• 1.四川省婦幼保健院，四川成都 610031; 2.四川大學華西第二醫(yī)院，四川成都 610041;

目的：研究細胞間粘附分子-1(ICAM-1)和基質金屬蛋白酶9(MMP-9)在足月及早產分娩發(fā)動前后孕婦子宮下段肌層中的表達，探討ICAM-1和MMP-9在足月及早產分娩中的作用。方法：用免疫組織化學SP法檢測ICAM-1和MMP-9在足月及早產分娩發(fā)動前后各組孕婦子宮下段肌層中的表達。結果：足月及早產分娩發(fā)動組中ICAM-1在子宮下段肌層血管內皮細胞上的表達均顯著強于分娩未發(fā)動組。MMP-9在分娩發(fā)動子宮下段間質中的表達也均顯著強于分娩發(fā)動前。分娩發(fā)動后白細胞浸潤間質較分娩發(fā)動前明顯增加。結論：ICAM-1和MMP-9在足月及早產分娩發(fā)動中顯著增加，它們在分娩發(fā)動中具有重要作用。早產發(fā)生機制與足月分娩發(fā)動相似，類似于急性炎癥反應。

引用本文： 段瑞岐,曾蔚越,徐秀梅. ICAM-1和MMP-9在足月及早產分娩中的作用研究. 華西醫(yī)學, 2009, 24(2): 325-327. doi: 復制

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2. Thomson AJ，Telfer JF，Young A，et al.Leukocytes infiltrate the myometrium during human parturition：further evidence that labour is an inflammatory process[J].Hum Reprod，1999，14(1)：229..
3. Winkler M，Rath W.Changes in the cervical extracellular matrix during pregnancy and parturition[J].J Perinat Med，1999，27(1)：45..
4. Vainer B，Nielsen OH.Correlation between circulating soluble ICAM1 and predniso loneinducedamelio ration of ulcerative colitis[J].Scand J Gastroenterol，2003，38(3)：283..
5. Weiss A，Goldman S，Ben Shlomo I，et al.Mechanisms of matrixmetallo proteinase9 and matrix metallo proteinase2 inhibition by Nacetylcysteine in the human term decidua and fetalmembranes[J].Am J Obstet Gynecol，2003，189：1758-1763..
6. Stygar D，Wang H，Stjernholm VY，et al.Increased level of matrix metalloproteinase 2 and 9 in the ripening process of the human cervix[J].Biol Reprod，2002，67(3)：889-894..
7. Junquiera LCU，Zugaib M，Montes GS.Morphological and histochemical evidence for the occurrence of collagenolysis and for the role of the neutrophilic polymorphonuclear leukocytes during cervical dilatation[J].Am J Obstet Gynecol，1980，138：273-281..
8. Winkler M，DC Fischer，P Ruck，et al.Interleukin8 associated increase in the number of neutrophilic granulocytes in the cervical stroma as a basic mechanism of cervical dilatation duing parturition at term[J].Geburtsh Frauenheilk，1997，57：300..
9. Helen Fe，Huiling Ji，Jessie W，et al.Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term[J].Am J Obstet Gynecol，2005，192：753-760.
  1. 1. Winkler M，Ruck P，Horny HP.Expression of cell adhesion molecules by endothelium in the human lower uterine segment during parturition at term[J].Am J Obstet Gynecol，1998，178(3)：557-561..
  2. 2. Thomson AJ，Telfer JF，Young A，et al.Leukocytes infiltrate the myometrium during human parturition：further evidence that labour is an inflammatory process[J].Hum Reprod，1999，14(1)：229..
  3. 3. Winkler M，Rath W.Changes in the cervical extracellular matrix during pregnancy and parturition[J].J Perinat Med，1999，27(1)：45..
  4. 4. Vainer B，Nielsen OH.Correlation between circulating soluble ICAM1 and predniso loneinducedamelio ration of ulcerative colitis[J].Scand J Gastroenterol，2003，38(3)：283..
  5. 5. Weiss A，Goldman S，Ben Shlomo I，et al.Mechanisms of matrixmetallo proteinase9 and matrix metallo proteinase2 inhibition by Nacetylcysteine in the human term decidua and fetalmembranes[J].Am J Obstet Gynecol，2003，189：1758-1763..
  6. 6. Stygar D，Wang H，Stjernholm VY，et al.Increased level of matrix metalloproteinase 2 and 9 in the ripening process of the human cervix[J].Biol Reprod，2002，67(3)：889-894..
  7. 7. Junquiera LCU，Zugaib M，Montes GS.Morphological and histochemical evidence for the occurrence of collagenolysis and for the role of the neutrophilic polymorphonuclear leukocytes during cervical dilatation[J].Am J Obstet Gynecol，1980，138：273-281..
  8. 8. Winkler M，DC Fischer，P Ruck，et al.Interleukin8 associated increase in the number of neutrophilic granulocytes in the cervical stroma as a basic mechanism of cervical dilatation duing parturition at term[J].Geburtsh Frauenheilk，1997，57：300..
  9. 9. Helen Fe，Huiling Ji，Jessie W，et al.Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term[J].Am J Obstet Gynecol，2005，192：753-760.