time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system[J]. Clin Cancer Res, 2003, 9(14): 5145.
  19. 19. Taubert H, Blumke K, Bilkenroth U, et al. Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases[J]. Gynecol Oncol, 2004, 92(1): 256.
  20. 20. 蔡清清, 黃慧強(qiáng), 林天歆, 等. 乳腺癌患者外周血中循環(huán)癌細(xì)胞的檢測(cè)及其臨床意義[J]. 癌癥, 2005, 24(7): 837-841.
  21. 21. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J]. N Engl J Med, 2004, 351(8): 781.
  22. 22. Wong NS, Kahn HJ, Zhang L, et al. Prognostic significance of circulating tumor cells enumerated after filtration enrichment in early and metastatic breast cancer patients [J]. Breast Cancer Res Treat, 2006, 99(1): 63-69.
  23. 23. Müller S, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity[J]. Clin Cancer Res, 2005, 11(10): 3678-3685.
  24. 24. Lobodasch K, Frohlich F, Rengsberger M, et al. Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: An increase in cell number at completion of therapy is a predictor of early relapse [J]. The Breast, 2007, 16: 211-218.
  25. 25. 齊曉偉, 姜軍. 乳腺癌循環(huán)腫瘤細(xì)胞臨床應(yīng)用研究進(jìn)展[J]. 中華腫瘤防治雜志, 2009, 16(5): 394-398.
  26. 26. 齊曉偉, 姜軍, 楊新華, 等. 乳腺癌循環(huán)腫瘤細(xì)胞與原發(fā)腫瘤臨床病理特征關(guān)系的初步研究[J]. 第三軍醫(yī)大學(xué)學(xué)報(bào), 2009. 31(9): 850-853.