• 1.川北醫(yī)學(xué)院附屬醫(yī)院腎內(nèi)科,四川南充 637000;2.四川省隆昌縣人民醫(yī)院內(nèi)分泌科,四川隆昌 642150;3.川北醫(yī)學(xué)院附屬醫(yī)院內(nèi)分泌科,四川南充 637000;

目的:觀察阿托伐他汀對(duì)抗糖尿病腎病患者腎氧化損傷作用。方法:56例糖尿病腎病患者隨即分為對(duì)照組和阿托伐他汀組。對(duì)照組給予降糖、降壓等治療,阿托伐他汀組則在對(duì)照組治療基礎(chǔ)上加用阿托伐他汀10 mg/d,療程共12周。檢測(cè)兩組患者治療前后FBG、BUN、Scr、尿微量白蛋白以及血脂、血清SOD和MDA水平。結(jié)果:12周后兩組患者FBG、BUN、Scr、尿微量白蛋白均較治療前下降;與治療前相比,阿托伐他汀組患者血脂水平較治療前明顯改善,同時(shí)患者血清SOD活性增,MDA含量下降,二者之間的差異具有顯著性意義。結(jié)論:阿托伐他汀除具有降血脂作用外,還可改善糖尿病腎病患者的氧化應(yīng)激狀態(tài)。

引用本文： 廖華偉,楊廷強(qiáng),嚴(yán)忠迅,任敏,劉曉惠,樊雷,涂莉榮. 阿托伐他汀對(duì)糖尿病腎病患者抗氧化應(yīng)激作用的臨床觀察. 華西醫(yī)學(xué), 2009, 24(3): 670-672. doi: 復(fù)制

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  3. 3. MARITIM AC,SANDERS RA,WAT KINS JB. Diabetes,oxidative stress,and antioxidants[J].Biochen Mol Toxicol,2003,17(1):24-38..
  4. 4. USNI H,SHIKATA K,MAT SUDA M,et al.HMGCoA reductase inhibitor ameliorates diabetic nephropat hy by its pleiotropic effects in rats[J].Nephrol Dial Transplant,2003,18(2):265272..
  5. 5. 于冬青,鄧華聰,劉金波,辛伐他汀對(duì)糖尿病大鼠腎臟氧化應(yīng)激的抑制作用[J].中國(guó)病理生理雜志,2006,22(4):824-825..
  6. 6. JONES SP,TESHIMA Y,AKAO M,et al.Simvastatin at tenuates oxidantinduced mitochondrial dysfunction in cardiac myocytes[J].Circ Res,2003,93(8):697-699..
  7. 7. 王雪艷,匡洪宇,糖尿病與糖尿病腎病患者氧化應(yīng)激狀態(tài)的分析[J].齊齊哈爾醫(yī)學(xué)院學(xué)報(bào),2008,29(6):694..
  8. 8. HENSLEY K,KOBINSON KA,GABBITA,et al.Reactive oxygen species,cell signaling,and cell injury[J].Free Radic Biol Med,2002,28(5):1456-1462..
  9. 9. GRAWEL S,WARDAS M,NIEDWOROK E,et al.Malondialdehyde(MDA)as a lipid peroxidation marker[J].Wiad Lek,2004,57(9-10):453-455..